Incidental Mutation 'IGL02303:Zc3h4'
ID 287480
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zc3h4
Ensembl Gene ENSMUSG00000059273
Gene Name zinc finger CCCH-type containing 4
Synonyms Kiaa1064-hp, Bwq1, LOC330474
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02303
Quality Score
Status
Chromosome 7
Chromosomal Location 16134835-16171621 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 16168002 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 704 (S704P)
Ref Sequence ENSEMBL: ENSMUSP00000147665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098789] [ENSMUST00000209289]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000098789
AA Change: S779P
SMART Domains Protein: ENSMUSP00000096386
Gene: ENSMUSG00000059273
AA Change: S779P

DomainStartEndE-ValueType
low complexity region 2 22 N/A INTRINSIC
low complexity region 35 97 N/A INTRINSIC
low complexity region 144 170 N/A INTRINSIC
low complexity region 184 247 N/A INTRINSIC
low complexity region 264 324 N/A INTRINSIC
ZnF_C3H1 341 366 1.95e-3 SMART
ZnF_C3H1 370 395 6.17e-6 SMART
ZnF_C3H1 396 419 3.38e-1 SMART
low complexity region 433 451 N/A INTRINSIC
low complexity region 456 486 N/A INTRINSIC
low complexity region 489 505 N/A INTRINSIC
low complexity region 552 641 N/A INTRINSIC
low complexity region 705 720 N/A INTRINSIC
coiled coil region 729 760 N/A INTRINSIC
internal_repeat_2 767 822 3.38e-5 PROSPERO
low complexity region 837 850 N/A INTRINSIC
low complexity region 863 880 N/A INTRINSIC
low complexity region 881 892 N/A INTRINSIC
internal_repeat_2 986 1037 3.38e-5 PROSPERO
low complexity region 1049 1072 N/A INTRINSIC
low complexity region 1077 1097 N/A INTRINSIC
low complexity region 1175 1195 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000209289
AA Change: S704P
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A G 11: 110,045,376 (GRCm39) F319S probably damaging Het
Ap3b1 A G 13: 94,664,827 (GRCm39) D922G unknown Het
Bhlhe41 A T 6: 145,809,882 (GRCm39) H107Q probably damaging Het
Csmd2 C A 4: 128,262,801 (GRCm39) H662Q probably benign Het
Dnah8 T C 17: 30,932,021 (GRCm39) V1463A probably benign Het
Ebf3 A T 7: 136,911,094 (GRCm39) V140E probably benign Het
Havcr2 T A 11: 46,370,108 (GRCm39) probably benign Het
Hexb G A 13: 97,313,401 (GRCm39) A485V probably damaging Het
Igkv5-37 T A 6: 69,940,473 (GRCm39) Q57L probably damaging Het
Ipo5 T A 14: 121,154,795 (GRCm39) S40T probably benign Het
Kcnj8 A G 6: 142,515,837 (GRCm39) M90T probably benign Het
Kif21b T A 1: 136,087,495 (GRCm39) L937Q probably damaging Het
Kmt2c A C 5: 25,515,155 (GRCm39) L2896R probably damaging Het
Ldlrap1 A T 4: 134,484,706 (GRCm39) I96N probably damaging Het
Leo1 A G 9: 75,353,281 (GRCm39) probably benign Het
Mbnl2 T C 14: 120,642,059 (GRCm39) M341T probably benign Het
Nfatc2 G A 2: 168,348,821 (GRCm39) R669* probably null Het
Nhlrc2 T A 19: 56,563,280 (GRCm39) V293E probably damaging Het
Or1e17 T C 11: 73,831,276 (GRCm39) F68S possibly damaging Het
Or2at1 A G 7: 99,417,179 (GRCm39) D270G possibly damaging Het
Or51ag1 A T 7: 103,155,295 (GRCm39) M286K probably benign Het
Or51ai2 A G 7: 103,586,770 (GRCm39) Q61R possibly damaging Het
Otoa T A 7: 120,732,147 (GRCm39) probably null Het
Pcnt T C 10: 76,278,393 (GRCm39) probably benign Het
Recql4 G T 15: 76,592,771 (GRCm39) Q307K possibly damaging Het
Sp140 T A 1: 85,570,730 (GRCm39) Y453* probably null Het
Sspo G A 6: 48,461,639 (GRCm39) V3600I possibly damaging Het
Sybu T C 15: 44,536,619 (GRCm39) E441G probably benign Het
Syne3 A T 12: 104,929,553 (GRCm39) H222Q probably damaging Het
Tef T C 15: 81,705,496 (GRCm39) V173A probably benign Het
Tlcd1 A G 11: 78,071,160 (GRCm39) probably null Het
Tmod4 C A 3: 95,032,953 (GRCm39) Q30K probably benign Het
Tpgs1 T C 10: 79,511,322 (GRCm39) Y155H probably damaging Het
Trib3 G A 2: 152,185,070 (GRCm39) P60S probably benign Het
Ttn T A 2: 76,560,550 (GRCm39) T20957S probably damaging Het
Vars1 T C 17: 35,234,460 (GRCm39) probably benign Het
Vps13c T C 9: 67,852,763 (GRCm39) probably benign Het
Zfp644 G A 5: 106,785,180 (GRCm39) R456W probably damaging Het
Other mutations in Zc3h4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Zc3h4 APN 7 16,156,159 (GRCm39) missense unknown
IGL00923:Zc3h4 APN 7 16,163,617 (GRCm39) missense unknown
IGL01541:Zc3h4 APN 7 16,168,257 (GRCm39) missense unknown
IGL02115:Zc3h4 APN 7 16,159,708 (GRCm39) missense unknown
IGL02336:Zc3h4 APN 7 16,159,702 (GRCm39) missense unknown
IGL02734:Zc3h4 APN 7 16,157,849 (GRCm39) missense unknown
IGL02736:Zc3h4 APN 7 16,151,308 (GRCm39) nonsense probably null
BB008:Zc3h4 UTSW 7 16,166,909 (GRCm39) missense unknown
BB018:Zc3h4 UTSW 7 16,166,909 (GRCm39) missense unknown
R0032:Zc3h4 UTSW 7 16,168,565 (GRCm39) missense unknown
R0032:Zc3h4 UTSW 7 16,168,565 (GRCm39) missense unknown
R0220:Zc3h4 UTSW 7 16,163,198 (GRCm39) missense unknown
R0336:Zc3h4 UTSW 7 16,169,103 (GRCm39) missense unknown
R0416:Zc3h4 UTSW 7 16,154,200 (GRCm39) missense probably damaging 1.00
R0666:Zc3h4 UTSW 7 16,168,697 (GRCm39) missense unknown
R0864:Zc3h4 UTSW 7 16,154,104 (GRCm39) missense probably damaging 0.99
R1068:Zc3h4 UTSW 7 16,163,161 (GRCm39) missense unknown
R1145:Zc3h4 UTSW 7 16,150,838 (GRCm39) missense possibly damaging 0.53
R1145:Zc3h4 UTSW 7 16,150,838 (GRCm39) missense possibly damaging 0.53
R1472:Zc3h4 UTSW 7 16,168,695 (GRCm39) missense unknown
R1665:Zc3h4 UTSW 7 16,163,505 (GRCm39) missense unknown
R2087:Zc3h4 UTSW 7 16,150,865 (GRCm39) missense possibly damaging 0.72
R2182:Zc3h4 UTSW 7 16,156,441 (GRCm39) missense unknown
R2508:Zc3h4 UTSW 7 16,168,264 (GRCm39) missense unknown
R3037:Zc3h4 UTSW 7 16,155,410 (GRCm39) missense unknown
R4439:Zc3h4 UTSW 7 16,163,036 (GRCm39) missense unknown
R4576:Zc3h4 UTSW 7 16,168,579 (GRCm39) missense unknown
R5030:Zc3h4 UTSW 7 16,156,155 (GRCm39) missense unknown
R5160:Zc3h4 UTSW 7 16,168,573 (GRCm39) missense unknown
R5270:Zc3h4 UTSW 7 16,168,440 (GRCm39) missense unknown
R5490:Zc3h4 UTSW 7 16,162,930 (GRCm39) missense unknown
R5519:Zc3h4 UTSW 7 16,169,157 (GRCm39) missense unknown
R5770:Zc3h4 UTSW 7 16,163,536 (GRCm39) missense unknown
R7067:Zc3h4 UTSW 7 16,162,976 (GRCm39) nonsense probably null
R7234:Zc3h4 UTSW 7 16,162,961 (GRCm39) missense unknown
R7316:Zc3h4 UTSW 7 16,169,260 (GRCm39) missense unknown
R7771:Zc3h4 UTSW 7 16,163,824 (GRCm39) missense unknown
R7852:Zc3h4 UTSW 7 16,156,392 (GRCm39) missense unknown
R7922:Zc3h4 UTSW 7 16,159,647 (GRCm39) missense unknown
R7931:Zc3h4 UTSW 7 16,166,909 (GRCm39) missense unknown
R7965:Zc3h4 UTSW 7 16,163,770 (GRCm39) missense unknown
R8827:Zc3h4 UTSW 7 16,163,123 (GRCm39) missense unknown
R8859:Zc3h4 UTSW 7 16,168,939 (GRCm39) missense unknown
R9457:Zc3h4 UTSW 7 16,168,675 (GRCm39) missense unknown
R9562:Zc3h4 UTSW 7 16,168,891 (GRCm39) missense unknown
R9609:Zc3h4 UTSW 7 16,150,751 (GRCm39) missense unknown
R9721:Zc3h4 UTSW 7 16,168,770 (GRCm39) missense unknown
RF001:Zc3h4 UTSW 7 16,163,612 (GRCm39) small insertion probably benign
RF039:Zc3h4 UTSW 7 16,163,543 (GRCm39) small deletion probably benign
X0064:Zc3h4 UTSW 7 16,156,441 (GRCm39) missense unknown
Posted On 2015-04-16