Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02266:Trappc11'

286901

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trappc11

Ensembl Gene

ENSMUSG00000038102

Gene Name

trafficking protein particle complex 11

Synonyms

D030016E14Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02266

Quality Score

Status

Chromosome

Chromosomal Location

47943163-47986505 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 47958766 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Glycine at position 42 (C42G)

Ref Sequence

ENSEMBL: ENSMUSP00000113779 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039061] [ENSMUST00000120987]

AlphaFold

B2RXC1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000039061
AA Change: C698G

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000047562
Gene: ENSMUSG00000038102
AA Change: C698G

Domain	Start	End	E-Value	Type
Pfam:Foie-gras_1	263	522	3e-78	PFAM
Pfam:Gryzun	978	1114	3.9e-10	PFAM
Pfam:Gryzun-like	1036	1095	2.4e-28	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000120987
AA Change: C42G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000113779
Gene: ENSMUSG00000038102
AA Change: C42G

Domain	Start	End	E-Value	Type
Pfam:Gryzun	1	155	4e-25	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123958

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125065

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	G	A	1: 71,307,360 (GRCm39)	Q1974*	probably null	Het
Actl11	G	T	9: 107,808,382 (GRCm39)	V902L	possibly damaging	Het
Adam11	T	C	11: 102,663,493 (GRCm39)	V274A	probably damaging	Het
Akr1b8	A	G	6: 34,331,208 (GRCm39)	I15V	probably benign	Het
Chrm3	T	A	13: 9,927,314 (GRCm39)	Q574L	probably damaging	Het
Ciao3	T	A	17: 25,999,300 (GRCm39)	I238N	possibly damaging	Het
Crk	C	A	11: 75,570,415 (GRCm39)	R16S	probably damaging	Het
Ep400	T	C	5: 110,843,163 (GRCm39)		probably benign	Het
Eya1	T	C	1: 14,254,725 (GRCm39)	N369S	possibly damaging	Het
Fam220a	T	C	5: 143,549,326 (GRCm39)	V246A	possibly damaging	Het
Fastkd5	A	T	2: 130,457,481 (GRCm39)	F370I	probably damaging	Het
Fhdc1	G	A	3: 84,352,042 (GRCm39)	A1061V	possibly damaging	Het
Gpr75	A	C	11: 30,841,977 (GRCm39)	Q294P	probably benign	Het
Hspg2	T	C	4: 137,237,888 (GRCm39)	F204L	probably damaging	Het
Lrrc8c	A	C	5: 105,756,114 (GRCm39)	I630L	probably benign	Het
Nlrc4	T	C	17: 74,753,162 (GRCm39)	D407G	possibly damaging	Het
Or4f61	G	A	2: 111,922,588 (GRCm39)	L153F	probably benign	Het
Or8k22	T	A	2: 86,163,323 (GRCm39)	I126F	probably damaging	Het
Pank1	A	C	19: 34,791,086 (GRCm39)		probably benign	Het
Pde3b	A	G	7: 114,126,201 (GRCm39)	T812A	probably damaging	Het
Phtf2	T	G	5: 21,010,797 (GRCm39)	K63Q	probably damaging	Het
Pkhd1l1	A	T	15: 44,437,010 (GRCm39)	H3456L	probably damaging	Het
Plcd1	A	G	9: 118,903,855 (GRCm39)		probably benign	Het
Ppip5k2	C	T	1: 97,661,697 (GRCm39)	V734I	possibly damaging	Het
Ppp2r2d	A	G	7: 138,470,166 (GRCm39)	N38S	probably damaging	Het
Rnpepl1	T	A	1: 92,844,611 (GRCm39)	W368R	probably damaging	Het
Sidt1	T	C	16: 44,075,348 (GRCm39)	D670G	possibly damaging	Het
Slc12a2	T	A	18: 58,045,092 (GRCm39)		probably benign	Het
Tekt5	A	T	16: 10,196,906 (GRCm39)	I315N	probably benign	Het
Trerf1	C	T	17: 47,626,331 (GRCm39)		noncoding transcript	Het
Ubqlnl	C	A	7: 103,798,754 (GRCm39)	E248*	probably null	Het
Ulk4	G	T	9: 120,910,766 (GRCm39)	T1086K	probably benign	Het
Unc45a	A	T	7: 79,978,234 (GRCm39)	D680E	probably damaging	Het
Vmn2r107	T	C	17: 20,577,039 (GRCm39)	Y346H	probably damaging	Het
Vmn2r73	A	G	7: 85,525,007 (GRCm39)	I47T	possibly damaging	Het
Zbtb9	T	C	17: 27,193,129 (GRCm39)	V178A	probably benign	Het
Zc3hav1	A	T	6: 38,309,103 (GRCm39)	M573K	probably benign	Het
Zfp608	T	C	18: 55,030,653 (GRCm39)	T1096A	probably benign	Het

Other mutations in Trappc11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Trappc11	APN	8	47,956,337 (GRCm39)	unclassified	probably benign
IGL01300:Trappc11	APN	8	47,954,903 (GRCm39)	missense	probably benign
IGL01312:Trappc11	APN	8	47,958,712 (GRCm39)	missense	possibly damaging	0.95
IGL01344:Trappc11	APN	8	47,972,739 (GRCm39)	missense	probably damaging	1.00
IGL01518:Trappc11	APN	8	47,954,904 (GRCm39)	splice site	probably null
IGL01747:Trappc11	APN	8	47,972,656 (GRCm39)	missense	probably benign	0.41
IGL01781:Trappc11	APN	8	47,967,163 (GRCm39)	missense	possibly damaging	0.95
IGL01908:Trappc11	APN	8	47,957,029 (GRCm39)	missense	probably damaging	1.00
IGL01956:Trappc11	APN	8	47,981,036 (GRCm39)	missense	possibly damaging	0.86
IGL02377:Trappc11	APN	8	47,983,685 (GRCm39)	critical splice donor site	probably null
IGL02530:Trappc11	APN	8	47,960,617 (GRCm39)	missense	probably damaging	1.00
IGL02676:Trappc11	APN	8	47,946,448 (GRCm39)	splice site	probably benign
IGL03030:Trappc11	APN	8	47,966,964 (GRCm39)	missense	probably damaging	0.98
IGL03393:Trappc11	APN	8	47,963,912 (GRCm39)	missense	possibly damaging	0.95
bantu	UTSW	8	47,951,701 (GRCm39)	missense	probably benign	0.44
bunyoro	UTSW	8	47,965,320 (GRCm39)	splice site	probably null
nyoro	UTSW	8	47,980,014 (GRCm39)	missense	possibly damaging	0.73
serval	UTSW	8	47,957,000 (GRCm39)	missense	probably damaging	1.00
R0009:Trappc11	UTSW	8	47,956,355 (GRCm39)	missense	possibly damaging	0.70
R0009:Trappc11	UTSW	8	47,956,355 (GRCm39)	missense	possibly damaging	0.70
R0043:Trappc11	UTSW	8	47,958,610 (GRCm39)	splice site	probably benign
R0180:Trappc11	UTSW	8	47,981,009 (GRCm39)	missense	possibly damaging	0.86
R0529:Trappc11	UTSW	8	47,980,014 (GRCm39)	missense	possibly damaging	0.73
R0538:Trappc11	UTSW	8	47,956,447 (GRCm39)	missense	probably benign	0.01
R0740:Trappc11	UTSW	8	47,977,623 (GRCm39)	missense	probably damaging	0.99
R1352:Trappc11	UTSW	8	47,978,081 (GRCm39)	missense	possibly damaging	0.90
R1469:Trappc11	UTSW	8	47,957,000 (GRCm39)	missense	probably damaging	1.00
R1469:Trappc11	UTSW	8	47,957,000 (GRCm39)	missense	probably damaging	1.00
R1502:Trappc11	UTSW	8	47,983,862 (GRCm39)	missense	possibly damaging	0.94
R1589:Trappc11	UTSW	8	47,954,715 (GRCm39)	missense	probably damaging	1.00
R1741:Trappc11	UTSW	8	47,982,362 (GRCm39)	critical splice donor site	probably null
R2292:Trappc11	UTSW	8	47,958,771 (GRCm39)	missense	probably damaging	1.00
R2303:Trappc11	UTSW	8	47,956,451 (GRCm39)	missense	probably damaging	0.99
R2931:Trappc11	UTSW	8	47,956,977 (GRCm39)	missense	probably damaging	0.99
R3522:Trappc11	UTSW	8	47,951,708 (GRCm39)	missense	possibly damaging	0.93
R3714:Trappc11	UTSW	8	47,958,351 (GRCm39)	intron	probably benign
R3739:Trappc11	UTSW	8	47,967,138 (GRCm39)	missense	probably damaging	0.98
R4165:Trappc11	UTSW	8	47,978,003 (GRCm39)	splice site	probably benign
R4581:Trappc11	UTSW	8	47,946,380 (GRCm39)	missense	probably damaging	0.97
R4598:Trappc11	UTSW	8	47,966,801 (GRCm39)	missense	probably damaging	0.98
R4939:Trappc11	UTSW	8	47,972,700 (GRCm39)	missense	probably damaging	1.00
R4990:Trappc11	UTSW	8	47,943,930 (GRCm39)	missense	probably benign	0.41
R4994:Trappc11	UTSW	8	47,975,476 (GRCm39)	nonsense	probably null
R5091:Trappc11	UTSW	8	47,965,639 (GRCm39)	missense	probably benign	0.00
R5123:Trappc11	UTSW	8	47,966,437 (GRCm39)	missense	probably damaging	0.99
R5176:Trappc11	UTSW	8	47,963,998 (GRCm39)	missense	possibly damaging	0.79
R5279:Trappc11	UTSW	8	47,958,339 (GRCm39)	intron	probably benign
R5293:Trappc11	UTSW	8	47,946,377 (GRCm39)	missense	possibly damaging	0.83
R5294:Trappc11	UTSW	8	47,983,766 (GRCm39)	missense	possibly damaging	0.88
R5661:Trappc11	UTSW	8	47,965,642 (GRCm39)	missense	probably damaging	0.99
R5838:Trappc11	UTSW	8	47,965,594 (GRCm39)	critical splice donor site	probably null
R5889:Trappc11	UTSW	8	47,972,613 (GRCm39)	missense	probably benign	0.40
R5952:Trappc11	UTSW	8	47,949,952 (GRCm39)	critical splice donor site	probably null
R5959:Trappc11	UTSW	8	47,954,593 (GRCm39)	missense	probably damaging	0.97
R6239:Trappc11	UTSW	8	47,982,529 (GRCm39)	missense	possibly damaging	0.73
R6322:Trappc11	UTSW	8	47,983,808 (GRCm39)	missense	possibly damaging	0.95
R6369:Trappc11	UTSW	8	47,965,320 (GRCm39)	splice site	probably null
R7541:Trappc11	UTSW	8	47,958,617 (GRCm39)	splice site	probably null
R7544:Trappc11	UTSW	8	47,975,449 (GRCm39)	missense	possibly damaging	0.73
R7762:Trappc11	UTSW	8	47,975,411 (GRCm39)	missense	probably damaging	0.99
R7964:Trappc11	UTSW	8	47,979,979 (GRCm39)	missense	possibly damaging	0.54
R8183:Trappc11	UTSW	8	47,982,391 (GRCm39)	missense	possibly damaging	0.93
R8282:Trappc11	UTSW	8	47,969,624 (GRCm39)	missense	probably damaging	0.97
R8733:Trappc11	UTSW	8	47,954,883 (GRCm39)	missense	probably damaging	1.00
R8782:Trappc11	UTSW	8	47,951,701 (GRCm39)	missense	probably benign	0.44
R8853:Trappc11	UTSW	8	47,982,439 (GRCm39)	missense	probably damaging	0.98
R9544:Trappc11	UTSW	8	47,972,713 (GRCm39)	missense	possibly damaging	0.94
R9709:Trappc11	UTSW	8	47,946,348 (GRCm39)	missense	probably damaging	0.97

Posted On

2015-04-16