Incidental Mutation 'IGL02263:Lrrc25'
ID |
286824 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Lrrc25
|
Ensembl Gene |
ENSMUSG00000049988 |
Gene Name |
leucine rich repeat containing 25 |
Synonyms |
Mapa |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.082)
|
Stock # |
IGL02263
|
Quality Score |
|
Status
|
|
Chromosome |
8 |
Chromosomal Location |
71068810-71073501 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to A
at 71070472 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Leucine
at position 84
(F84L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000049686
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000052437]
[ENSMUST00000210609]
|
AlphaFold |
Q8K1T1 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000052437
AA Change: F84L
PolyPhen 2
Score 0.271 (Sensitivity: 0.91; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000049686 Gene: ENSMUSG00000049988 AA Change: F84L
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
low complexity region
|
51 |
62 |
N/A |
INTRINSIC |
Pfam:LRR_8
|
65 |
110 |
9.6e-8 |
PFAM |
transmembrane domain
|
169 |
191 |
N/A |
INTRINSIC |
low complexity region
|
192 |
199 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000210609
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 25 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aff3 |
A |
G |
1: 38,574,680 (GRCm39) |
V100A |
probably damaging |
Het |
Agmo |
T |
A |
12: 37,407,696 (GRCm39) |
N193K |
probably damaging |
Het |
Dnah8 |
A |
G |
17: 30,948,139 (GRCm39) |
I1910V |
probably benign |
Het |
Dsg2 |
T |
A |
18: 20,723,077 (GRCm39) |
S368T |
possibly damaging |
Het |
Eif2ak4 |
A |
G |
2: 118,292,259 (GRCm39) |
T1270A |
probably benign |
Het |
Ina |
T |
C |
19: 47,003,926 (GRCm39) |
S245P |
probably damaging |
Het |
Katnb1 |
A |
G |
8: 95,816,703 (GRCm39) |
K96R |
probably damaging |
Het |
Kcnj4 |
A |
G |
15: 79,369,988 (GRCm39) |
|
probably benign |
Het |
Kcnn3 |
A |
G |
3: 89,568,525 (GRCm39) |
H601R |
possibly damaging |
Het |
Ltb |
A |
G |
17: 35,414,977 (GRCm39) |
Y259C |
probably damaging |
Het |
Macc1 |
T |
G |
12: 119,409,752 (GRCm39) |
N173K |
possibly damaging |
Het |
Med17 |
A |
T |
9: 15,178,772 (GRCm39) |
N466K |
probably damaging |
Het |
Ncoa2 |
A |
T |
1: 13,244,987 (GRCm39) |
N570K |
probably damaging |
Het |
Or52ae9 |
A |
T |
7: 103,390,262 (GRCm39) |
F62I |
probably damaging |
Het |
Or5w1 |
A |
T |
2: 87,486,543 (GRCm39) |
C241S |
probably damaging |
Het |
Or8k20 |
T |
A |
2: 86,106,546 (GRCm39) |
Y95F |
probably benign |
Het |
Plb1 |
T |
C |
5: 32,478,692 (GRCm39) |
|
probably benign |
Het |
Ptprk |
G |
A |
10: 27,951,110 (GRCm39) |
V12I |
unknown |
Het |
Rabggta |
G |
A |
14: 55,956,418 (GRCm39) |
|
probably benign |
Het |
Slc41a2 |
A |
G |
10: 83,149,364 (GRCm39) |
V193A |
possibly damaging |
Het |
Thbs1 |
A |
G |
2: 117,950,361 (GRCm39) |
N665D |
probably benign |
Het |
Tm9sf1 |
T |
C |
14: 55,880,392 (GRCm39) |
T2A |
possibly damaging |
Het |
Traf7 |
C |
A |
17: 24,732,020 (GRCm39) |
C193F |
possibly damaging |
Het |
Vmn1r91 |
A |
G |
7: 19,835,768 (GRCm39) |
D229G |
probably benign |
Het |
Vmn2r7 |
A |
C |
3: 64,598,868 (GRCm39) |
V654G |
probably damaging |
Het |
|
Other mutations in Lrrc25 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01870:Lrrc25
|
APN |
8 |
71,070,437 (GRCm39) |
missense |
possibly damaging |
0.83 |
IGL02354:Lrrc25
|
APN |
8 |
71,070,477 (GRCm39) |
missense |
probably benign |
|
IGL02361:Lrrc25
|
APN |
8 |
71,070,477 (GRCm39) |
missense |
probably benign |
|
R0320:Lrrc25
|
UTSW |
8 |
71,070,896 (GRCm39) |
missense |
probably benign |
0.00 |
R1863:Lrrc25
|
UTSW |
8 |
71,070,596 (GRCm39) |
missense |
possibly damaging |
0.83 |
R4816:Lrrc25
|
UTSW |
8 |
71,070,726 (GRCm39) |
missense |
probably benign |
|
R6696:Lrrc25
|
UTSW |
8 |
71,071,015 (GRCm39) |
critical splice donor site |
probably null |
|
R7169:Lrrc25
|
UTSW |
8 |
71,070,437 (GRCm39) |
missense |
probably benign |
0.27 |
R7394:Lrrc25
|
UTSW |
8 |
71,070,830 (GRCm39) |
missense |
possibly damaging |
0.60 |
R7958:Lrrc25
|
UTSW |
8 |
71,070,497 (GRCm39) |
missense |
possibly damaging |
0.66 |
R8681:Lrrc25
|
UTSW |
8 |
71,070,314 (GRCm39) |
missense |
possibly damaging |
0.46 |
R8708:Lrrc25
|
UTSW |
8 |
71,070,459 (GRCm39) |
missense |
probably damaging |
0.97 |
R8778:Lrrc25
|
UTSW |
8 |
71,070,242 (GRCm39) |
missense |
possibly damaging |
0.66 |
R9281:Lrrc25
|
UTSW |
8 |
71,073,246 (GRCm39) |
missense |
probably benign |
0.04 |
|
Posted On |
2015-04-16 |