Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02267:Trib1'

286927

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trib1

Ensembl Gene

ENSMUSG00000032501

Gene Name

tribbles pseudokinase 1

Synonyms

A530090O15Rik, Trb1

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02267

Quality Score

Status

Chromosome

Chromosomal Location

59520503-59528948 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 59523449 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 161 (E161G)

Ref Sequence

ENSEMBL: ENSMUSP00000112828 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067543] [ENSMUST00000118228]

AlphaFold

Q8K4K4

Predicted Effect

probably damaging
Transcript: ENSMUST00000067543
AA Change: E161G

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000068834
Gene: ENSMUSG00000032501
AA Change: E161G

Domain	Start	End	E-Value	Type
low complexity region	61	82	N/A	INTRINSIC
Pfam:Pkinase	105	338	1.1e-33	PFAM
Pfam:Pkinase_Tyr	120	335	2.1e-15	PFAM
Pfam:Kinase-like	124	326	1.4e-8	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000118228
AA Change: E161G

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000112828
Gene: ENSMUSG00000032501
AA Change: E161G

Domain	Start	End	E-Value	Type
low complexity region	61	82	N/A	INTRINSIC
Pfam:Pkinase	104	218	7.9e-12	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Macrophages from mice homozygous for a knock-out allele exhibit impaired IL12 response to LPS, MALP-1, or CpG DNA. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts2	A	G	11: 50,683,505 (GRCm39)	Q929R	probably benign	Het
Aplf	A	T	6: 87,635,946 (GRCm39)	D122E	probably damaging	Het
Atp2a3	T	A	11: 72,878,810 (GRCm39)	L874Q	probably damaging	Het
Atp2b2	A	T	6: 113,770,691 (GRCm39)	L406Q	probably damaging	Het
Atp6v1b1	A	G	6: 83,733,891 (GRCm39)	D374G	probably benign	Het
Bcas1	T	A	2: 170,220,708 (GRCm39)	R239*	probably null	Het
Bhmt2	A	G	13: 93,805,854 (GRCm39)	V56A	probably damaging	Het
Cage1	T	C	13: 38,207,233 (GRCm39)	E204G	probably damaging	Het
Ccdc157	G	A	11: 4,094,035 (GRCm39)	A532V	probably benign	Het
Cd300lb	G	A	11: 114,819,303 (GRCm39)	R109*	probably null	Het
Clca4c-ps	T	C	3: 144,585,516 (GRCm39)		noncoding transcript	Het
Ctnna3	G	T	10: 64,781,777 (GRCm39)	V747F	probably benign	Het
Cyp2c29	A	T	19: 39,318,866 (GRCm39)	I488F	probably benign	Het
Cyp3a25	T	C	5: 145,935,362 (GRCm39)	M85V	possibly damaging	Het
Dnah7b	T	A	1: 46,266,090 (GRCm39)	Y2220N	probably damaging	Het
Espl1	A	G	15: 102,224,099 (GRCm39)	I1217V	probably benign	Het
Exoc2	A	G	13: 30,999,304 (GRCm39)	S918P	probably benign	Het
Fer1l4	T	A	2: 155,873,172 (GRCm39)	I1303F	possibly damaging	Het
Gm28047	A	T	15: 102,455,662 (GRCm39)	I234K	probably damaging	Het
Gpcpd1	A	G	2: 132,410,630 (GRCm39)	V19A	probably damaging	Het
Gprin3	A	G	6: 59,331,458 (GRCm39)	V283A	probably benign	Het
Grb14	A	G	2: 64,783,960 (GRCm39)	Y56H	probably damaging	Het
Greb1	A	G	12: 16,767,209 (GRCm39)	F331S	probably benign	Het
Iigp1c	T	G	18: 60,379,470 (GRCm39)	V335G	probably damaging	Het
Jkamp	A	G	12: 72,141,591 (GRCm39)	Y198C	probably damaging	Het
Klk1b11	G	T	7: 43,649,165 (GRCm39)	C234F	probably damaging	Het
Nacad	T	C	11: 6,552,649 (GRCm39)	T181A	probably benign	Het
Or1e23	A	G	11: 73,407,375 (GRCm39)	S217P	probably benign	Het
Or2m13	A	T	16: 19,225,914 (GRCm39)	L285Q	possibly damaging	Het
Or5ak4	T	A	2: 85,161,465 (GRCm39)	Y259F	probably damaging	Het
Pitpnm3	A	T	11: 71,962,274 (GRCm39)	I227N	probably benign	Het
Pnn	A	G	12: 59,116,995 (GRCm39)	E189G	probably damaging	Het
Pnpla2	C	A	7: 141,038,122 (GRCm39)	P197T	probably damaging	Het
Pnpla6	A	G	8: 3,567,327 (GRCm39)	T62A	probably benign	Het
Ptprq	G	T	10: 107,482,419 (GRCm39)	D1051E	probably damaging	Het
Rag2	C	T	2: 101,460,376 (GRCm39)	R229C	probably damaging	Het
Serinc1	A	T	10: 57,399,204 (GRCm39)	I196N	probably damaging	Het
Slc26a4	C	T	12: 31,578,853 (GRCm39)		probably benign	Het
Slc26a9	T	C	1: 131,680,583 (GRCm39)	C43R	probably damaging	Het
Slc2a3	A	T	6: 122,716,931 (GRCm39)	Y44N	probably benign	Het
Smad5	T	G	13: 56,883,603 (GRCm39)		probably benign	Het
Sugct	C	A	13: 17,819,450 (GRCm39)	V132F	possibly damaging	Het
Supt6	T	C	11: 78,117,030 (GRCm39)	E568G	possibly damaging	Het
Tfpt	T	C	7: 3,631,982 (GRCm39)	T43A	probably damaging	Het
Timp4	A	T	6: 115,224,240 (GRCm39)	V143E	possibly damaging	Het
Tns1	T	C	1: 74,031,290 (GRCm39)	D275G	possibly damaging	Het
Trpc7	A	T	13: 57,008,743 (GRCm39)	L308Q	probably damaging	Het
Ush1c	A	T	7: 45,858,722 (GRCm39)	V522E	possibly damaging	Het
Usp28	T	C	9: 48,935,265 (GRCm39)	V449A	probably damaging	Het
Vmn1r82	A	G	7: 12,039,273 (GRCm39)	Y64C	probably damaging	Het
Wwox	G	A	8: 115,438,805 (GRCm39)	M290I	probably benign	Het

Other mutations in Trib1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01140:Trib1	APN	15	59,523,476 (GRCm39)	missense	probably damaging	1.00
IGL01648:Trib1	APN	15	59,526,350 (GRCm39)	missense	probably benign	0.38
IGL03018:Trib1	APN	15	59,526,333 (GRCm39)	missense	probably damaging	1.00
Dibble	UTSW	15	59,526,324 (GRCm39)	missense	probably damaging	1.00
lawrence	UTSW	15	59,521,264 (GRCm39)	missense	probably benign
Topcat	UTSW	15	59,523,487 (GRCm39)	nonsense	probably null
R1994:Trib1	UTSW	15	59,521,192 (GRCm39)	missense	possibly damaging	0.70
R2073:Trib1	UTSW	15	59,526,189 (GRCm39)	missense	probably damaging	1.00
R2407:Trib1	UTSW	15	59,526,449 (GRCm39)	missense	probably benign	0.00
R3709:Trib1	UTSW	15	59,526,210 (GRCm39)	missense	probably damaging	1.00
R5759:Trib1	UTSW	15	59,526,350 (GRCm39)	missense	probably benign
R5986:Trib1	UTSW	15	59,526,451 (GRCm39)	splice site	probably null
R6083:Trib1	UTSW	15	59,526,324 (GRCm39)	missense	probably damaging	1.00
R6084:Trib1	UTSW	15	59,526,324 (GRCm39)	missense	probably damaging	1.00
R6086:Trib1	UTSW	15	59,526,324 (GRCm39)	missense	probably damaging	1.00
R6112:Trib1	UTSW	15	59,523,487 (GRCm39)	nonsense	probably null
R6113:Trib1	UTSW	15	59,523,487 (GRCm39)	nonsense	probably null
R6316:Trib1	UTSW	15	59,521,264 (GRCm39)	missense	probably benign
R7288:Trib1	UTSW	15	59,526,471 (GRCm39)	missense	probably benign
R7663:Trib1	UTSW	15	59,523,562 (GRCm39)	missense	probably damaging	1.00
R7744:Trib1	UTSW	15	59,526,512 (GRCm39)	missense	probably benign	0.04
R8061:Trib1	UTSW	15	59,523,404 (GRCm39)	missense	probably damaging	0.97

Posted On

2015-04-16