Incidental Mutation 'IGL02272:Klhl25'
ID287197
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klhl25
Ensembl Gene ENSMUSG00000055652
Gene Namekelch-like 25
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.310) question?
Stock #IGL02272
Quality Score
Status
Chromosome7
Chromosomal Location75848310-75874131 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 75866620 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 425 (T425A)
Ref Sequence ENSEMBL: ENSMUSP00000146102 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092073] [ENSMUST00000171155] [ENSMUST00000205612] [ENSMUST00000205887] [ENSMUST00000206019]
Predicted Effect probably benign
Transcript: ENSMUST00000092073
AA Change: T425A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000089707
Gene: ENSMUSG00000055652
AA Change: T425A

DomainStartEndE-ValueType
BTB 46 144 2.43e-28 SMART
BACK 149 251 1.06e-32 SMART
Blast:BTB 256 294 1e-9 BLAST
Kelch 296 340 1.4e0 SMART
Kelch 341 388 6.71e-10 SMART
Kelch 389 444 2.25e-11 SMART
Kelch 445 492 1.22e-1 SMART
Kelch 493 538 1.92e-5 SMART
Kelch 539 585 1.4e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000171155
AA Change: T425A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000133175
Gene: ENSMUSG00000055652
AA Change: T425A

DomainStartEndE-ValueType
BTB 46 144 2.43e-28 SMART
BACK 149 251 1.06e-32 SMART
Blast:BTB 256 294 1e-9 BLAST
Kelch 296 340 1.4e0 SMART
Kelch 341 388 6.71e-10 SMART
Kelch 389 444 2.25e-11 SMART
Kelch 445 492 1.22e-1 SMART
Kelch 493 538 1.92e-5 SMART
Kelch 539 585 1.4e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205612
AA Change: T120A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000205887
Predicted Effect probably benign
Transcript: ENSMUST00000206019
AA Change: T425A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206418
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre1 T A 17: 57,450,021 C759* probably null Het
Adgrg6 T A 10: 14,468,829 M127L probably damaging Het
AI314180 A T 4: 58,811,731 N1439K probably benign Het
Anxa9 A G 3: 95,305,894 V47A probably benign Het
Arhgef12 T A 9: 43,001,452 D483V probably damaging Het
Arrdc3 C A 13: 80,891,650 probably benign Het
Ccdc169 A G 3: 55,150,748 E67G probably damaging Het
Ccdc191 T A 16: 43,960,022 V731D possibly damaging Het
Cdh3 G T 8: 106,547,836 probably null Het
Cntnap1 G A 11: 101,178,316 V199M probably damaging Het
Cntnap3 A T 13: 64,757,411 V852E probably damaging Het
Csmd1 A T 8: 16,199,893 S1024T probably damaging Het
Cyp3a25 T C 5: 145,993,265 probably benign Het
Dusp6 T A 10: 99,266,019 V289D probably damaging Het
Epha6 C T 16: 59,818,937 R858Q probably damaging Het
Flrt2 T A 12: 95,779,704 F272Y probably damaging Het
Gbf1 T A 19: 46,269,803 W846R probably damaging Het
Gtpbp2 T A 17: 46,164,781 V152E probably benign Het
Hmces A G 6: 87,917,855 probably null Het
Hsph1 A G 5: 149,617,530 S852P probably benign Het
Kat6b A C 14: 21,626,778 K394Q probably damaging Het
Kdr G A 5: 75,961,840 T475I probably benign Het
Klk1b8 T A 7: 43,952,793 C50S probably damaging Het
Kri1 T C 9: 21,276,168 Y343C probably damaging Het
Lamb1 T C 12: 31,305,769 S953P probably benign Het
Lpin1 A G 12: 16,547,600 V681A probably damaging Het
Lpin3 A G 2: 160,901,661 T508A probably benign Het
Moxd1 T A 10: 24,282,700 Y417* probably null Het
Mthfd1l T G 10: 4,041,812 I588S probably damaging Het
Myo5c C A 9: 75,266,160 N543K possibly damaging Het
Myo9a T A 9: 59,884,600 probably benign Het
Nme8 T C 13: 19,658,826 Y393C probably damaging Het
Nr2e1 T G 10: 42,567,979 N249T probably damaging Het
Pex11g A G 8: 3,465,898 V45A probably benign Het
Pkhd1 C A 1: 20,209,260 G2945W probably damaging Het
Plxnd1 A G 6: 115,993,628 F393S probably damaging Het
Ppp3cc A G 14: 70,236,489 V353A probably damaging Het
Prss16 T A 13: 22,003,035 Q455L probably damaging Het
Ptpn6 A T 6: 124,721,208 V524E probably damaging Het
Rap1gap A G 4: 137,716,566 Y163C probably damaging Het
Rnf31 C T 14: 55,598,782 L598F probably damaging Het
Sardh T G 2: 27,224,991 D550A probably benign Het
Serpinc1 T G 1: 160,999,992 I387S probably damaging Het
Sh3d19 A T 3: 86,121,167 D650V probably benign Het
Sipa1l2 T A 8: 125,492,011 T196S probably damaging Het
Slc25a46 T C 18: 31,583,568 T294A probably benign Het
Srrm2 T C 17: 23,815,782 probably benign Het
Steap2 T A 5: 5,677,612 N241I probably benign Het
Tcaf3 T C 6: 42,596,660 Y206C probably damaging Het
Tmem259 T A 10: 79,978,463 Q322L probably damaging Het
Tnni2 C A 7: 142,443,429 Q52K possibly damaging Het
Ttn A G 2: 76,735,028 V28285A possibly damaging Het
Uba7 T A 9: 107,976,153 S99R probably benign Het
Ubxn2b A T 4: 6,216,071 K331N probably damaging Het
Usp50 G A 2: 126,769,944 T232I probably damaging Het
Vmn2r116 G A 17: 23,385,999 M95I probably benign Het
Vmn2r116 T A 17: 23,386,004 L97Q probably damaging Het
Vmn2r24 A T 6: 123,786,884 N240I possibly damaging Het
Vmn2r72 T C 7: 85,750,693 R383G probably benign Het
Other mutations in Klhl25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01068:Klhl25 APN 7 75866149 nonsense probably null
IGL01142:Klhl25 APN 7 75866596 missense probably damaging 1.00
IGL01295:Klhl25 APN 7 75865872 missense probably benign 0.20
IGL02721:Klhl25 APN 7 75866900 missense probably damaging 1.00
R0196:Klhl25 UTSW 7 75865702 missense probably damaging 1.00
R0365:Klhl25 UTSW 7 75866516 missense probably damaging 1.00
R0828:Klhl25 UTSW 7 75866195 missense probably damaging 0.99
R0881:Klhl25 UTSW 7 75866279 missense probably damaging 1.00
R1061:Klhl25 UTSW 7 75866520 nonsense probably null
R1228:Klhl25 UTSW 7 75866120 missense probably benign
R1696:Klhl25 UTSW 7 75866843 missense probably damaging 1.00
R1991:Klhl25 UTSW 7 75866732 missense probably damaging 1.00
R2118:Klhl25 UTSW 7 75866732 missense probably damaging 1.00
R4359:Klhl25 UTSW 7 75866732 missense probably damaging 1.00
R4428:Klhl25 UTSW 7 75865414 missense probably damaging 0.97
R4431:Klhl25 UTSW 7 75865414 missense probably damaging 0.97
R4717:Klhl25 UTSW 7 75866780 missense probably damaging 1.00
R4860:Klhl25 UTSW 7 75867050 missense probably benign 0.03
R4860:Klhl25 UTSW 7 75867050 missense probably benign 0.03
R5619:Klhl25 UTSW 7 75866854 missense probably benign 0.22
R5637:Klhl25 UTSW 7 75865792 intron probably null
R5652:Klhl25 UTSW 7 75866147 missense probably benign 0.06
R5840:Klhl25 UTSW 7 75866692 missense possibly damaging 0.92
R6693:Klhl25 UTSW 7 75866813 missense possibly damaging 0.91
R6723:Klhl25 UTSW 7 75865991 missense possibly damaging 0.64
R6875:Klhl25 UTSW 7 75866342 missense probably damaging 1.00
Posted On2015-04-16