Incidental Mutation 'IGL02305:Zfp438'
ID 287537
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp438
Ensembl Gene ENSMUSG00000050945
Gene Name zinc finger protein 438
Synonyms 9430091M14Rik, B830013J05Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # IGL02305
Quality Score
Status
Chromosome 18
Chromosomal Location 5210029-5334807 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 5213674 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 428 (V428A)
Ref Sequence ENSEMBL: ENSMUSP00000067049 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063989]
AlphaFold Q8BFX2
Predicted Effect possibly damaging
Transcript: ENSMUST00000063989
AA Change: V428A

PolyPhen 2 Score 0.838 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000067049
Gene: ENSMUSG00000050945
AA Change: V428A

DomainStartEndE-ValueType
low complexity region 132 151 N/A INTRINSIC
low complexity region 263 274 N/A INTRINSIC
low complexity region 427 439 N/A INTRINSIC
ZnF_C2H2 493 515 5.72e-1 SMART
ZnF_C2H2 521 543 7.26e-3 SMART
ZnF_C2H2 553 576 5.2e0 SMART
ZnF_C2H2 635 658 1.86e1 SMART
ZnF_C2H2 746 769 1.13e1 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 G A 13: 70,921,048 (GRCm39) T599I probably damaging Het
Ahi1 A G 10: 20,846,796 (GRCm39) T409A probably benign Het
Apol10b T A 15: 77,469,630 (GRCm39) R182S possibly damaging Het
Arhgap35 A G 7: 16,297,590 (GRCm39) F492L probably benign Het
Ccdc136 A G 6: 29,406,173 (GRCm39) D173G probably damaging Het
Ccndbp1 T C 2: 120,841,933 (GRCm39) L67P probably damaging Het
Dync2h1 C T 9: 7,122,678 (GRCm39) V2093I probably benign Het
Eps15l1 T C 8: 73,140,853 (GRCm39) K213R probably null Het
Fat4 A T 3: 39,064,137 (GRCm39) N4698Y probably damaging Het
Frmpd1 G T 4: 45,249,209 (GRCm39) R133L probably damaging Het
Gdi2 T A 13: 3,606,428 (GRCm39) M158K probably damaging Het
Hoxc8 A G 15: 102,901,025 (GRCm39) Y156C probably damaging Het
Iho1 A T 9: 108,283,031 (GRCm39) M219K possibly damaging Het
Kcnh2 T C 5: 24,527,658 (GRCm39) D898G possibly damaging Het
Kng2 T C 16: 22,819,374 (GRCm39) probably benign Het
Men1 T C 19: 6,390,168 (GRCm39) L566P probably damaging Het
Mtmr2 T C 9: 13,706,551 (GRCm39) W153R probably damaging Het
Mug2 T G 6: 122,013,015 (GRCm39) L309R probably benign Het
Myo7a A G 7: 97,700,836 (GRCm39) *2165R probably null Het
Ogfod2 T C 5: 124,250,910 (GRCm39) probably null Het
Or8b48 C T 9: 38,492,809 (GRCm39) P79S probably damaging Het
Or8g20 A T 9: 39,396,333 (GRCm39) I72N probably damaging Het
Pard6g T C 18: 80,160,985 (GRCm39) L366P probably damaging Het
Pdlim4 A T 11: 53,946,759 (GRCm39) L117H probably damaging Het
Pkd1l1 G A 11: 8,852,467 (GRCm39) A672V probably benign Het
Pomt2 A G 12: 87,164,703 (GRCm39) probably benign Het
Prpf4 T A 4: 62,333,633 (GRCm39) probably benign Het
Rad17 C T 13: 100,770,370 (GRCm39) probably null Het
Ryr3 T A 2: 112,475,622 (GRCm39) I4499F probably damaging Het
Sav1 A G 12: 70,033,550 (GRCm39) probably benign Het
Scube1 A T 15: 83,491,591 (GRCm39) F887I probably damaging Het
Slc5a6 T C 5: 31,195,179 (GRCm39) S473G probably benign Het
Taf1b T C 12: 24,594,270 (GRCm39) S268P possibly damaging Het
Tmem135 A T 7: 88,814,331 (GRCm39) probably null Het
Vmn2r104 A T 17: 20,263,118 (GRCm39) N114K probably benign Het
Ypel5 A T 17: 73,155,591 (GRCm39) Y53F probably benign Het
Zzef1 T C 11: 72,757,423 (GRCm39) probably benign Het
Other mutations in Zfp438
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01907:Zfp438 APN 18 5,213,815 (GRCm39) missense probably damaging 1.00
IGL01967:Zfp438 APN 18 5,214,049 (GRCm39) missense probably benign 0.00
IGL02003:Zfp438 APN 18 5,214,503 (GRCm39) missense probably benign 0.15
IGL02439:Zfp438 APN 18 5,213,216 (GRCm39) missense probably damaging 1.00
IGL02744:Zfp438 APN 18 5,214,760 (GRCm39) missense probably benign 0.03
IGL02836:Zfp438 APN 18 5,245,427 (GRCm39) utr 5 prime probably benign
R0308:Zfp438 UTSW 18 5,213,638 (GRCm39) missense probably benign 0.00
R0437:Zfp438 UTSW 18 5,214,910 (GRCm39) missense probably damaging 0.97
R1540:Zfp438 UTSW 18 5,210,740 (GRCm39) missense probably benign 0.04
R1594:Zfp438 UTSW 18 5,213,515 (GRCm39) missense possibly damaging 0.94
R1804:Zfp438 UTSW 18 5,213,689 (GRCm39) missense probably damaging 1.00
R2057:Zfp438 UTSW 18 5,214,085 (GRCm39) missense probably benign 0.03
R2256:Zfp438 UTSW 18 5,213,508 (GRCm39) missense probably damaging 0.99
R4549:Zfp438 UTSW 18 5,214,073 (GRCm39) missense probably benign 0.01
R4747:Zfp438 UTSW 18 5,214,403 (GRCm39) missense probably benign 0.00
R4858:Zfp438 UTSW 18 5,213,154 (GRCm39) missense probably benign 0.01
R4887:Zfp438 UTSW 18 5,213,776 (GRCm39) missense possibly damaging 0.55
R5543:Zfp438 UTSW 18 5,213,761 (GRCm39) missense probably damaging 1.00
R5646:Zfp438 UTSW 18 5,214,526 (GRCm39) missense probably benign 0.36
R6022:Zfp438 UTSW 18 5,213,419 (GRCm39) missense probably damaging 1.00
R6058:Zfp438 UTSW 18 5,213,209 (GRCm39) missense probably damaging 1.00
R6460:Zfp438 UTSW 18 5,213,603 (GRCm39) missense probably damaging 1.00
R6703:Zfp438 UTSW 18 5,214,044 (GRCm39) missense probably benign 0.05
R6766:Zfp438 UTSW 18 5,213,780 (GRCm39) missense probably benign 0.07
R7252:Zfp438 UTSW 18 5,214,874 (GRCm39) nonsense probably null
R7283:Zfp438 UTSW 18 5,214,712 (GRCm39) missense probably damaging 1.00
R7429:Zfp438 UTSW 18 5,214,139 (GRCm39) missense probably benign 0.01
R7769:Zfp438 UTSW 18 5,213,377 (GRCm39) missense possibly damaging 0.93
R8139:Zfp438 UTSW 18 5,214,013 (GRCm39) missense probably benign 0.01
R8291:Zfp438 UTSW 18 5,211,010 (GRCm39) nonsense probably null
R8802:Zfp438 UTSW 18 5,213,417 (GRCm39) missense possibly damaging 0.88
R8819:Zfp438 UTSW 18 5,213,383 (GRCm39) missense possibly damaging 0.91
R8922:Zfp438 UTSW 18 5,213,422 (GRCm39) missense possibly damaging 0.65
R9224:Zfp438 UTSW 18 5,210,788 (GRCm39) missense probably damaging 1.00
R9416:Zfp438 UTSW 18 5,214,054 (GRCm39) missense probably benign 0.01
R9442:Zfp438 UTSW 18 5,214,379 (GRCm39) missense probably benign 0.00
R9529:Zfp438 UTSW 18 5,213,501 (GRCm39) missense possibly damaging 0.61
Posted On 2015-04-16