Incidental Mutation 'IGL02253:Zyg11a'
ID 286503
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zyg11a
Ensembl Gene ENSMUSG00000034645
Gene Name zyg-11 family member A, cell cycle regulator
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.129) question?
Stock # IGL02253
Quality Score
Status
Chromosome 4
Chromosomal Location 108038935-108075245 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 108040892 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 685 (V685G)
Ref Sequence ENSEMBL: ENSMUSP00000038478 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043793] [ENSMUST00000052999] [ENSMUST00000106690] [ENSMUST00000116307] [ENSMUST00000116309] [ENSMUST00000223127] [ENSMUST00000130942] [ENSMUST00000126900] [ENSMUST00000125647]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000043793
AA Change: V685G

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000038478
Gene: ENSMUSG00000034645
AA Change: V685G

DomainStartEndE-ValueType
SCOP:d1jdha_ 218 700 2e-11 SMART
Blast:ARM 497 544 1e-5 BLAST
Blast:ARM 547 587 5e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000052999
SMART Domains Protein: ENSMUSP00000051268
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH_1 41 296 1.1e-60 PFAM
Pfam:ECH_2 46 225 5.1e-35 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000106690
AA Change: V687G

PolyPhen 2 Score 0.681 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000102301
Gene: ENSMUSG00000034645
AA Change: V687G

DomainStartEndE-ValueType
SCOP:d1jdha_ 139 621 1e-11 SMART
Blast:ARM 418 465 1e-5 BLAST
Blast:ARM 468 508 1e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000106691
SMART Domains Protein: ENSMUSP00000102302
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH_1 1 119 1.6e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000116307
SMART Domains Protein: ENSMUSP00000112009
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH 39 131 6.7e-17 PFAM
Pfam:ECH 124 257 5.3e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000116309
SMART Domains Protein: ENSMUSP00000112011
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH 39 288 3.2e-61 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133049
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127392
Predicted Effect probably null
Transcript: ENSMUST00000223127
AA Change: V687G

PolyPhen 2 Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect probably benign
Transcript: ENSMUST00000135718
SMART Domains Protein: ENSMUSP00000114371
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH_1 1 74 9.6e-16 PFAM
Pfam:ECH_2 2 74 1.1e-11 PFAM
Pfam:ECH_1 69 184 2.8e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000130942
SMART Domains Protein: ENSMUSP00000124746
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
Pfam:ECH 39 103 8.6e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000126900
Predicted Effect probably benign
Transcript: ENSMUST00000125647
SMART Domains Protein: ENSMUSP00000123913
Gene: ENSMUSG00000028601

DomainStartEndE-ValueType
low complexity region 45 62 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A G 7: 119,807,182 (GRCm39) E76G probably benign Het
Adamtsl2 A T 2: 26,988,709 (GRCm39) T587S possibly damaging Het
Adgre4 T A 17: 56,067,573 (GRCm39) M9K probably benign Het
Aff2 T A X: 68,874,397 (GRCm39) V447E probably benign Het
Arhgef10l G T 4: 140,271,595 (GRCm39) S425* probably null Het
Cabcoco1 T C 10: 68,272,107 (GRCm39) probably null Het
Calcr T A 6: 3,707,523 (GRCm39) H259L probably benign Het
Cdc42bpa T A 1: 179,859,161 (GRCm39) probably benign Het
Cntnap5b C T 1: 100,091,936 (GRCm39) H540Y possibly damaging Het
Cyp2a22 A T 7: 26,637,662 (GRCm39) probably benign Het
Ddx3x T C X: 13,151,207 (GRCm39) probably benign Het
Dnajc11 T A 4: 152,034,976 (GRCm39) Y28* probably null Het
Dock11 T C X: 35,304,781 (GRCm39) F1472S probably damaging Het
Dusp18 T C 11: 3,847,576 (GRCm39) *189Q probably null Het
Dzip3 A T 16: 48,765,287 (GRCm39) Y476N probably benign Het
Efr3b C T 12: 4,033,391 (GRCm39) V139I probably benign Het
Evc2 T A 5: 37,535,771 (GRCm39) probably benign Het
Fam151b A T 13: 92,614,435 (GRCm39) Y18N probably damaging Het
Gk5 T C 9: 96,019,824 (GRCm39) F120S probably damaging Het
Itprid2 A G 2: 79,490,788 (GRCm39) T969A probably damaging Het
Kcna3 T C 3: 106,944,727 (GRCm39) L330P probably damaging Het
Kctd20 A G 17: 29,180,460 (GRCm39) N7S probably benign Het
Kmt2b G T 7: 30,281,152 (GRCm39) R1276S probably damaging Het
Kmt2d C T 15: 98,756,056 (GRCm39) probably benign Het
L2hgdh G A 12: 69,752,534 (GRCm39) probably benign Het
Lifr T G 15: 7,220,085 (GRCm39) V905G probably damaging Het
Mcm3ap T A 10: 76,305,899 (GRCm39) V4E probably benign Het
Nrip3 A C 7: 109,360,951 (GRCm39) probably null Het
Nsun2 T G 13: 69,767,658 (GRCm39) V204G possibly damaging Het
Nup54 A G 5: 92,565,310 (GRCm39) probably null Het
Or5p69 T A 7: 107,967,261 (GRCm39) V188E possibly damaging Het
Or8c16 T A 9: 38,131,031 (GRCm39) M304K probably benign Het
Pdcl3 A G 1: 39,034,011 (GRCm39) D51G probably benign Het
Pdlim1 T C 19: 40,218,974 (GRCm39) E219G probably damaging Het
Pld4 A C 12: 112,733,141 (GRCm39) K239T probably damaging Het
Rgsl1 T C 1: 153,669,513 (GRCm39) Y291C probably damaging Het
Rnf213 C A 11: 119,331,476 (GRCm39) H2228Q probably benign Het
Rnf222 T A 11: 68,783,862 (GRCm39) I143N probably damaging Het
Sirt7 A G 11: 120,511,693 (GRCm39) I13T probably benign Het
Slfn10-ps A G 11: 82,919,890 (GRCm39) noncoding transcript Het
Slx4ip T C 2: 136,842,195 (GRCm39) probably null Het
Spata18 G T 5: 73,825,939 (GRCm39) S164I possibly damaging Het
Spmip2 C A 3: 79,356,741 (GRCm39) probably benign Het
Spmip2 C A 3: 79,356,742 (GRCm39) probably benign Het
Stk26 T C X: 49,975,565 (GRCm39) L212P probably damaging Het
Tmsb15a T C X: 134,620,451 (GRCm39) I56V probably benign Het
Tnrc6b T A 15: 80,760,742 (GRCm39) S150T probably damaging Het
Tubb3 T C 8: 124,147,559 (GRCm39) M164T probably benign Het
Zfp516 A G 18: 83,012,622 (GRCm39) D1125G probably benign Het
Other mutations in Zyg11a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Zyg11a APN 4 108,062,099 (GRCm39) missense probably damaging 0.99
IGL01517:Zyg11a APN 4 108,058,391 (GRCm39) missense probably null 1.00
IGL01619:Zyg11a APN 4 108,062,414 (GRCm39) missense probably damaging 1.00
R0090:Zyg11a UTSW 4 108,058,544 (GRCm39) splice site probably benign
R0225:Zyg11a UTSW 4 108,061,838 (GRCm39) missense probably damaging 1.00
R0610:Zyg11a UTSW 4 108,062,054 (GRCm39) missense probably damaging 1.00
R0827:Zyg11a UTSW 4 108,067,239 (GRCm39) splice site probably benign
R1568:Zyg11a UTSW 4 108,040,843 (GRCm39) critical splice donor site probably null
R1752:Zyg11a UTSW 4 108,062,479 (GRCm39) missense possibly damaging 0.81
R2051:Zyg11a UTSW 4 108,049,244 (GRCm39) splice site probably benign
R2358:Zyg11a UTSW 4 108,053,343 (GRCm39) missense possibly damaging 0.94
R3898:Zyg11a UTSW 4 108,067,391 (GRCm39) missense probably damaging 0.99
R4288:Zyg11a UTSW 4 108,041,666 (GRCm39) missense probably damaging 1.00
R4381:Zyg11a UTSW 4 108,058,517 (GRCm39) missense possibly damaging 0.58
R4709:Zyg11a UTSW 4 108,062,268 (GRCm39) missense probably benign 0.00
R4859:Zyg11a UTSW 4 108,067,387 (GRCm39) missense probably damaging 0.98
R5303:Zyg11a UTSW 4 108,041,629 (GRCm39) critical splice donor site probably null
R5349:Zyg11a UTSW 4 108,040,929 (GRCm39) missense probably damaging 1.00
R5363:Zyg11a UTSW 4 108,046,819 (GRCm39) missense probably damaging 1.00
R5517:Zyg11a UTSW 4 108,061,943 (GRCm39) missense possibly damaging 0.94
R6175:Zyg11a UTSW 4 108,046,878 (GRCm39) missense probably benign 0.01
R6254:Zyg11a UTSW 4 108,038,991 (GRCm39) missense probably damaging 1.00
R6678:Zyg11a UTSW 4 108,046,878 (GRCm39) missense probably benign 0.01
R7524:Zyg11a UTSW 4 108,049,271 (GRCm39) missense probably damaging 1.00
R7789:Zyg11a UTSW 4 108,040,845 (GRCm39) missense probably damaging 1.00
R8022:Zyg11a UTSW 4 108,046,765 (GRCm39) critical splice donor site probably null
R8437:Zyg11a UTSW 4 108,075,103 (GRCm39) missense probably damaging 1.00
R8986:Zyg11a UTSW 4 108,041,628 (GRCm39) critical splice donor site probably null
R9129:Zyg11a UTSW 4 108,039,009 (GRCm39) missense probably benign 0.00
R9383:Zyg11a UTSW 4 108,046,926 (GRCm39) missense probably damaging 1.00
R9457:Zyg11a UTSW 4 108,075,102 (GRCm39) missense probably damaging 1.00
R9489:Zyg11a UTSW 4 108,062,376 (GRCm39) missense probably damaging 0.96
R9511:Zyg11a UTSW 4 108,062,420 (GRCm39) missense probably damaging 1.00
X0061:Zyg11a UTSW 4 108,051,190 (GRCm39) missense probably damaging 1.00
Z1176:Zyg11a UTSW 4 108,058,479 (GRCm39) missense probably damaging 1.00
Z1177:Zyg11a UTSW 4 108,061,997 (GRCm39) missense possibly damaging 0.90
Posted On 2015-04-16