Incidental Mutation 'IGL02309:Usf3'
ID 287746
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Usf3
Ensembl Gene ENSMUSG00000068284
Gene Name upstream transcription factor family member 3
Synonyms LOC207806, 5530400K22Rik, Gm608, LOC385650
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.271) question?
Stock # IGL02309
Quality Score
Status
Chromosome 16
Chromosomal Location 43993609-44047828 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 44021026 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 11 (T11M)
Ref Sequence ENSEMBL: ENSMUSP00000128627 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088356] [ENSMUST00000119746] [ENSMUST00000169582]
AlphaFold B2RUQ2
Predicted Effect probably benign
Transcript: ENSMUST00000088356
AA Change: T11M

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000085694
Gene: ENSMUSG00000068284
AA Change: T11M

DomainStartEndE-ValueType
HLH 24 75 4.26e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000119746
AA Change: T11M

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000112620
Gene: ENSMUSG00000068284
AA Change: T11M

DomainStartEndE-ValueType
HLH 24 75 4.26e-9 SMART
low complexity region 151 162 N/A INTRINSIC
low complexity region 246 262 N/A INTRINSIC
low complexity region 367 379 N/A INTRINSIC
low complexity region 399 413 N/A INTRINSIC
low complexity region 571 587 N/A INTRINSIC
low complexity region 765 782 N/A INTRINSIC
low complexity region 950 969 N/A INTRINSIC
low complexity region 1084 1100 N/A INTRINSIC
low complexity region 1370 1382 N/A INTRINSIC
low complexity region 1419 1437 N/A INTRINSIC
low complexity region 1527 1555 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141015
Predicted Effect probably benign
Transcript: ENSMUST00000169582
AA Change: T11M

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000128627
Gene: ENSMUSG00000068284
AA Change: T11M

DomainStartEndE-ValueType
HLH 24 75 4.26e-9 SMART
low complexity region 151 162 N/A INTRINSIC
low complexity region 246 262 N/A INTRINSIC
low complexity region 367 379 N/A INTRINSIC
low complexity region 399 413 N/A INTRINSIC
low complexity region 571 587 N/A INTRINSIC
low complexity region 765 782 N/A INTRINSIC
low complexity region 950 969 N/A INTRINSIC
low complexity region 1084 1100 N/A INTRINSIC
low complexity region 1370 1382 N/A INTRINSIC
low complexity region 1419 1437 N/A INTRINSIC
low complexity region 1527 1555 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg4 A G 9: 44,193,125 (GRCm39) F111S probably benign Het
Afg1l C A 10: 42,330,374 (GRCm39) V98F possibly damaging Het
Agk T A 6: 40,353,210 (GRCm39) D191E possibly damaging Het
Akap5 A G 12: 76,375,629 (GRCm39) K354E possibly damaging Het
Aplp2 A T 9: 31,078,979 (GRCm39) M323K possibly damaging Het
Arhgap23 T C 11: 97,356,827 (GRCm39) probably benign Het
Asl A G 5: 130,048,622 (GRCm39) Y30H probably damaging Het
Asxl3 T A 18: 22,655,510 (GRCm39) H1173Q probably benign Het
Celsr2 C T 3: 108,303,327 (GRCm39) R2472H probably damaging Het
Clip1 T A 5: 123,755,763 (GRCm39) H950L probably damaging Het
Cx3cl1 A T 8: 95,506,660 (GRCm39) T222S probably benign Het
Cyp4a14 T A 4: 115,348,829 (GRCm39) N273Y probably damaging Het
Ddx52 T A 11: 83,839,304 (GRCm39) S214T probably damaging Het
Dennd2d T A 3: 106,402,284 (GRCm39) M318K probably benign Het
Dock3 A T 9: 106,790,351 (GRCm39) D1E probably damaging Het
Farp1 C T 14: 121,480,928 (GRCm39) T443I probably benign Het
Gm2381 C T 7: 42,472,033 (GRCm39) probably benign Het
Gpr87 T A 3: 59,086,975 (GRCm39) I178F possibly damaging Het
Grin2b C T 6: 135,713,470 (GRCm39) E804K probably damaging Het
Gtf2h1 T C 7: 46,465,812 (GRCm39) L421P probably damaging Het
Haghl T G 17: 26,003,638 (GRCm39) H56P probably damaging Het
Heatr3 T C 8: 88,893,700 (GRCm39) L489P probably damaging Het
Ighv6-6 A T 12: 114,398,534 (GRCm39) H77Q probably benign Het
Kdm2b A G 5: 123,085,883 (GRCm39) S243P probably damaging Het
Lamc3 T C 2: 31,804,616 (GRCm39) probably benign Het
Lgr4 T C 2: 109,842,880 (GRCm39) probably benign Het
Lhx3 T C 2: 26,091,385 (GRCm39) Q308R probably benign Het
Lonp2 G A 8: 87,361,491 (GRCm39) E223K probably damaging Het
Lta4h T C 10: 93,310,352 (GRCm39) F407L probably damaging Het
Mndal C T 1: 173,702,021 (GRCm39) G94R probably damaging Het
Nrxn3 A G 12: 89,943,175 (GRCm39) N101S probably damaging Het
Or14c41 T C 7: 86,234,705 (GRCm39) V74A possibly damaging Het
Or51af1 A T 7: 103,141,206 (GRCm39) I293K probably damaging Het
Or8b48 C T 9: 38,492,809 (GRCm39) P79S probably damaging Het
Or8b48 A G 9: 38,492,729 (GRCm39) N52S probably damaging Het
Or8d23 A G 9: 38,842,348 (GRCm39) N294D probably damaging Het
Pknox1 T G 17: 31,809,683 (GRCm39) F96V probably benign Het
Psg25 T G 7: 18,260,349 (GRCm39) Q183P probably damaging Het
Ptgs2 A G 1: 149,981,307 (GRCm39) Y530C probably damaging Het
Sema3e T A 5: 14,274,404 (GRCm39) D218E probably damaging Het
Shank1 G A 7: 43,962,266 (GRCm39) G46R unknown Het
Sidt1 T C 16: 44,075,343 (GRCm39) I672V probably benign Het
Skic3 A G 13: 76,275,166 (GRCm39) T238A possibly damaging Het
Slco1b2 T A 6: 141,618,007 (GRCm39) S486T probably damaging Het
Smchd1 T C 17: 71,750,898 (GRCm39) H340R probably benign Het
Smoc2 C A 17: 14,595,789 (GRCm39) probably benign Het
Snapc1 A G 12: 74,014,801 (GRCm39) Y102C probably damaging Het
Spo11 A G 2: 172,821,744 (GRCm39) R20G probably damaging Het
Tlr1 A T 5: 65,083,290 (GRCm39) L429* probably null Het
Tmem229b-ps T C 10: 53,351,466 (GRCm39) noncoding transcript Het
Trim12c T A 7: 103,994,163 (GRCm39) E230D possibly damaging Het
Ttc17 G T 2: 94,173,006 (GRCm39) N796K probably benign Het
Ttn A G 2: 76,709,443 (GRCm39) probably benign Het
Ublcp1 A T 11: 44,349,155 (GRCm39) probably benign Het
Vmn2r115 T A 17: 23,564,113 (GRCm39) M95K probably benign Het
Wapl A G 14: 34,466,820 (GRCm39) T1160A probably damaging Het
Other mutations in Usf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01361:Usf3 APN 16 44,033,000 (GRCm39) splice site probably null
IGL01971:Usf3 APN 16 44,037,809 (GRCm39) splice site probably null
IGL01982:Usf3 APN 16 44,039,180 (GRCm39) missense possibly damaging 0.89
IGL02124:Usf3 APN 16 44,040,019 (GRCm39) missense possibly damaging 0.82
IGL02454:Usf3 APN 16 44,037,545 (GRCm39) missense probably damaging 1.00
IGL02526:Usf3 APN 16 44,040,674 (GRCm39) missense possibly damaging 0.89
IGL02671:Usf3 APN 16 44,042,144 (GRCm39) missense probably damaging 1.00
IGL02800:Usf3 APN 16 44,039,459 (GRCm39) missense probably benign 0.00
IGL02899:Usf3 APN 16 44,041,589 (GRCm39) missense probably damaging 1.00
IGL03223:Usf3 APN 16 44,036,813 (GRCm39) missense probably damaging 1.00
I1329:Usf3 UTSW 16 44,040,893 (GRCm39) missense probably damaging 1.00
R0208:Usf3 UTSW 16 44,037,269 (GRCm39) missense probably damaging 0.98
R0900:Usf3 UTSW 16 44,036,321 (GRCm39) missense probably benign
R1160:Usf3 UTSW 16 44,038,910 (GRCm39) missense probably damaging 1.00
R1417:Usf3 UTSW 16 44,037,812 (GRCm39) missense probably benign 0.00
R1512:Usf3 UTSW 16 44,041,561 (GRCm39) missense probably damaging 1.00
R1603:Usf3 UTSW 16 44,038,535 (GRCm39) missense probably benign
R1702:Usf3 UTSW 16 44,039,995 (GRCm39) nonsense probably null
R1774:Usf3 UTSW 16 44,036,033 (GRCm39) missense probably damaging 1.00
R2344:Usf3 UTSW 16 44,036,414 (GRCm39) missense probably benign
R2400:Usf3 UTSW 16 44,036,110 (GRCm39) missense probably benign 0.04
R2484:Usf3 UTSW 16 44,041,045 (GRCm39) missense probably damaging 0.99
R2570:Usf3 UTSW 16 44,036,744 (GRCm39) missense probably benign 0.00
R3730:Usf3 UTSW 16 44,038,938 (GRCm39) missense probably benign 0.00
R4024:Usf3 UTSW 16 44,036,528 (GRCm39) missense possibly damaging 0.76
R4451:Usf3 UTSW 16 44,038,251 (GRCm39) missense possibly damaging 0.76
R4883:Usf3 UTSW 16 44,039,942 (GRCm39) missense probably damaging 1.00
R4895:Usf3 UTSW 16 44,041,459 (GRCm39) missense possibly damaging 0.93
R4924:Usf3 UTSW 16 44,037,718 (GRCm39) missense probably benign
R5020:Usf3 UTSW 16 44,035,889 (GRCm39) missense probably damaging 1.00
R5034:Usf3 UTSW 16 44,036,762 (GRCm39) missense probably damaging 1.00
R5053:Usf3 UTSW 16 44,037,550 (GRCm39) missense probably benign 0.01
R5058:Usf3 UTSW 16 44,033,070 (GRCm39) missense probably damaging 1.00
R5164:Usf3 UTSW 16 44,038,543 (GRCm39) missense probably damaging 1.00
R5391:Usf3 UTSW 16 44,037,826 (GRCm39) missense probably benign 0.01
R5407:Usf3 UTSW 16 44,037,769 (GRCm39) missense probably benign 0.01
R5536:Usf3 UTSW 16 44,037,733 (GRCm39) missense probably benign 0.16
R5805:Usf3 UTSW 16 44,041,109 (GRCm39) missense possibly damaging 0.50
R5966:Usf3 UTSW 16 44,041,222 (GRCm39) missense probably benign 0.14
R6024:Usf3 UTSW 16 44,040,203 (GRCm39) missense probably damaging 1.00
R6122:Usf3 UTSW 16 44,037,670 (GRCm39) missense probably damaging 0.99
R6180:Usf3 UTSW 16 44,041,468 (GRCm39) missense probably damaging 1.00
R6362:Usf3 UTSW 16 44,038,940 (GRCm39) missense probably benign 0.01
R6579:Usf3 UTSW 16 44,039,197 (GRCm39) missense possibly damaging 0.54
R6874:Usf3 UTSW 16 44,040,103 (GRCm39) missense probably benign 0.00
R7226:Usf3 UTSW 16 44,040,368 (GRCm39) missense possibly damaging 0.54
R7379:Usf3 UTSW 16 44,040,939 (GRCm39) missense probably benign 0.33
R7389:Usf3 UTSW 16 44,038,304 (GRCm39) missense probably benign 0.09
R7452:Usf3 UTSW 16 44,040,397 (GRCm39) missense probably benign 0.00
R7606:Usf3 UTSW 16 44,039,306 (GRCm39) missense probably damaging 1.00
R7750:Usf3 UTSW 16 44,040,884 (GRCm39) missense probably benign 0.15
R7765:Usf3 UTSW 16 44,039,426 (GRCm39) missense probably benign 0.28
R7830:Usf3 UTSW 16 44,040,142 (GRCm39) nonsense probably null
R7895:Usf3 UTSW 16 44,036,565 (GRCm39) missense possibly damaging 0.67
R7941:Usf3 UTSW 16 44,035,924 (GRCm39) missense probably damaging 1.00
R8280:Usf3 UTSW 16 44,038,864 (GRCm39) missense probably benign 0.00
R8285:Usf3 UTSW 16 44,041,207 (GRCm39) missense probably damaging 1.00
R8421:Usf3 UTSW 16 44,037,572 (GRCm39) missense possibly damaging 0.67
R8692:Usf3 UTSW 16 44,040,103 (GRCm39) missense probably benign 0.00
R8798:Usf3 UTSW 16 44,040,536 (GRCm39) missense probably damaging 0.99
R8824:Usf3 UTSW 16 44,035,976 (GRCm39) missense probably benign 0.12
R9123:Usf3 UTSW 16 44,041,030 (GRCm39) missense probably benign
R9266:Usf3 UTSW 16 44,040,095 (GRCm39) missense probably damaging 0.98
R9335:Usf3 UTSW 16 44,041,936 (GRCm39) missense probably damaging 1.00
R9610:Usf3 UTSW 16 44,036,936 (GRCm39) missense probably benign 0.00
R9643:Usf3 UTSW 16 44,042,170 (GRCm39) missense possibly damaging 0.47
R9780:Usf3 UTSW 16 44,039,181 (GRCm39) missense possibly damaging 0.89
R9785:Usf3 UTSW 16 44,041,970 (GRCm39) missense probably benign 0.33
X0057:Usf3 UTSW 16 44,041,147 (GRCm39) missense probably benign 0.32
X0066:Usf3 UTSW 16 44,040,790 (GRCm39) missense probably benign 0.00
Z1176:Usf3 UTSW 16 44,040,794 (GRCm39) missense probably benign 0.23
Posted On 2015-04-16