Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02312:Bicra'

287827

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Bicra

Ensembl Gene

ENSMUSG00000070808

Gene Name

BRD4 interacting chromatin remodeling complex associated protein

Synonyms

Gltscr1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.176) question?

Stock #

IGL02312

Quality Score

Status

Chromosome

Chromosomal Location

15704597-15781846 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 15727066 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 30 (D30G)

Ref Sequence

ENSEMBL: ENSMUSP00000148012 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094821] [ENSMUST00000210781]

AlphaFold

F8VPZ9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000094821
AA Change: D30G

PolyPhen 2 Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000092416
Gene: ENSMUSG00000070808
AA Change: D30G

Domain	Start	End	E-Value	Type
low complexity region	86	96	N/A	INTRINSIC
low complexity region	140	155	N/A	INTRINSIC
internal_repeat_1	156	298	1.03e-6	PROSPERO
low complexity region	308	323	N/A	INTRINSIC
low complexity region	427	443	N/A	INTRINSIC
internal_repeat_1	479	614	1.03e-6	PROSPERO
low complexity region	619	638	N/A	INTRINSIC
low complexity region	642	676	N/A	INTRINSIC
low complexity region	719	732	N/A	INTRINSIC
low complexity region	756	782	N/A	INTRINSIC
low complexity region	790	819	N/A	INTRINSIC
low complexity region	827	843	N/A	INTRINSIC
low complexity region	852	906	N/A	INTRINSIC
low complexity region	940	950	N/A	INTRINSIC
low complexity region	987	1006	N/A	INTRINSIC
Pfam:GLTSCR1	1094	1202	4.6e-43	PFAM
low complexity region	1232	1251	N/A	INTRINSIC
low complexity region	1275	1294	N/A	INTRINSIC
low complexity region	1349	1371	N/A	INTRINSIC
low complexity region	1460	1473	N/A	INTRINSIC
low complexity region	1535	1555	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210713

Predicted Effect

possibly damaging
Transcript: ENSMUST00000210781
AA Change: D30G

PolyPhen 2 Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts19	T	A	18: 59,060,369 (GRCm39)	V454E	probably damaging	Het
Atp7b	G	T	8: 22,484,786 (GRCm39)	Q1424K	probably damaging	Het
Cdhr2	A	G	13: 54,865,701 (GRCm39)	D233G	probably null	Het
Clint1	C	T	11: 45,784,883 (GRCm39)	T294M	probably damaging	Het
Cntnap5c	C	T	17: 58,445,694 (GRCm39)	T578I	probably benign	Het
Col12a1	G	T	9: 79,588,797 (GRCm39)	T1106N	probably damaging	Het
Csta3	A	G	16: 36,030,847 (GRCm39)		probably benign	Het
Dnah10	A	G	5: 124,896,430 (GRCm39)	Y3598C	probably damaging	Het
Dnaja3	A	G	16: 4,512,300 (GRCm39)	T235A	probably benign	Het
Eif2s1	T	C	12: 78,926,790 (GRCm39)	I180T	probably damaging	Het
Ergic1	C	A	17: 26,848,601 (GRCm39)	P108Q	probably damaging	Het
Fat2	T	A	11: 55,161,085 (GRCm39)	D3215V	probably damaging	Het
Galnt17	A	T	5: 131,335,371 (GRCm39)	I23N	probably benign	Het
Gpr20	C	T	15: 73,568,275 (GRCm39)	R38Q	probably benign	Het
Grin2b	T	C	6: 135,716,088 (GRCm39)	D743G	probably damaging	Het
H2-T5	T	C	17: 36,476,299 (GRCm39)	I350V	probably benign	Het
Hmbs	A	G	9: 44,252,510 (GRCm39)		probably null	Het
Hunk	T	C	16: 90,272,829 (GRCm39)	Y302H	probably damaging	Het
Mybph	A	T	1: 134,125,188 (GRCm39)	I239F	probably damaging	Het
Ncoa3	G	A	2: 165,899,120 (GRCm39)	A821T	probably benign	Het
Nf1	A	G	11: 79,335,474 (GRCm39)	I979V	possibly damaging	Het
Or5w14	T	C	2: 87,541,353 (GRCm39)	E299G	probably benign	Het
Or7h8	A	T	9: 20,124,377 (GRCm39)	H244L	probably damaging	Het
Pdilt	G	A	7: 119,118,890 (GRCm39)	T53M	probably benign	Het
Pdlim1	T	C	19: 40,211,505 (GRCm39)	T263A	probably benign	Het
Pik3cg	A	T	12: 32,244,820 (GRCm39)	M878K	possibly damaging	Het
Plod1	T	C	4: 148,010,614 (GRCm39)	K279R	probably benign	Het
Plxna4	T	C	6: 32,142,052 (GRCm39)	T1602A	possibly damaging	Het
Rb1cc1	T	A	1: 6,335,847 (GRCm39)		probably null	Het
Rnls	G	A	19: 33,145,783 (GRCm39)	T112I	probably benign	Het
Ropn1	G	A	16: 34,497,647 (GRCm39)	V180I	probably benign	Het
Rptor	T	C	11: 119,737,741 (GRCm39)	Y605H	possibly damaging	Het
Sidt2	T	C	9: 45,858,299 (GRCm39)	Y80C	probably benign	Het
Slit1	A	T	19: 41,590,119 (GRCm39)	V1389E	possibly damaging	Het
Spz1	G	A	13: 92,712,393 (GRCm39)	P28S	probably benign	Het
Sult1c2	T	A	17: 54,269,458 (GRCm39)	M257L	probably benign	Het
Tent2	C	T	13: 93,312,041 (GRCm39)	V220I	probably benign	Het
Tm2d3	T	C	7: 65,348,917 (GRCm39)		probably null	Het
Uqcr10	T	C	11: 4,654,153 (GRCm39)		probably null	Het

Other mutations in Bicra

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00909:Bicra	APN	7	15,730,502 (GRCm39)	missense	possibly damaging	0.70
IGL01521:Bicra	APN	7	15,723,113 (GRCm39)	missense	probably benign	0.18
IGL01690:Bicra	APN	7	15,721,678 (GRCm39)	missense	probably benign	0.09
IGL01721:Bicra	APN	7	15,722,624 (GRCm39)	missense	probably benign
IGL01994:Bicra	APN	7	15,706,741 (GRCm39)	missense	possibly damaging	0.46
IGL02084:Bicra	APN	7	15,721,663 (GRCm39)	missense	probably benign	0.09
IGL02686:Bicra	APN	7	15,721,840 (GRCm39)	missense	probably benign	0.02
IGL02727:Bicra	APN	7	15,713,390 (GRCm39)	missense	possibly damaging	0.95
IGL03031:Bicra	APN	7	15,709,726 (GRCm39)	missense	probably benign	0.16
R0003:Bicra	UTSW	7	15,705,812 (GRCm39)	missense	probably benign
R0025:Bicra	UTSW	7	15,721,436 (GRCm39)	missense	possibly damaging	0.53
R0241:Bicra	UTSW	7	15,709,070 (GRCm39)	missense	probably damaging	1.00
R0241:Bicra	UTSW	7	15,709,070 (GRCm39)	missense	probably damaging	1.00
R0417:Bicra	UTSW	7	15,706,247 (GRCm39)	missense	probably damaging	1.00
R0437:Bicra	UTSW	7	15,722,687 (GRCm39)	missense	possibly damaging	0.73
R0547:Bicra	UTSW	7	15,706,173 (GRCm39)	missense	probably damaging	1.00
R0688:Bicra	UTSW	7	15,723,247 (GRCm39)	missense	probably damaging	1.00
R0855:Bicra	UTSW	7	15,705,929 (GRCm39)	missense	probably damaging	1.00
R1448:Bicra	UTSW	7	15,722,284 (GRCm39)	missense	possibly damaging	0.86
R1637:Bicra	UTSW	7	15,706,614 (GRCm39)	missense	probably benign	0.19
R1899:Bicra	UTSW	7	15,721,676 (GRCm39)	missense	possibly damaging	0.53
R2035:Bicra	UTSW	7	15,730,338 (GRCm39)	missense	possibly damaging	0.53
R2247:Bicra	UTSW	7	15,723,159 (GRCm39)	missense	probably benign	0.33
R2471:Bicra	UTSW	7	15,706,257 (GRCm39)	missense	probably benign	0.04
R2484:Bicra	UTSW	7	15,722,605 (GRCm39)	missense	possibly damaging	0.96
R3437:Bicra	UTSW	7	15,723,223 (GRCm39)	missense	possibly damaging	0.85
R3551:Bicra	UTSW	7	15,713,658 (GRCm39)	missense	probably benign	0.33
R4816:Bicra	UTSW	7	15,722,831 (GRCm39)	missense	possibly damaging	0.53
R4901:Bicra	UTSW	7	15,721,526 (GRCm39)	missense	possibly damaging	0.53
R5035:Bicra	UTSW	7	15,713,349 (GRCm39)	missense	possibly damaging	0.90
R5078:Bicra	UTSW	7	15,709,382 (GRCm39)	missense	probably damaging	1.00
R5094:Bicra	UTSW	7	15,709,296 (GRCm39)	missense	probably damaging	1.00
R5195:Bicra	UTSW	7	15,713,878 (GRCm39)	missense	possibly damaging	0.93
R5496:Bicra	UTSW	7	15,721,766 (GRCm39)	missense	probably benign	0.33
R5780:Bicra	UTSW	7	15,713,679 (GRCm39)	missense	possibly damaging	0.96
R6541:Bicra	UTSW	7	15,713,054 (GRCm39)	missense	probably benign	0.00
R6560:Bicra	UTSW	7	15,723,119 (GRCm39)	missense	possibly damaging	0.53
R6575:Bicra	UTSW	7	15,713,056 (GRCm39)	missense	probably benign	0.25
R6854:Bicra	UTSW	7	15,722,687 (GRCm39)	missense	probably benign	0.18
R6967:Bicra	UTSW	7	15,706,130 (GRCm39)	missense	probably damaging	0.97
R7283:Bicra	UTSW	7	15,706,425 (GRCm39)	missense	probably damaging	1.00
R7454:Bicra	UTSW	7	15,706,059 (GRCm39)	missense	probably benign	0.30
R7462:Bicra	UTSW	7	15,713,060 (GRCm39)	missense	possibly damaging	0.84
R7488:Bicra	UTSW	7	15,723,367 (GRCm39)	critical splice acceptor site	probably null
R7506:Bicra	UTSW	7	15,722,138 (GRCm39)	missense	possibly damaging	0.96
R7534:Bicra	UTSW	7	15,705,860 (GRCm39)	missense	probably damaging	0.98
R7915:Bicra	UTSW	7	15,722,447 (GRCm39)	missense	probably benign
R8063:Bicra	UTSW	7	15,712,969 (GRCm39)	missense	probably benign
R8147:Bicra	UTSW	7	15,722,395 (GRCm39)	missense	possibly damaging	0.93
R8699:Bicra	UTSW	7	15,723,113 (GRCm39)	missense	probably benign	0.18
R8784:Bicra	UTSW	7	15,705,875 (GRCm39)	missense	probably damaging	1.00
R8859:Bicra	UTSW	7	15,721,737 (GRCm39)	missense	possibly damaging	0.73
R8971:Bicra	UTSW	7	15,721,481 (GRCm39)	missense	probably benign	0.08
R9487:Bicra	UTSW	7	15,705,717 (GRCm39)	missense	probably damaging	0.99
R9614:Bicra	UTSW	7	15,705,880 (GRCm39)	missense	probably damaging	1.00
R9721:Bicra	UTSW	7	15,713,101 (GRCm39)	missense	probably damaging	1.00
R9777:Bicra	UTSW	7	15,705,987 (GRCm39)	missense	probably benign	0.09
X0064:Bicra	UTSW	7	15,709,700 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16