Incidental Mutation 'IGL02263:Lrrc25'
ID 286824
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc25
Ensembl Gene ENSMUSG00000049988
Gene Name leucine rich repeat containing 25
Synonyms Mapa
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # IGL02263
Quality Score
Status
Chromosome 8
Chromosomal Location 71068810-71073501 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 71070472 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 84 (F84L)
Ref Sequence ENSEMBL: ENSMUSP00000049686 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052437] [ENSMUST00000210609]
AlphaFold Q8K1T1
Predicted Effect probably benign
Transcript: ENSMUST00000052437
AA Change: F84L

PolyPhen 2 Score 0.271 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000049686
Gene: ENSMUSG00000049988
AA Change: F84L

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
low complexity region 51 62 N/A INTRINSIC
Pfam:LRR_8 65 110 9.6e-8 PFAM
transmembrane domain 169 191 N/A INTRINSIC
low complexity region 192 199 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000210609
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff3 A G 1: 38,574,680 (GRCm39) V100A probably damaging Het
Agmo T A 12: 37,407,696 (GRCm39) N193K probably damaging Het
Dnah8 A G 17: 30,948,139 (GRCm39) I1910V probably benign Het
Dsg2 T A 18: 20,723,077 (GRCm39) S368T possibly damaging Het
Eif2ak4 A G 2: 118,292,259 (GRCm39) T1270A probably benign Het
Ina T C 19: 47,003,926 (GRCm39) S245P probably damaging Het
Katnb1 A G 8: 95,816,703 (GRCm39) K96R probably damaging Het
Kcnj4 A G 15: 79,369,988 (GRCm39) probably benign Het
Kcnn3 A G 3: 89,568,525 (GRCm39) H601R possibly damaging Het
Ltb A G 17: 35,414,977 (GRCm39) Y259C probably damaging Het
Macc1 T G 12: 119,409,752 (GRCm39) N173K possibly damaging Het
Med17 A T 9: 15,178,772 (GRCm39) N466K probably damaging Het
Ncoa2 A T 1: 13,244,987 (GRCm39) N570K probably damaging Het
Or52ae9 A T 7: 103,390,262 (GRCm39) F62I probably damaging Het
Or5w1 A T 2: 87,486,543 (GRCm39) C241S probably damaging Het
Or8k20 T A 2: 86,106,546 (GRCm39) Y95F probably benign Het
Plb1 T C 5: 32,478,692 (GRCm39) probably benign Het
Ptprk G A 10: 27,951,110 (GRCm39) V12I unknown Het
Rabggta G A 14: 55,956,418 (GRCm39) probably benign Het
Slc41a2 A G 10: 83,149,364 (GRCm39) V193A possibly damaging Het
Thbs1 A G 2: 117,950,361 (GRCm39) N665D probably benign Het
Tm9sf1 T C 14: 55,880,392 (GRCm39) T2A possibly damaging Het
Traf7 C A 17: 24,732,020 (GRCm39) C193F possibly damaging Het
Vmn1r91 A G 7: 19,835,768 (GRCm39) D229G probably benign Het
Vmn2r7 A C 3: 64,598,868 (GRCm39) V654G probably damaging Het
Other mutations in Lrrc25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01870:Lrrc25 APN 8 71,070,437 (GRCm39) missense possibly damaging 0.83
IGL02354:Lrrc25 APN 8 71,070,477 (GRCm39) missense probably benign
IGL02361:Lrrc25 APN 8 71,070,477 (GRCm39) missense probably benign
R0320:Lrrc25 UTSW 8 71,070,896 (GRCm39) missense probably benign 0.00
R1863:Lrrc25 UTSW 8 71,070,596 (GRCm39) missense possibly damaging 0.83
R4816:Lrrc25 UTSW 8 71,070,726 (GRCm39) missense probably benign
R6696:Lrrc25 UTSW 8 71,071,015 (GRCm39) critical splice donor site probably null
R7169:Lrrc25 UTSW 8 71,070,437 (GRCm39) missense probably benign 0.27
R7394:Lrrc25 UTSW 8 71,070,830 (GRCm39) missense possibly damaging 0.60
R7958:Lrrc25 UTSW 8 71,070,497 (GRCm39) missense possibly damaging 0.66
R8681:Lrrc25 UTSW 8 71,070,314 (GRCm39) missense possibly damaging 0.46
R8708:Lrrc25 UTSW 8 71,070,459 (GRCm39) missense probably damaging 0.97
R8778:Lrrc25 UTSW 8 71,070,242 (GRCm39) missense possibly damaging 0.66
R9281:Lrrc25 UTSW 8 71,073,246 (GRCm39) missense probably benign 0.04
Posted On 2015-04-16