Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02271:Ifitm7'

287120

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifitm7

Ensembl Gene

ENSMUSG00000065968

Gene Name

interferon induced transmembrane protein 7

Synonyms

Mil4, 4933438K12Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

IGL02271

Quality Score

Status

Chromosome

Chromosomal Location

13799566-13804731 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 13801541 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 73 (F73L)

Ref Sequence

ENSEMBL: ENSMUSP00000113641 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056521] [ENSMUST00000117803] [ENSMUST00000118412] [ENSMUST00000131608] [ENSMUST00000178021]

AlphaFold

G3X9Z2

Predicted Effect

probably benign
Transcript: ENSMUST00000056521

SMART Domains

Protein: ENSMUSP00000062758
Gene: ENSMUSG00000044117

Domain	Start	End	E-Value	Type
DUF3585	10	149	5.68e-39	SMART
low complexity region	170	181	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000117803
AA Change: F73L

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000113641
Gene: ENSMUSG00000065968
AA Change: F73L

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:Dispanin	46	128	5.6e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000118412

SMART Domains

Protein: ENSMUSP00000112435
Gene: ENSMUSG00000044117

Domain	Start	End	E-Value	Type
DUF3585	10	112	1.07e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000131608

SMART Domains

Protein: ENSMUSP00000122790
Gene: ENSMUSG00000044117

Domain	Start	End	E-Value	Type
DUF3585	1	81	2.82e-2	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000178021
AA Change: F45L

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000136512
Gene: ENSMUSG00000065968
AA Change: F45L

Domain	Start	End	E-Value	Type
Pfam:Dispanin	18	100	7.2e-27	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230206

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Astn1	C	T	1: 158,338,520 (GRCm39)		probably benign	Het
Bms1	C	A	6: 118,366,290 (GRCm39)	V1068F	probably benign	Het
Cand1	A	T	10: 119,047,626 (GRCm39)	N621K	probably damaging	Het
Cd44	C	T	2: 102,661,732 (GRCm39)	E418K	possibly damaging	Het
Clip2	A	T	5: 134,531,425 (GRCm39)	N758K	probably benign	Het
Cst11	A	T	2: 148,613,161 (GRCm39)	Y55N	probably damaging	Het
Cytip	A	T	2: 58,023,872 (GRCm39)	L316*	probably null	Het
Ddx52	T	C	11: 83,843,057 (GRCm39)	M352T	probably damaging	Het
Fancd2	G	A	6: 113,512,720 (GRCm39)		probably benign	Het
Fat4	A	T	3: 39,034,068 (GRCm39)	E2573D	probably benign	Het
Fbxl13	T	G	5: 21,695,454 (GRCm39)	D646A	probably damaging	Het
Fhdc1	G	A	3: 84,352,042 (GRCm39)	A1061V	possibly damaging	Het
Grid2ip	A	G	5: 143,374,664 (GRCm39)	D928G	probably benign	Het
Hmgxb3	A	G	18: 61,265,285 (GRCm39)	L1231P	probably damaging	Het
Ikbkb	T	A	8: 23,155,919 (GRCm39)	T583S	probably benign	Het
Kdm6b	G	A	11: 69,296,893 (GRCm39)	A458V	possibly damaging	Het
Klra2	T	C	6: 131,207,180 (GRCm39)	K143R	probably benign	Het
Kmt2d	A	G	15: 98,764,309 (GRCm39)	S42P	possibly damaging	Het
Krt78	T	A	15: 101,857,028 (GRCm39)	M360L	probably benign	Het
Lamb1	A	G	12: 31,350,250 (GRCm39)	N677S	probably damaging	Het
Lrrc9	G	A	12: 72,557,155 (GRCm39)	V1407I	probably benign	Het
Myo6	A	G	9: 80,168,113 (GRCm39)	T426A	probably benign	Het
Net1	T	C	13: 3,937,663 (GRCm39)	Y146C	probably damaging	Het
Nlrp4d	T	A	7: 10,122,625 (GRCm39)		noncoding transcript	Het
Notch4	A	T	17: 34,787,445 (GRCm39)	N335I	probably damaging	Het
Or14j6	A	T	17: 38,215,134 (GRCm39)	E232D	probably benign	Het
Or5ac20	A	T	16: 59,104,584 (GRCm39)	I92K	probably damaging	Het
Or8b53	A	T	9: 38,667,784 (GRCm39)	T267S	probably benign	Het
Pax3	A	T	1: 78,171,969 (GRCm39)	H80Q	probably damaging	Het
Pclo	A	T	5: 14,729,508 (GRCm39)		probably benign	Het
Pdgfra	A	G	5: 75,348,567 (GRCm39)	D869G	probably damaging	Het
Per2	T	C	1: 91,373,332 (GRCm39)	Y152C	probably damaging	Het
Pilrb2	T	C	5: 137,865,125 (GRCm39)	D223G	probably benign	Het
Rag1	T	A	2: 101,473,733 (GRCm39)	I470F	probably damaging	Het
Rap1gap	T	C	4: 137,445,317 (GRCm39)	S333P	probably damaging	Het
Rundc3b	A	G	5: 8,542,530 (GRCm39)	Y430H	probably damaging	Het
Ryr1	T	C	7: 28,793,472 (GRCm39)	D1332G	probably benign	Het
Sgo1	G	A	17: 53,986,567 (GRCm39)	A208V	possibly damaging	Het
Skint5	C	T	4: 113,794,778 (GRCm39)		probably null	Het
Slc26a4	C	T	12: 31,578,853 (GRCm39)		probably benign	Het
Slc28a3	A	T	13: 58,706,451 (GRCm39)	S597T	probably benign	Het
Slc4a5	T	A	6: 83,248,085 (GRCm39)		probably benign	Het
Slc52a3	A	G	2: 151,847,448 (GRCm39)		probably benign	Het
Stac3	A	G	10: 127,339,768 (GRCm39)	D158G	probably benign	Het
Tdo2	T	C	3: 81,871,224 (GRCm39)		probably benign	Het
Usp25	A	T	16: 76,912,335 (GRCm39)	E1018V	probably damaging	Het
Vmn1r46	T	A	6: 89,953,886 (GRCm39)	F245Y	probably damaging	Het

Other mutations in Ifitm7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
PIT4283001:Ifitm7	UTSW	16	13,801,471 (GRCm39)	missense	probably damaging	0.98
R6664:Ifitm7	UTSW	16	13,801,613 (GRCm39)	missense	probably benign	0.13
R7129:Ifitm7	UTSW	16	13,801,600 (GRCm39)	missense	possibly damaging	0.92
R7794:Ifitm7	UTSW	16	13,801,610 (GRCm39)	missense	probably benign	0.03

Posted On

2015-04-16