Incidental Mutation 'IGL02263:Lrrc25'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc25
Ensembl Gene ENSMUSG00000049988
Gene Nameleucine rich repeat containing 25
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL02263
Quality Score
Chromosomal Location70616155-70621483 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 70617822 bp
Amino Acid Change Phenylalanine to Leucine at position 84 (F84L)
Ref Sequence ENSEMBL: ENSMUSP00000049686 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052437] [ENSMUST00000210609]
Predicted Effect probably benign
Transcript: ENSMUST00000052437
AA Change: F84L

PolyPhen 2 Score 0.271 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000049686
Gene: ENSMUSG00000049988
AA Change: F84L

signal peptide 1 25 N/A INTRINSIC
low complexity region 51 62 N/A INTRINSIC
Pfam:LRR_8 65 110 9.6e-8 PFAM
transmembrane domain 169 191 N/A INTRINSIC
low complexity region 192 199 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000210609
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff3 A G 1: 38,535,599 V100A probably damaging Het
Agmo T A 12: 37,357,697 N193K probably damaging Het
Dnah8 A G 17: 30,729,165 I1910V probably benign Het
Dsg2 T A 18: 20,590,020 S368T possibly damaging Het
Eif2ak4 A G 2: 118,461,778 T1270A probably benign Het
Ina T C 19: 47,015,487 S245P probably damaging Het
Katnb1 A G 8: 95,090,075 K96R probably damaging Het
Kcnj4 A G 15: 79,485,787 probably benign Het
Kcnn3 A G 3: 89,661,218 H601R possibly damaging Het
Ltb A G 17: 35,196,001 Y259C probably damaging Het
Macc1 T G 12: 119,446,017 N173K possibly damaging Het
Med17 A T 9: 15,267,476 N466K probably damaging Het
Ncoa2 A T 1: 13,174,763 N570K probably damaging Het
Olfr1051 T A 2: 86,276,202 Y95F probably benign Het
Olfr1134 A T 2: 87,656,199 C241S probably damaging Het
Olfr629 A T 7: 103,741,055 F62I probably damaging Het
Plb1 T C 5: 32,321,348 probably benign Het
Ptprk G A 10: 28,075,114 V12I unknown Het
Rabggta G A 14: 55,718,961 probably benign Het
Slc41a2 A G 10: 83,313,500 V193A possibly damaging Het
Thbs1 A G 2: 118,119,880 N665D probably benign Het
Tm9sf1 T C 14: 55,642,935 T2A possibly damaging Het
Traf7 C A 17: 24,513,046 C193F possibly damaging Het
Vmn1r91 A G 7: 20,101,843 D229G probably benign Het
Vmn2r7 A C 3: 64,691,447 V654G probably damaging Het
Other mutations in Lrrc25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01870:Lrrc25 APN 8 70617787 missense possibly damaging 0.83
IGL02354:Lrrc25 APN 8 70617827 missense probably benign
IGL02361:Lrrc25 APN 8 70617827 missense probably benign
R0320:Lrrc25 UTSW 8 70618246 missense probably benign 0.00
R1863:Lrrc25 UTSW 8 70617946 missense possibly damaging 0.83
R4816:Lrrc25 UTSW 8 70618076 missense probably benign
R6696:Lrrc25 UTSW 8 70618365 critical splice donor site probably null
R7169:Lrrc25 UTSW 8 70617787 missense probably benign 0.27
R7394:Lrrc25 UTSW 8 70618180 missense possibly damaging 0.60
Posted On2015-04-16