Incidental Mutation 'IGL02270:Trav15-1-dv6-1'
ID287111
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trav15-1-dv6-1
Ensembl Gene ENSMUSG00000094016
Gene NameT cell receptor alpha variable 15-1-DV6-1
SynonymsGm16591
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.089) question?
Stock #IGL02270
Quality Score
Status
Chromosome14
Chromosomal Location53559676-53560247 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 53559998 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Lysine at position 35 (E35K)
Ref Sequence ENSEMBL: ENSMUSP00000143712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103653] [ENSMUST00000200101]
Predicted Effect possibly damaging
Transcript: ENSMUST00000103653
AA Change: E34K

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000100430
Gene: ENSMUSG00000094016
AA Change: E34K

DomainStartEndE-ValueType
IGv 37 113 4.32e-8 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000200101
AA Change: E35K

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000143712
Gene: ENSMUSG00000094016
AA Change: E35K

DomainStartEndE-ValueType
IGv 38 114 4.32e-8 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 T C 13: 81,559,195 probably null Het
Bmi1 T A 2: 18,684,458 S318T probably benign Het
Cntnap5c G A 17: 58,034,853 V180I probably benign Het
Cyp2b10 A G 7: 25,913,937 E186G probably damaging Het
Ddx25 G T 9: 35,554,412 probably benign Het
Dis3 A G 14: 99,078,354 F901L probably benign Het
Dnah7a T A 1: 53,472,893 N3003I possibly damaging Het
Ebf2 A G 14: 67,238,953 D124G probably damaging Het
Efcab5 A T 11: 77,104,313 I1144N probably damaging Het
Exoc4 G A 6: 33,580,026 V489I possibly damaging Het
Garem1 A G 18: 21,148,450 V283A probably damaging Het
Gfra2 G A 14: 70,925,907 R210H possibly damaging Het
Gli3 T C 13: 15,726,786 probably benign Het
Gm7247 A T 14: 51,521,884 M107L probably benign Het
Map2k5 A T 9: 63,322,197 probably null Het
Mki67 C T 7: 135,698,632 D1558N probably damaging Het
Mylk4 A G 13: 32,729,066 probably benign Het
Olfr1 A G 11: 73,395,365 V219A probably benign Het
Olfr112 G T 17: 37,563,580 H244N possibly damaging Het
Olfr2 A T 7: 107,001,423 C146S probably damaging Het
Olfr669 A G 7: 104,939,369 N281S possibly damaging Het
Plcd1 T C 9: 119,084,641 T50A probably damaging Het
Rasgrp3 A G 17: 75,516,373 R480G probably benign Het
Ripor3 T C 2: 167,993,496 E185G probably damaging Het
S1pr3 T C 13: 51,419,056 I91T probably benign Het
Slc26a4 C T 12: 31,528,854 probably benign Het
Slc28a3 T C 13: 58,580,584 T104A probably benign Het
Slc6a11 A G 6: 114,238,396 D419G probably damaging Het
St3gal2 A G 8: 110,957,766 I19V probably benign Het
Sycp1 C A 3: 102,895,943 C517F probably benign Het
Vmn1r121 T C 7: 21,098,476 E13G probably damaging Het
Vmn1r199 T A 13: 22,383,006 S114T probably damaging Het
Vmn2r-ps159 T C 4: 156,334,655 noncoding transcript Het
Other mutations in Trav15-1-dv6-1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01011:Trav15-1-dv6-1 APN 14 53560035 missense possibly damaging 0.94
IGL02490:Trav15-1-dv6-1 APN 14 53560131 missense probably benign 0.00
IGL03205:Trav15-1-dv6-1 APN 14 53560028 missense probably damaging 1.00
R4607:Trav15-1-dv6-1 UTSW 14 53560054 missense probably benign 0.01
R6188:Trav15-1-dv6-1 UTSW 14 53559957 missense probably damaging 0.99
Posted On2015-04-16