Incidental Mutation 'IGL02302:Or2a25'
ID 287437
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2a25
Ensembl Gene ENSMUSG00000045708
Gene Name olfactory receptor family 2 subfamily A member 25
Synonyms GA_x6K02T2P3E9-4647978-4647046, MOR261-1, Olfr447
Accession Numbers
Essential gene? Probably non essential (E-score: 0.226) question?
Stock # IGL02302
Quality Score
Status
Chromosome 6
Chromosomal Location 42888459-42889391 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 42889272 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 272 (Y272N)
Ref Sequence ENSEMBL: ENSMUSP00000149325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055763] [ENSMUST00000216408]
AlphaFold Q8VGP6
Predicted Effect probably damaging
Transcript: ENSMUST00000055763
AA Change: Y272N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052312
Gene: ENSMUSG00000045708
AA Change: Y272N

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 1.8e-60 PFAM
Pfam:7tm_1 40 289 6.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216408
AA Change: Y272N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700066M21Rik A T 1: 57,422,257 (GRCm39) Q211L possibly damaging Het
Abca14 T A 7: 119,917,968 (GRCm39) probably benign Het
Abcb10 A T 8: 124,685,411 (GRCm39) V543D possibly damaging Het
Ankrd17 G A 5: 90,431,057 (GRCm39) T909I probably benign Het
Arhgef3 A G 14: 27,084,799 (GRCm39) N76S probably benign Het
Bbx A T 16: 50,045,278 (GRCm39) C320S probably damaging Het
Castor2 G A 5: 134,164,482 (GRCm39) V148I possibly damaging Het
Cdh23 C A 10: 60,159,302 (GRCm39) V2159F possibly damaging Het
Cmtr2 G A 8: 110,948,136 (GRCm39) A149T probably damaging Het
Cntnap4 A G 8: 113,512,535 (GRCm39) probably benign Het
Col6a3 A T 1: 90,709,482 (GRCm39) F1905I unknown Het
Ddx60 A G 8: 62,428,866 (GRCm39) Y792C possibly damaging Het
Dennd2b A G 7: 109,124,538 (GRCm39) V1101A probably damaging Het
Dock4 T C 12: 40,775,776 (GRCm39) L573P probably damaging Het
Dop1b A G 16: 93,607,005 (GRCm39) I2103V probably benign Het
Ear1 T G 14: 44,056,504 (GRCm39) Q121H probably benign Het
Eprs1 T A 1: 185,119,321 (GRCm39) probably benign Het
Ero1a T C 14: 45,530,619 (GRCm39) K271R probably benign Het
Esyt1 A G 10: 128,348,236 (GRCm39) L884P probably damaging Het
F2r T C 13: 95,741,160 (GRCm39) N125S probably damaging Het
Fam217a T C 13: 35,095,144 (GRCm39) E357G probably damaging Het
Gabbr1 C T 17: 37,365,689 (GRCm39) R123W probably damaging Het
Gimap4 T G 6: 48,667,347 (GRCm39) V34G probably damaging Het
Gm3248 A T 14: 5,943,011 (GRCm38) V180E probably benign Het
Hecw2 A T 1: 53,972,407 (GRCm39) N204K probably damaging Het
Ighv1-84 T A 12: 115,944,549 (GRCm39) K42* probably null Het
Kcnh7 T A 2: 62,536,402 (GRCm39) Q1060L probably damaging Het
Kif3b T A 2: 153,158,868 (GRCm39) I223N probably damaging Het
Lama2 G A 10: 27,088,039 (GRCm39) P913S probably benign Het
Lgr4 A G 2: 109,832,841 (GRCm39) I334M probably damaging Het
Lrrc45 G T 11: 120,609,351 (GRCm39) E403D possibly damaging Het
Mccc2 A G 13: 100,090,747 (GRCm39) L462P probably damaging Het
Mfsd13b T C 7: 120,598,132 (GRCm39) V346A probably damaging Het
Muc6 T C 7: 141,227,763 (GRCm39) T1342A possibly damaging Het
Mxd3 T C 13: 55,477,091 (GRCm39) N56S probably benign Het
Niban2 A G 2: 32,811,135 (GRCm39) I382V probably benign Het
Ntn5 G T 7: 45,343,672 (GRCm39) R337L probably damaging Het
Nynrin A G 14: 56,105,962 (GRCm39) K894E probably benign Het
Or1j4 G T 2: 36,740,715 (GRCm39) G219V probably benign Het
Or4f56 A C 2: 111,703,887 (GRCm39) S104R possibly damaging Het
Or7e168 A T 9: 19,719,981 (GRCm39) R122S probably damaging Het
Pappa2 T C 1: 158,542,571 (GRCm39) D1772G probably benign Het
Pcdh18 G T 3: 49,710,387 (GRCm39) F309L probably benign Het
Pcdhac2 G T 18: 37,279,006 (GRCm39) R662L probably damaging Het
Ppp5c G A 7: 16,742,555 (GRCm39) S261L possibly damaging Het
Qng1 G A 13: 58,529,749 (GRCm39) R288W probably damaging Het
Rc3h1 T C 1: 160,765,675 (GRCm39) probably benign Het
Rfx8 A C 1: 39,704,682 (GRCm39) S578A possibly damaging Het
Rhbdl3 T G 11: 80,244,507 (GRCm39) *405E probably null Het
Rita1 C T 5: 120,747,858 (GRCm39) A147T probably damaging Het
Rnf139 G T 15: 58,770,606 (GRCm39) L210F probably damaging Het
Rragc A G 4: 123,814,879 (GRCm39) R192G possibly damaging Het
Ryr3 A T 2: 112,794,701 (GRCm39) V137E probably damaging Het
S100pbp A T 4: 129,076,234 (GRCm39) D30E probably damaging Het
Smchd1 A T 17: 71,665,128 (GRCm39) probably benign Het
Sppl3 T A 5: 115,220,390 (GRCm39) C101S probably benign Het
St8sia6 T C 2: 13,728,324 (GRCm39) T74A probably benign Het
Sult3a1 A G 10: 33,742,571 (GRCm39) N66S possibly damaging Het
Sv2b T A 7: 74,773,947 (GRCm39) K508M probably damaging Het
Terf1 T C 1: 15,903,626 (GRCm39) S275P probably damaging Het
Tmed8 G T 12: 87,220,990 (GRCm39) H199N probably damaging Het
Tubg2 A T 11: 101,046,971 (GRCm39) Q9L probably damaging Het
Ubxn4 C T 1: 128,183,848 (GRCm39) probably benign Het
Usp34 C T 11: 23,417,243 (GRCm39) T2964I possibly damaging Het
Zfp213 A G 17: 23,776,945 (GRCm39) S366P possibly damaging Het
Other mutations in Or2a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02604:Or2a25 APN 6 42,888,992 (GRCm39) nonsense probably null
IGL02894:Or2a25 APN 6 42,888,451 (GRCm39) splice site probably benign
R0122:Or2a25 UTSW 6 42,888,889 (GRCm39) missense probably benign 0.00
R0172:Or2a25 UTSW 6 42,888,913 (GRCm39) missense probably benign 0.00
R0371:Or2a25 UTSW 6 42,888,872 (GRCm39) missense probably benign 0.14
R1709:Or2a25 UTSW 6 42,889,078 (GRCm39) missense possibly damaging 0.94
R2431:Or2a25 UTSW 6 42,888,946 (GRCm39) missense probably damaging 0.99
R3809:Or2a25 UTSW 6 42,889,271 (GRCm39) missense probably damaging 1.00
R4032:Or2a25 UTSW 6 42,888,559 (GRCm39) missense probably benign 0.08
R4242:Or2a25 UTSW 6 42,888,480 (GRCm39) missense possibly damaging 0.77
R4369:Or2a25 UTSW 6 42,889,211 (GRCm39) nonsense probably null
R4401:Or2a25 UTSW 6 42,889,260 (GRCm39) nonsense probably null
R4565:Or2a25 UTSW 6 42,888,472 (GRCm39) missense probably benign
R5646:Or2a25 UTSW 6 42,888,457 (GRCm39) splice site probably null
R5968:Or2a25 UTSW 6 42,888,480 (GRCm39) missense probably benign
R6804:Or2a25 UTSW 6 42,888,852 (GRCm39) missense probably benign
R6925:Or2a25 UTSW 6 42,888,791 (GRCm39) nonsense probably null
R8170:Or2a25 UTSW 6 42,889,125 (GRCm39) missense possibly damaging 0.73
R8358:Or2a25 UTSW 6 42,888,976 (GRCm39) missense possibly damaging 0.51
R8765:Or2a25 UTSW 6 42,889,102 (GRCm39) missense probably benign 0.34
R9005:Or2a25 UTSW 6 42,889,170 (GRCm39) missense probably damaging 1.00
R9015:Or2a25 UTSW 6 42,888,825 (GRCm39) missense possibly damaging 0.55
R9308:Or2a25 UTSW 6 42,888,931 (GRCm39) missense probably damaging 1.00
R9520:Or2a25 UTSW 6 42,889,051 (GRCm39) missense probably damaging 0.98
R9743:Or2a25 UTSW 6 42,888,835 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16