Incidental Mutation 'IGL00910:Lratd1'
| ID |
28709 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Lratd1
|
| Ensembl Gene |
ENSMUSG00000020607 |
| Gene Name |
LRAT domain containing 1 |
| Synonyms |
Fam84a, 4731402F03Rik, 2310003N02Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.115)
|
| Stock # |
IGL00910
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
12 |
| Chromosomal Location |
14197599-14202039 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 14200527 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 67
(S67G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000020926
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020926]
[ENSMUST00000221405]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020926
AA Change: S67G
PolyPhen 2
Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000020926
Gene: ENSMUSG00000020607
AA Change: S67G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
57 |
69 |
N/A |
INTRINSIC |
|
low complexity region
|
71 |
81 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000221405
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5031439G07Rik |
A |
G |
15: 84,840,020 (GRCm39) |
L109P |
probably damaging |
Het |
| Aacs |
T |
A |
5: 125,585,772 (GRCm39) |
M316K |
probably benign |
Het |
| Adarb2 |
T |
C |
13: 8,722,469 (GRCm39) |
V375A |
probably damaging |
Het |
| Adgra2 |
C |
A |
8: 27,576,011 (GRCm39) |
A13E |
possibly damaging |
Het |
| Ankrd34c |
A |
T |
9: 89,611,079 (GRCm39) |
S421T |
probably benign |
Het |
| Bpifa6 |
A |
T |
2: 153,832,386 (GRCm39) |
M298L |
probably benign |
Het |
| Casq2 |
T |
C |
3: 102,017,547 (GRCm39) |
|
probably benign |
Het |
| Ckap5 |
A |
G |
2: 91,406,395 (GRCm39) |
T762A |
probably benign |
Het |
| Dhx38 |
A |
G |
8: 110,285,666 (GRCm39) |
V389A |
probably benign |
Het |
| Dnah7b |
A |
T |
1: 46,105,889 (GRCm39) |
|
probably benign |
Het |
| Dnajc7 |
A |
T |
11: 100,490,017 (GRCm39) |
F79L |
possibly damaging |
Het |
| Dyrk3 |
A |
G |
1: 131,064,073 (GRCm39) |
I3T |
possibly damaging |
Het |
| Fchsd2 |
T |
C |
7: 100,926,833 (GRCm39) |
I641T |
probably benign |
Het |
| Furin |
A |
G |
7: 80,040,744 (GRCm39) |
V698A |
probably benign |
Het |
| Prl2c5 |
G |
A |
13: 13,364,061 (GRCm39) |
|
probably null |
Het |
| Ryr3 |
A |
T |
2: 112,559,279 (GRCm39) |
|
probably benign |
Het |
| Serpina6 |
G |
T |
12: 103,618,224 (GRCm39) |
|
probably benign |
Het |
| Slc6a2 |
A |
G |
8: 93,722,728 (GRCm39) |
Y575C |
probably damaging |
Het |
| Trim9 |
T |
C |
12: 70,393,887 (GRCm39) |
E19G |
probably damaging |
Het |
| Tsfm |
G |
T |
10: 126,864,228 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Lratd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01446:Lratd1
|
APN |
12 |
14,199,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02684:Lratd1
|
APN |
12 |
14,200,646 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Grade
|
UTSW |
12 |
14,199,864 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1514:Lratd1
|
UTSW |
12 |
14,199,864 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1583:Lratd1
|
UTSW |
12 |
14,200,409 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1800:Lratd1
|
UTSW |
12 |
14,200,226 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6074:Lratd1
|
UTSW |
12 |
14,200,512 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6259:Lratd1
|
UTSW |
12 |
14,200,646 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7169:Lratd1
|
UTSW |
12 |
14,200,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9239:Lratd1
|
UTSW |
12 |
14,200,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9649:Lratd1
|
UTSW |
12 |
14,200,190 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2013-04-17 |
Incidental Mutation