Incidental Mutation 'IGL02257:Morn3'
| ID |
286628 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Morn3
|
| Ensembl Gene |
ENSMUSG00000029477 |
| Gene Name |
MORN repeat containing 3 |
| Synonyms |
4930438O03Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.118)
|
| Stock # |
IGL02257
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
5 |
| Chromosomal Location |
123173832-123185079 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 123175788 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Alanine
at position 200
(D200A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031437
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031437]
[ENSMUST00000045843]
[ENSMUST00000132775]
[ENSMUST00000145257]
|
| AlphaFold |
Q8C5T4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000031437
AA Change: D200A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000031437
Gene: ENSMUSG00000029477
AA Change: D200A
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
MORN
|
89 |
110 |
3.51e0 |
SMART |
|
MORN
|
112 |
133 |
3.09e-1 |
SMART |
|
MORN
|
135 |
156 |
1.15e-4 |
SMART |
|
MORN
|
158 |
179 |
2.57e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000045843
|
| SMART Domains |
Protein: ENSMUSP00000041714
Gene: ENSMUSG00000029477
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
MORN
|
89 |
110 |
3.51e0 |
SMART |
|
MORN
|
112 |
133 |
3.09e-1 |
SMART |
|
MORN
|
135 |
156 |
2.26e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129934
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132775
|
| SMART Domains |
Protein: ENSMUSP00000120199
Gene: ENSMUSG00000029477
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
MORN
|
89 |
110 |
3.51e0 |
SMART |
|
MORN
|
112 |
133 |
3.09e-1 |
SMART |
|
MORN
|
135 |
156 |
2.26e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000137490
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145257
|
| SMART Domains |
Protein: ENSMUSP00000122306
Gene: ENSMUSG00000029477
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197455
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aanat |
C |
T |
11: 116,486,535 (GRCm39) |
Q25* |
probably null |
Het |
| Adam8 |
A |
T |
7: 139,567,561 (GRCm39) |
V394D |
possibly damaging |
Het |
| Ahnak2 |
A |
G |
12: 112,748,905 (GRCm39) |
F314S |
possibly damaging |
Het |
| Arsg |
T |
C |
11: 109,412,473 (GRCm39) |
|
probably benign |
Het |
| Atp13a2 |
T |
G |
4: 140,733,400 (GRCm39) |
V958G |
probably benign |
Het |
| Ces5a |
T |
C |
8: 94,252,226 (GRCm39) |
D218G |
probably benign |
Het |
| Cntnap4 |
T |
A |
8: 113,343,126 (GRCm39) |
L63Q |
probably damaging |
Het |
| Cped1 |
A |
G |
6: 22,145,606 (GRCm39) |
T655A |
possibly damaging |
Het |
| Ddc |
A |
T |
11: 11,823,171 (GRCm39) |
L133* |
probably null |
Het |
| Fat4 |
C |
T |
3: 39,055,288 (GRCm39) |
A4169V |
probably benign |
Het |
| Gnpat |
T |
C |
8: 125,613,587 (GRCm39) |
|
probably benign |
Het |
| Gpd2 |
A |
G |
2: 57,254,536 (GRCm39) |
D678G |
probably benign |
Het |
| Hk1 |
T |
C |
10: 62,107,422 (GRCm39) |
D851G |
probably benign |
Het |
| Hsd11b2 |
G |
A |
8: 106,249,854 (GRCm39) |
V322I |
probably benign |
Het |
| Hsd17b3 |
G |
A |
13: 64,207,276 (GRCm39) |
T255M |
probably benign |
Het |
| Hsp90b1 |
T |
C |
10: 86,534,453 (GRCm39) |
S284G |
probably damaging |
Het |
| Med1 |
T |
A |
11: 98,071,096 (GRCm39) |
I69L |
probably damaging |
Het |
| Mmut |
C |
T |
17: 41,249,625 (GRCm39) |
T200I |
possibly damaging |
Het |
| Mtss1 |
A |
G |
15: 58,828,394 (GRCm39) |
V173A |
probably damaging |
Het |
| Myl6b |
T |
C |
10: 128,333,210 (GRCm39) |
|
probably benign |
Het |
| Nin |
A |
G |
12: 70,149,465 (GRCm39) |
V48A |
possibly damaging |
Het |
| Odr4 |
A |
T |
1: 150,262,155 (GRCm39) |
I95N |
probably damaging |
Het |
| Or10w1 |
G |
A |
19: 13,632,629 (GRCm39) |
V279I |
probably benign |
Het |
| Or2n1 |
G |
T |
17: 38,486,577 (GRCm39) |
V201L |
probably benign |
Het |
| Phlpp2 |
T |
A |
8: 110,646,731 (GRCm39) |
V529E |
possibly damaging |
Het |
| Pnlip |
G |
A |
19: 58,662,306 (GRCm39) |
V151I |
probably benign |
Het |
| Pus7 |
A |
C |
5: 23,967,459 (GRCm39) |
H247Q |
probably damaging |
Het |
| Setd6 |
T |
C |
8: 96,443,320 (GRCm39) |
Y188H |
probably damaging |
Het |
| Siglecg |
T |
C |
7: 43,061,328 (GRCm39) |
S444P |
probably benign |
Het |
| Sox9 |
C |
A |
11: 112,675,811 (GRCm39) |
H333Q |
possibly damaging |
Het |
| Specc1 |
T |
A |
11: 62,009,243 (GRCm39) |
I333N |
probably damaging |
Het |
| Tmprss11e |
G |
A |
5: 86,872,039 (GRCm39) |
T59I |
probably damaging |
Het |
| Vmn2r93 |
A |
C |
17: 18,545,770 (GRCm39) |
|
probably benign |
Het |
| Vrk2 |
A |
T |
11: 26,484,266 (GRCm39) |
V163D |
probably damaging |
Het |
|
| Other mutations in Morn3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01925:Morn3
|
APN |
5 |
123,184,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02516:Morn3
|
APN |
5 |
123,175,363 (GRCm39) |
nonsense |
probably null |
|
|
R0052:Morn3
|
UTSW |
5 |
123,184,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0052:Morn3
|
UTSW |
5 |
123,184,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0433:Morn3
|
UTSW |
5 |
123,177,396 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1854:Morn3
|
UTSW |
5 |
123,184,692 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4893:Morn3
|
UTSW |
5 |
123,175,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5854:Morn3
|
UTSW |
5 |
123,179,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5899:Morn3
|
UTSW |
5 |
123,179,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5983:Morn3
|
UTSW |
5 |
123,175,851 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6106:Morn3
|
UTSW |
5 |
123,184,823 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6766:Morn3
|
UTSW |
5 |
123,179,270 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7512:Morn3
|
UTSW |
5 |
123,175,343 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8722:Morn3
|
UTSW |
5 |
123,179,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8780:Morn3
|
UTSW |
5 |
123,175,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9782:Morn3
|
UTSW |
5 |
123,175,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Morn3
|
UTSW |
5 |
123,184,783 (GRCm39) |
frame shift |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation