Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02269:Tmem45b'

287076

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem45b

Ensembl Gene

ENSMUSG00000041737

Gene Name

transmembrane protein 45b

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL02269

Quality Score

Status

Chromosome

Chromosomal Location

31337492-31375758 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 31339279 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 145 (C145*)

Ref Sequence

ENSEMBL: ENSMUSP00000149691 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048050] [ENSMUST00000213807] [ENSMUST00000217007]

AlphaFold

Q8VCZ2

Predicted Effect

probably null
Transcript: ENSMUST00000048050
AA Change: C231*

SMART Domains

Protein: ENSMUSP00000042313
Gene: ENSMUSG00000041737
AA Change: C231*

Domain	Start	End	E-Value	Type
transmembrane domain	10	27	N/A	INTRINSIC
transmembrane domain	47	69	N/A	INTRINSIC
transmembrane domain	93	115	N/A	INTRINSIC
Pfam:DUF716	117	238	2.8e-37	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213807

Predicted Effect

probably null
Transcript: ENSMUST00000217007
AA Change: C145*

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933414I15Rik	A	G	11: 50,833,425 (GRCm39)	V59A	unknown	Het
A2ml1	C	A	6: 128,530,301 (GRCm39)		probably benign	Het
Akap13	G	A	7: 75,252,659 (GRCm39)	R263H	probably benign	Het
B3galt5	A	G	16: 96,116,730 (GRCm39)	D121G	possibly damaging	Het
Becn1	A	G	11: 101,182,361 (GRCm39)		probably benign	Het
Carmil1	A	T	13: 24,339,393 (GRCm39)	L150*	probably null	Het
Cep170	A	T	1: 176,596,932 (GRCm39)	M475K	probably benign	Het
Cyp24a1	C	T	2: 170,338,492 (GRCm39)	G68D	probably damaging	Het
Cyp3a44	A	T	5: 145,742,547 (GRCm39)	I18N	probably benign	Het
Dmrt2	T	C	19: 25,655,823 (GRCm39)	V474A	probably benign	Het
Dtnb	A	G	12: 3,646,691 (GRCm39)	D64G	probably damaging	Het
Epb41l3	T	C	17: 69,554,568 (GRCm39)	S223P	probably damaging	Het
Ephb2	A	G	4: 136,498,360 (GRCm39)	Y240H	possibly damaging	Het
Extl3	T	C	14: 65,315,032 (GRCm39)	Y50C	probably damaging	Het
Fat3	A	C	9: 15,826,873 (GRCm39)	S4360A	possibly damaging	Het
Fbxo9	A	T	9: 77,994,835 (GRCm39)	V230E	probably damaging	Het
Frmd4a	T	C	2: 4,609,045 (GRCm39)	M971T	probably benign	Het
Gm7275	A	G	16: 47,894,185 (GRCm39)		noncoding transcript	Het
Hyal6	C	T	6: 24,740,858 (GRCm39)	T337I	probably damaging	Het
Obsl1	C	T	1: 75,464,357 (GRCm39)	V1650M	probably damaging	Het
Or1j13	A	T	2: 36,369,579 (GRCm39)	S188T	possibly damaging	Het
Or52z14	T	A	7: 103,253,089 (GRCm39)	I76N	probably damaging	Het
Or7e169	A	T	9: 19,757,024 (GRCm39)	I297N	possibly damaging	Het
Or8c8	A	T	9: 38,165,232 (GRCm39)	D173V	possibly damaging	Het
Pcdh7	A	C	5: 58,070,664 (GRCm39)	E1114A	probably damaging	Het
Pde8a	C	T	7: 80,958,550 (GRCm39)		probably benign	Het
Pdzrn4	A	T	15: 92,667,731 (GRCm39)	S628C	probably damaging	Het
Pear1	C	T	3: 87,663,571 (GRCm39)	G376S	probably damaging	Het
Plekha6	C	T	1: 133,215,587 (GRCm39)	T644M	possibly damaging	Het
Plpp1	T	A	13: 112,993,526 (GRCm39)	C153S	probably damaging	Het
Ptpn3	G	A	4: 57,197,510 (GRCm39)	T793M	possibly damaging	Het
Rdh13	A	T	7: 4,448,497 (GRCm39)	L5Q	possibly damaging	Het
Rimbp2	G	T	5: 128,851,359 (GRCm39)	D862E	probably damaging	Het
Rita1	C	T	5: 120,747,858 (GRCm39)	A147T	probably damaging	Het
Scamp1	C	T	13: 94,368,694 (GRCm39)		probably benign	Het
Scamp3	A	G	3: 89,088,041 (GRCm39)	T178A	probably benign	Het
Sh3tc1	A	G	5: 35,863,628 (GRCm39)	V853A	probably benign	Het
Snrnp200	C	T	2: 127,071,911 (GRCm39)	T1197M	possibly damaging	Het
Sult3a1	T	C	10: 33,755,259 (GRCm39)	F275L	probably benign	Het
Tenm4	A	T	7: 96,473,029 (GRCm39)	I905F	probably damaging	Het
Tgm3	T	A	2: 129,866,438 (GRCm39)	S119T	probably benign	Het
Tmem131l	A	T	3: 83,845,357 (GRCm39)	D424E	possibly damaging	Het
Unc5c	G	A	3: 141,494,743 (GRCm39)	R352H	probably damaging	Het
Vmn2r12	A	G	5: 109,234,343 (GRCm39)	L623P	probably damaging	Het
Vmn2r68	T	C	7: 84,870,947 (GRCm39)	M779V	possibly damaging	Het
Zfhx2	T	C	14: 55,309,393 (GRCm39)	N902S	probably benign	Het

Other mutations in Tmem45b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
PIT4403001:Tmem45b	UTSW	9	31,338,188 (GRCm39)	missense	probably benign	0.01
R0689:Tmem45b	UTSW	9	31,339,879 (GRCm39)	missense	probably benign	0.05
R1845:Tmem45b	UTSW	9	31,342,651 (GRCm39)	missense	probably damaging	0.99
R1874:Tmem45b	UTSW	9	31,340,383 (GRCm39)	missense	probably damaging	1.00
R2147:Tmem45b	UTSW	9	31,340,277 (GRCm39)	missense	probably benign	0.01
R4584:Tmem45b	UTSW	9	31,339,951 (GRCm39)	missense	probably damaging	1.00
R5308:Tmem45b	UTSW	9	31,340,380 (GRCm39)	missense	probably damaging	0.97
R5472:Tmem45b	UTSW	9	31,339,340 (GRCm39)	missense	possibly damaging	0.94
R6564:Tmem45b	UTSW	9	31,339,301 (GRCm39)	missense	probably damaging	1.00
R7140:Tmem45b	UTSW	9	31,345,780 (GRCm39)	splice site	probably null
R7145:Tmem45b	UTSW	9	31,340,337 (GRCm39)	missense	probably damaging	1.00
R7154:Tmem45b	UTSW	9	31,339,328 (GRCm39)	missense	possibly damaging	0.88
R7419:Tmem45b	UTSW	9	31,339,334 (GRCm39)	missense	probably benign	0.01
Z1088:Tmem45b	UTSW	9	31,339,323 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16