Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02253:Nrip3'

286520

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nrip3

Ensembl Gene

ENSMUSG00000034825

Gene Name

nuclear receptor interacting protein 3

Synonyms

A330103B05Rik, D7H11orf14, ICRFP703N2430Q5.2, ICRFP703B1614Q5.2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL02253

Quality Score

Status

Chromosome

Chromosomal Location

109357263-109380752 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to C at 109360951 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000044116 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033331] [ENSMUST00000041460] [ENSMUST00000207400]

AlphaFold

Q9JJR9

Predicted Effect

probably null
Transcript: ENSMUST00000033331

SMART Domains

Protein: ENSMUSP00000033331
Gene: ENSMUSG00000034825

Domain	Start	End	E-Value	Type
low complexity region	42	57	N/A	INTRINSIC
Pfam:Asp_protease	86	208	6e-16	PFAM
Pfam:Asp_protease_2	109	201	3.4e-11	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000041460

SMART Domains

Protein: ENSMUSP00000044116
Gene: ENSMUSG00000034825

Domain	Start	End	E-Value	Type
low complexity region	53	68	N/A	INTRINSIC
Pfam:Asp_protease	97	219	9.7e-16	PFAM
Pfam:Asp_protease_2	120	214	1e-10	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000207400

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca14	A	G	7: 119,807,182 (GRCm39)	E76G	probably benign	Het
Adamtsl2	A	T	2: 26,988,709 (GRCm39)	T587S	possibly damaging	Het
Adgre4	T	A	17: 56,067,573 (GRCm39)	M9K	probably benign	Het
Aff2	T	A	X: 68,874,397 (GRCm39)	V447E	probably benign	Het
Arhgef10l	G	T	4: 140,271,595 (GRCm39)	S425*	probably null	Het
Cabcoco1	T	C	10: 68,272,107 (GRCm39)		probably null	Het
Calcr	T	A	6: 3,707,523 (GRCm39)	H259L	probably benign	Het
Cdc42bpa	T	A	1: 179,859,161 (GRCm39)		probably benign	Het
Cntnap5b	C	T	1: 100,091,936 (GRCm39)	H540Y	possibly damaging	Het
Cyp2a22	A	T	7: 26,637,662 (GRCm39)		probably benign	Het
Ddx3x	T	C	X: 13,151,207 (GRCm39)		probably benign	Het
Dnajc11	T	A	4: 152,034,976 (GRCm39)	Y28*	probably null	Het
Dock11	T	C	X: 35,304,781 (GRCm39)	F1472S	probably damaging	Het
Dusp18	T	C	11: 3,847,576 (GRCm39)	*189Q	probably null	Het
Dzip3	A	T	16: 48,765,287 (GRCm39)	Y476N	probably benign	Het
Efr3b	C	T	12: 4,033,391 (GRCm39)	V139I	probably benign	Het
Evc2	T	A	5: 37,535,771 (GRCm39)		probably benign	Het
Fam151b	A	T	13: 92,614,435 (GRCm39)	Y18N	probably damaging	Het
Gk5	T	C	9: 96,019,824 (GRCm39)	F120S	probably damaging	Het
Itprid2	A	G	2: 79,490,788 (GRCm39)	T969A	probably damaging	Het
Kcna3	T	C	3: 106,944,727 (GRCm39)	L330P	probably damaging	Het
Kctd20	A	G	17: 29,180,460 (GRCm39)	N7S	probably benign	Het
Kmt2b	G	T	7: 30,281,152 (GRCm39)	R1276S	probably damaging	Het
Kmt2d	C	T	15: 98,756,056 (GRCm39)		probably benign	Het
L2hgdh	G	A	12: 69,752,534 (GRCm39)		probably benign	Het
Lifr	T	G	15: 7,220,085 (GRCm39)	V905G	probably damaging	Het
Mcm3ap	T	A	10: 76,305,899 (GRCm39)	V4E	probably benign	Het
Nsun2	T	G	13: 69,767,658 (GRCm39)	V204G	possibly damaging	Het
Nup54	A	G	5: 92,565,310 (GRCm39)		probably null	Het
Or5p69	T	A	7: 107,967,261 (GRCm39)	V188E	possibly damaging	Het
Or8c16	T	A	9: 38,131,031 (GRCm39)	M304K	probably benign	Het
Pdcl3	A	G	1: 39,034,011 (GRCm39)	D51G	probably benign	Het
Pdlim1	T	C	19: 40,218,974 (GRCm39)	E219G	probably damaging	Het
Pld4	A	C	12: 112,733,141 (GRCm39)	K239T	probably damaging	Het
Rgsl1	T	C	1: 153,669,513 (GRCm39)	Y291C	probably damaging	Het
Rnf213	C	A	11: 119,331,476 (GRCm39)	H2228Q	probably benign	Het
Rnf222	T	A	11: 68,783,862 (GRCm39)	I143N	probably damaging	Het
Sirt7	A	G	11: 120,511,693 (GRCm39)	I13T	probably benign	Het
Slfn10-ps	A	G	11: 82,919,890 (GRCm39)		noncoding transcript	Het
Slx4ip	T	C	2: 136,842,195 (GRCm39)		probably null	Het
Spata18	G	T	5: 73,825,939 (GRCm39)	S164I	possibly damaging	Het
Spmip2	C	A	3: 79,356,741 (GRCm39)		probably benign	Het
Spmip2	C	A	3: 79,356,742 (GRCm39)		probably benign	Het
Stk26	T	C	X: 49,975,565 (GRCm39)	L212P	probably damaging	Het
Tmsb15a	T	C	X: 134,620,451 (GRCm39)	I56V	probably benign	Het
Tnrc6b	T	A	15: 80,760,742 (GRCm39)	S150T	probably damaging	Het
Tubb3	T	C	8: 124,147,559 (GRCm39)	M164T	probably benign	Het
Zfp516	A	G	18: 83,012,622 (GRCm39)	D1125G	probably benign	Het
Zyg11a	A	C	4: 108,040,892 (GRCm39)	V685G	probably null	Het

Other mutations in Nrip3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01700:Nrip3	APN	7	109,361,074 (GRCm39)	missense	possibly damaging	0.95
PIT4696001:Nrip3	UTSW	7	109,364,714 (GRCm39)	nonsense	probably null
R0140:Nrip3	UTSW	7	109,361,022 (GRCm39)	unclassified	probably benign
R1179:Nrip3	UTSW	7	109,362,762 (GRCm39)	missense	probably damaging	1.00
R1828:Nrip3	UTSW	7	109,365,763 (GRCm39)	missense	probably benign	0.00
R5488:Nrip3	UTSW	7	109,361,045 (GRCm39)	missense	probably damaging	1.00
R5489:Nrip3	UTSW	7	109,361,045 (GRCm39)	missense	probably damaging	1.00
R6282:Nrip3	UTSW	7	109,362,686 (GRCm39)	splice site	probably null
R7134:Nrip3	UTSW	7	109,364,695 (GRCm39)	missense	probably damaging	0.99
R8414:Nrip3	UTSW	7	109,362,735 (GRCm39)	missense	possibly damaging	0.72
R9161:Nrip3	UTSW	7	109,365,777 (GRCm39)	missense	probably damaging	1.00
R9201:Nrip3	UTSW	7	109,360,906 (GRCm39)	missense	probably benign	0.05
R9641:Nrip3	UTSW	7	109,362,793 (GRCm39)	missense	probably damaging	1.00
Z1177:Nrip3	UTSW	7	109,365,782 (GRCm39)	missense	probably benign	0.34

Posted On

2015-04-16