Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02264:Iglc2'

286851

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Iglc2

Ensembl Gene

ENSMUSG00000076937

Gene Name

immunoglobulin lambda constant 2

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

IGL02264

Quality Score

Status

Chromosome

Chromosomal Location

19017286-19017602 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 19017397 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 69 (S69R)

Ref Sequence

ENSEMBL: ENSMUSP00000143153 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103749] [ENSMUST00000198182]

AlphaFold

P01844

Predicted Effect

probably damaging
Transcript: ENSMUST00000103749
AA Change: S68R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000100464
Gene: ENSMUSG00000076937
AA Change: S68R

Domain	Start	End	E-Value	Type
IGc1	22	95	4.47e-33	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000197046

Predicted Effect

probably benign
Transcript: ENSMUST00000197969

Predicted Effect

probably damaging
Transcript: ENSMUST00000198182
AA Change: S69R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000143153
Gene: ENSMUSG00000076937
AA Change: S69R

Domain	Start	End	E-Value	Type
IGc1	23	96	1.8e-35	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000198313

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921504E06Rik	A	G	2: 19,547,180 (GRCm39)		probably null	Het
Abhd17b	T	C	19: 21,655,796 (GRCm39)	L26P	probably damaging	Het
Abtb1	A	G	6: 88,813,517 (GRCm39)	V407A	probably benign	Het
Adamts17	C	A	7: 66,697,207 (GRCm39)		probably null	Het
Arhgap21	G	T	2: 20,864,850 (GRCm39)		probably null	Het
Brwd1	T	C	16: 95,820,656 (GRCm39)	D1290G	probably damaging	Het
Btbd6	A	G	12: 112,940,589 (GRCm39)	T49A	probably damaging	Het
Carmil1	C	T	13: 24,259,699 (GRCm39)	V702I	possibly damaging	Het
Cts8	T	A	13: 61,398,772 (GRCm39)	I245F	probably damaging	Het
Dclre1a	T	A	19: 56,532,725 (GRCm39)	N623I	possibly damaging	Het
Dnah9	A	T	11: 65,971,314 (GRCm39)		probably benign	Het
Emc1	T	C	4: 139,102,775 (GRCm39)	F978S	probably damaging	Het
Fam185a	G	A	5: 21,685,392 (GRCm39)	V363I	possibly damaging	Het
Ints5	T	C	19: 8,873,076 (GRCm39)	V345A	probably benign	Het
Kif21b	T	A	1: 136,087,495 (GRCm39)	L937Q	probably damaging	Het
Lrba	A	G	3: 86,687,569 (GRCm39)	R2825G	probably damaging	Het
Map1a	A	G	2: 121,137,794 (GRCm39)	E2870G	probably damaging	Het
Or4c125	G	T	2: 89,170,028 (GRCm39)	T206K	probably benign	Het
Or4k41	A	G	2: 111,280,207 (GRCm39)	T241A	probably benign	Het
Or5aq7	C	T	2: 86,937,785 (GRCm39)		probably benign	Het
Or8b48	C	T	9: 38,492,809 (GRCm39)	P79S	probably damaging	Het
Pcsk1	C	A	13: 75,254,078 (GRCm39)	T210K	probably damaging	Het
Phaf1	C	T	8: 105,961,178 (GRCm39)	A71V	possibly damaging	Het
Slco5a1	A	G	1: 12,942,219 (GRCm39)	V809A	probably benign	Het
Synm	T	C	7: 67,384,144 (GRCm39)	T1173A	probably damaging	Het
Tbc1d9b	T	C	11: 50,040,584 (GRCm39)	I367T	probably damaging	Het
Tmem169	T	A	1: 72,340,114 (GRCm39)	Y181*	probably null	Het
Trp73	G	T	4: 154,148,885 (GRCm39)	F289L	probably null	Het
Ttll9	A	G	2: 152,842,055 (GRCm39)	Y303C	probably damaging	Het
Ubr4	G	T	4: 139,182,939 (GRCm39)	E3577*	probably null	Het
Zbtb3	T	G	19: 8,780,729 (GRCm39)	V114G	probably damaging	Het

Other mutations in Iglc2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02125:Iglc2	APN	16	19,017,462 (GRCm39)	missense	probably benign	0.03
IGL02229:Iglc2	APN	16	19,017,483 (GRCm39)	missense	probably benign	0.04
R0674:Iglc2	UTSW	16	19,017,591 (GRCm39)	missense	probably benign	0.29
R5709:Iglc2	UTSW	16	19,017,384 (GRCm39)	missense	probably benign	0.39
R7394:Iglc2	UTSW	16	19,013,886 (GRCm39)	nonsense	probably null
R8252:Iglc2	UTSW	16	19,017,520 (GRCm39)	nonsense	probably null
R9004:Iglc2	UTSW	16	19,017,425 (GRCm39)	missense	probably benign	0.17
R9121:Iglc2	UTSW	16	19,017,294 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16