Incidental Mutation 'IGL02311:Vps18'
ID |
287794 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Vps18
|
Ensembl Gene |
ENSMUSG00000034216 |
Gene Name |
VPS18 CORVET/HOPS core subunit |
Synonyms |
9930024E13Rik |
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
IGL02311
|
Quality Score |
|
Status
|
|
Chromosome |
2 |
Chromosomal Location |
119119221-119128934 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 119120732 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Cysteine to Arginine
at position 64
(C64R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000036915
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037280]
|
AlphaFold |
Q8R307 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000037280
AA Change: C64R
PolyPhen 2
Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
|
SMART Domains |
Protein: ENSMUSP00000036915 Gene: ENSMUSG00000034216 AA Change: C64R
Domain | Start | End | E-Value | Type |
Pfam:Pep3_Vps18
|
291 |
435 |
2.4e-41 |
PFAM |
low complexity region
|
486 |
500 |
N/A |
INTRINSIC |
Pfam:Clathrin
|
619 |
771 |
5.9e-11 |
PFAM |
coiled coil region
|
803 |
845 |
N/A |
INTRINSIC |
Blast:RING
|
853 |
947 |
3e-47 |
BLAST |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139367
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151500
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008] PHENOTYPE: Mice homozygous for a reporter allele exhibit preweaning lethality. Mice homozygous for a conditional allele activated in the nervous system exhibit impaired neuron migration and neurodegeneration associated with increased apoptosis and impaired autophagy and endocytosis. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1500035N22Rik |
C |
A |
5: 25,202,705 (GRCm39) |
|
probably benign |
Het |
Adam21 |
T |
G |
12: 81,607,666 (GRCm39) |
D32A |
probably benign |
Het |
Asns |
A |
G |
6: 7,676,233 (GRCm39) |
|
probably null |
Het |
Bin3 |
A |
T |
14: 70,361,666 (GRCm39) |
M45L |
probably benign |
Het |
Cfap44 |
A |
T |
16: 44,225,134 (GRCm39) |
|
probably benign |
Het |
Cmya5 |
T |
C |
13: 93,227,163 (GRCm39) |
T2642A |
probably benign |
Het |
Dbndd2 |
T |
C |
2: 164,330,622 (GRCm39) |
S92P |
possibly damaging |
Het |
Dclre1b |
A |
C |
3: 103,715,409 (GRCm39) |
F30V |
probably damaging |
Het |
Dock6 |
T |
C |
9: 21,755,624 (GRCm39) |
D200G |
probably damaging |
Het |
Epb41l4b |
C |
A |
4: 57,076,456 (GRCm39) |
R335L |
probably damaging |
Het |
Fscn1 |
T |
C |
5: 142,957,765 (GRCm39) |
V304A |
probably benign |
Het |
Gm7008 |
G |
A |
12: 40,273,385 (GRCm39) |
|
probably benign |
Het |
Gm8237 |
A |
G |
14: 5,864,425 (GRCm38) |
|
probably null |
Het |
Ifih1 |
T |
C |
2: 62,440,847 (GRCm39) |
T440A |
probably damaging |
Het |
Mepe |
C |
T |
5: 104,485,571 (GRCm39) |
S237F |
probably damaging |
Het |
Nr4a2 |
T |
C |
2: 57,001,743 (GRCm39) |
I174V |
probably benign |
Het |
Or2ag2 |
A |
G |
7: 106,485,101 (GRCm39) |
Y308H |
probably benign |
Het |
Or8c11 |
C |
T |
9: 38,289,194 (GRCm39) |
Q6* |
probably null |
Het |
Orc1 |
G |
T |
4: 108,457,171 (GRCm39) |
V404L |
probably benign |
Het |
Pcsk5 |
G |
T |
19: 17,410,784 (GRCm39) |
Y1869* |
probably null |
Het |
Phf21b |
A |
G |
15: 84,678,095 (GRCm39) |
|
probably null |
Het |
Pigg |
A |
G |
5: 108,484,246 (GRCm39) |
T631A |
probably benign |
Het |
Plxnb1 |
A |
G |
9: 108,930,190 (GRCm39) |
N349D |
probably benign |
Het |
Scaf11 |
T |
C |
15: 96,316,637 (GRCm39) |
S976G |
probably benign |
Het |
Scn8a |
G |
T |
15: 100,911,164 (GRCm39) |
M861I |
probably damaging |
Het |
Stau1 |
T |
C |
2: 166,792,239 (GRCm39) |
N433S |
probably damaging |
Het |
Synrg |
A |
G |
11: 83,910,630 (GRCm39) |
K854R |
probably benign |
Het |
Tbata |
T |
A |
10: 61,015,234 (GRCm39) |
C150* |
probably null |
Het |
Tcn2 |
G |
A |
11: 3,867,692 (GRCm39) |
P417S |
probably damaging |
Het |
Tlr1 |
A |
T |
5: 65,083,290 (GRCm39) |
L429* |
probably null |
Het |
Tpr |
G |
T |
1: 150,274,404 (GRCm39) |
D104Y |
probably damaging |
Het |
Ubash3b |
T |
C |
9: 40,958,333 (GRCm39) |
T16A |
probably benign |
Het |
Uso1 |
T |
A |
5: 92,335,635 (GRCm39) |
S548T |
probably benign |
Het |
Vps13b |
T |
A |
15: 35,709,660 (GRCm39) |
V1869E |
probably benign |
Het |
Zic2 |
C |
A |
14: 122,713,606 (GRCm39) |
N173K |
probably damaging |
Het |
|
Other mutations in Vps18 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01627:Vps18
|
APN |
2 |
119,127,672 (GRCm39) |
missense |
probably benign |
0.03 |
IGL02332:Vps18
|
APN |
2 |
119,124,291 (GRCm39) |
missense |
probably benign |
0.04 |
IGL03089:Vps18
|
APN |
2 |
119,123,658 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03114:Vps18
|
APN |
2 |
119,124,132 (GRCm39) |
missense |
possibly damaging |
0.55 |
IGL03334:Vps18
|
APN |
2 |
119,127,963 (GRCm39) |
missense |
probably damaging |
1.00 |
F5770:Vps18
|
UTSW |
2 |
119,127,709 (GRCm39) |
missense |
probably benign |
0.22 |
R0311:Vps18
|
UTSW |
2 |
119,127,846 (GRCm39) |
missense |
probably benign |
0.05 |
R0346:Vps18
|
UTSW |
2 |
119,127,645 (GRCm39) |
missense |
probably damaging |
1.00 |
R0373:Vps18
|
UTSW |
2 |
119,124,386 (GRCm39) |
missense |
probably damaging |
0.99 |
R0637:Vps18
|
UTSW |
2 |
119,124,386 (GRCm39) |
missense |
probably damaging |
0.99 |
R1493:Vps18
|
UTSW |
2 |
119,127,613 (GRCm39) |
missense |
probably damaging |
1.00 |
R1703:Vps18
|
UTSW |
2 |
119,119,538 (GRCm39) |
missense |
probably benign |
0.03 |
R1734:Vps18
|
UTSW |
2 |
119,124,423 (GRCm39) |
missense |
probably benign |
0.01 |
R4297:Vps18
|
UTSW |
2 |
119,127,812 (GRCm39) |
nonsense |
probably null |
|
R4633:Vps18
|
UTSW |
2 |
119,123,757 (GRCm39) |
missense |
probably damaging |
1.00 |
R4729:Vps18
|
UTSW |
2 |
119,124,272 (GRCm39) |
missense |
probably damaging |
1.00 |
R5034:Vps18
|
UTSW |
2 |
119,123,787 (GRCm39) |
missense |
probably benign |
0.00 |
R5162:Vps18
|
UTSW |
2 |
119,123,423 (GRCm39) |
missense |
probably benign |
0.19 |
R5320:Vps18
|
UTSW |
2 |
119,127,858 (GRCm39) |
nonsense |
probably null |
|
R5857:Vps18
|
UTSW |
2 |
119,128,014 (GRCm39) |
missense |
probably damaging |
1.00 |
R6105:Vps18
|
UTSW |
2 |
119,119,543 (GRCm39) |
missense |
probably damaging |
1.00 |
R6150:Vps18
|
UTSW |
2 |
119,128,073 (GRCm39) |
nonsense |
probably null |
|
R7934:Vps18
|
UTSW |
2 |
119,124,122 (GRCm39) |
missense |
probably benign |
0.11 |
R8018:Vps18
|
UTSW |
2 |
119,124,492 (GRCm39) |
missense |
probably damaging |
1.00 |
R8147:Vps18
|
UTSW |
2 |
119,123,237 (GRCm39) |
missense |
probably benign |
0.19 |
R8401:Vps18
|
UTSW |
2 |
119,127,973 (GRCm39) |
missense |
probably damaging |
0.96 |
R8525:Vps18
|
UTSW |
2 |
119,120,711 (GRCm39) |
missense |
possibly damaging |
0.68 |
R9044:Vps18
|
UTSW |
2 |
119,128,034 (GRCm39) |
missense |
probably damaging |
1.00 |
R9719:Vps18
|
UTSW |
2 |
119,127,553 (GRCm39) |
missense |
probably damaging |
1.00 |
RF002:Vps18
|
UTSW |
2 |
119,127,871 (GRCm39) |
missense |
probably damaging |
1.00 |
V7583:Vps18
|
UTSW |
2 |
119,127,709 (GRCm39) |
missense |
probably benign |
0.22 |
|
Posted On |
2015-04-16 |