Incidental Mutation 'IGL02313:Zfp974'
ID 287871
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp974
Ensembl Gene ENSMUSG00000070709
Gene Name zinc finger protein 974
Synonyms 1700049G17Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL02313
Quality Score
Status
Chromosome 7
Chromosomal Location 27606817-27628885 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 27611678 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 16 (T16A)
Ref Sequence ENSEMBL: ENSMUSP00000096238 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098639] [ENSMUST00000129341]
AlphaFold Q3UVF6
Predicted Effect possibly damaging
Transcript: ENSMUST00000098639
AA Change: T16A

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000096238
Gene: ENSMUSG00000070709
AA Change: T16A

DomainStartEndE-ValueType
ZnF_C2H2 99 121 8.81e-2 SMART
ZnF_C2H2 127 149 1.82e-3 SMART
ZnF_C2H2 155 177 3.11e-2 SMART
ZnF_C2H2 201 223 2.15e-5 SMART
ZnF_C2H2 229 251 1.18e-2 SMART
ZnF_C2H2 257 279 1.47e-3 SMART
ZnF_C2H2 285 307 1.79e-2 SMART
ZnF_C2H2 313 335 2.24e-3 SMART
ZnF_C2H2 341 363 9.73e-4 SMART
ZnF_C2H2 369 391 7.26e-3 SMART
ZnF_C2H2 397 419 6.42e-4 SMART
ZnF_C2H2 425 447 3.63e-3 SMART
ZnF_C2H2 453 475 1.28e-3 SMART
ZnF_C2H2 481 503 1.26e-2 SMART
ZnF_C2H2 509 531 1.38e-3 SMART
ZnF_C2H2 537 559 3.83e-2 SMART
ZnF_C2H2 565 587 1.95e-3 SMART
ZnF_C2H2 593 615 4.61e-5 SMART
ZnF_C2H2 621 643 1.95e-3 SMART
ZnF_C2H2 649 671 1.03e-2 SMART
ZnF_C2H2 677 699 5.5e-3 SMART
ZnF_C2H2 705 727 2.37e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129341
AA Change: T90A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000115940
Gene: ENSMUSG00000070709
AA Change: T90A

DomainStartEndE-ValueType
KRAB 14 75 7.5e-37 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd13c T A 3: 157,653,571 (GRCm39) N136K probably damaging Het
Aph1b A T 9: 66,697,955 (GRCm39) probably benign Het
Atf7ip A G 6: 136,583,718 (GRCm39) K1250E probably damaging Het
Atp8b2 T C 3: 89,857,160 (GRCm39) N400S probably damaging Het
Brca2 C A 5: 150,462,126 (GRCm39) S630Y probably damaging Het
Chd6 T A 2: 160,807,595 (GRCm39) E1873V probably damaging Het
Chrna10 T C 7: 101,761,236 (GRCm39) probably benign Het
Col6a3 A G 1: 90,739,328 (GRCm39) L907P probably damaging Het
Cxcr6 A G 9: 123,639,770 (GRCm39) N264S probably damaging Het
Cyria A G 12: 12,414,752 (GRCm39) T248A possibly damaging Het
Dgkg A G 16: 22,388,980 (GRCm39) probably benign Het
Dpysl2 T G 14: 67,061,839 (GRCm39) M256L probably benign Het
Dsp G T 13: 38,380,499 (GRCm39) E1816* probably null Het
Fam13b T C 18: 34,587,709 (GRCm39) K530E probably damaging Het
Fastk T C 5: 24,648,090 (GRCm39) H242R probably damaging Het
Fbxw28 A T 9: 109,166,420 (GRCm39) H145Q possibly damaging Het
Heatr6 T C 11: 83,669,718 (GRCm39) L910P probably damaging Het
Hmcn2 A G 2: 31,343,617 (GRCm39) T4642A possibly damaging Het
Hspg2 A G 4: 137,235,700 (GRCm39) T167A probably benign Het
Igsf10 A G 3: 59,238,111 (GRCm39) L690P probably benign Het
Klhdc10 G A 6: 30,439,865 (GRCm39) probably null Het
Krt31 A G 11: 99,939,222 (GRCm39) Y232H probably damaging Het
Lsm3 A G 6: 91,493,070 (GRCm39) probably benign Het
Mfn2 T A 4: 147,969,947 (GRCm39) I375F probably damaging Het
Mfrp A T 9: 44,014,171 (GRCm39) I180F probably damaging Het
Msh3 T C 13: 92,485,820 (GRCm39) E168G possibly damaging Het
Naa16 A T 14: 79,622,108 (GRCm39) V77D probably damaging Het
Nav2 T C 7: 49,208,521 (GRCm39) S1570P probably damaging Het
Niban3 A G 8: 72,055,504 (GRCm39) R305G possibly damaging Het
Numa1 C T 7: 101,649,439 (GRCm39) R1057* probably null Het
Nup210l G A 3: 90,030,099 (GRCm39) A271T probably damaging Het
Ogdh T C 11: 6,305,400 (GRCm39) V965A probably damaging Het
Or10h28 C A 17: 33,488,639 (GRCm39) Q314K probably benign Het
Or4m1 A T 14: 50,557,473 (GRCm39) V273E probably damaging Het
Or6c219 A G 10: 129,781,772 (GRCm39) L53P probably damaging Het
Or7g21 A T 9: 19,032,671 (GRCm39) N140I probably damaging Het
Or8b51 T A 9: 38,569,362 (GRCm39) I109F probably damaging Het
Pdp2 A T 8: 105,321,531 (GRCm39) Q460L probably benign Het
Pex5l T C 3: 33,047,141 (GRCm39) T270A probably benign Het
Pkp4 C T 2: 59,140,598 (GRCm39) Q435* probably null Het
Prss32 G A 17: 24,075,096 (GRCm39) V149M probably benign Het
Riox2 C A 16: 59,309,780 (GRCm39) P378Q probably benign Het
Rita1 C T 5: 120,747,858 (GRCm39) A147T probably damaging Het
Rsph4a T A 10: 33,781,521 (GRCm39) S124T possibly damaging Het
Sdccag8 G A 1: 176,652,321 (GRCm39) R24H possibly damaging Het
Slc22a1 C A 17: 12,894,387 (GRCm39) G54* probably null Het
Slc24a5 C T 2: 124,927,567 (GRCm39) probably benign Het
Tex101 C T 7: 24,367,750 (GRCm39) V201M probably damaging Het
Tmprss7 T C 16: 45,501,956 (GRCm39) Y223C probably damaging Het
Trpc4ap T C 2: 155,492,388 (GRCm39) E382G probably damaging Het
Uggt1 A T 1: 36,223,565 (GRCm39) Y575N probably damaging Het
Vmn2r70 T C 7: 85,214,376 (GRCm39) I259V probably damaging Het
Xpo1 T A 11: 23,227,065 (GRCm39) N131K probably damaging Het
Zfp579 C T 7: 4,997,432 (GRCm39) V160M probably benign Het
Zfp697 A G 3: 98,332,766 (GRCm39) D64G probably benign Het
Other mutations in Zfp974
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00836:Zfp974 APN 7 27,610,315 (GRCm39) missense possibly damaging 0.83
IGL01805:Zfp974 APN 7 27,611,689 (GRCm39) splice site probably benign
IGL02449:Zfp974 APN 7 27,611,152 (GRCm39) missense probably benign
R0362:Zfp974 UTSW 7 27,626,819 (GRCm39) splice site probably benign
R0372:Zfp974 UTSW 7 27,620,120 (GRCm39) critical splice donor site probably null
R0379:Zfp974 UTSW 7 27,610,357 (GRCm39) missense probably damaging 0.98
R0699:Zfp974 UTSW 7 27,611,416 (GRCm39) missense possibly damaging 0.56
R0791:Zfp974 UTSW 7 27,609,510 (GRCm39) nonsense probably null
R1411:Zfp974 UTSW 7 27,610,634 (GRCm39) missense probably benign 0.00
R1567:Zfp974 UTSW 7 27,610,148 (GRCm39) missense probably damaging 0.99
R1747:Zfp974 UTSW 7 27,610,506 (GRCm39) missense possibly damaging 0.61
R1837:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R1838:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R1839:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R2311:Zfp974 UTSW 7 27,609,866 (GRCm39) missense possibly damaging 0.73
R4006:Zfp974 UTSW 7 27,611,677 (GRCm39) missense possibly damaging 0.86
R4303:Zfp974 UTSW 7 27,609,657 (GRCm39) missense possibly damaging 0.85
R4541:Zfp974 UTSW 7 27,625,829 (GRCm39) missense probably damaging 0.99
R4771:Zfp974 UTSW 7 27,625,733 (GRCm39) missense probably damaging 0.96
R4889:Zfp974 UTSW 7 27,610,244 (GRCm39) missense possibly damaging 0.86
R5332:Zfp974 UTSW 7 27,625,715 (GRCm39) missense probably benign 0.01
R5537:Zfp974 UTSW 7 27,611,671 (GRCm39) critical splice acceptor site probably benign
R5906:Zfp974 UTSW 7 27,610,230 (GRCm39) missense possibly damaging 0.72
R5908:Zfp974 UTSW 7 27,610,382 (GRCm39) missense probably benign 0.01
R6419:Zfp974 UTSW 7 27,610,940 (GRCm39) missense possibly damaging 0.72
R6654:Zfp974 UTSW 7 27,625,828 (GRCm39) missense probably damaging 1.00
R6731:Zfp974 UTSW 7 27,611,074 (GRCm39) missense possibly damaging 0.93
R7162:Zfp974 UTSW 7 27,610,944 (GRCm39) missense possibly damaging 0.71
R7316:Zfp974 UTSW 7 27,609,863 (GRCm39) missense possibly damaging 0.93
R7484:Zfp974 UTSW 7 27,611,559 (GRCm39) missense possibly damaging 0.72
R7663:Zfp974 UTSW 7 27,611,110 (GRCm39) missense possibly damaging 0.74
R7664:Zfp974 UTSW 7 27,610,137 (GRCm39) missense possibly damaging 0.86
R8052:Zfp974 UTSW 7 27,610,697 (GRCm39) missense probably damaging 1.00
R8698:Zfp974 UTSW 7 27,610,361 (GRCm39) missense possibly damaging 0.90
R8700:Zfp974 UTSW 7 27,609,472 (GRCm39) missense possibly damaging 0.86
R8938:Zfp974 UTSW 7 27,610,311 (GRCm39) missense possibly damaging 0.74
R8972:Zfp974 UTSW 7 27,610,589 (GRCm39) missense probably benign 0.06
R9212:Zfp974 UTSW 7 27,610,052 (GRCm39) missense possibly damaging 0.86
R9236:Zfp974 UTSW 7 27,610,342 (GRCm39) missense possibly damaging 0.51
R9335:Zfp974 UTSW 7 27,611,476 (GRCm39) missense probably benign 0.02
R9436:Zfp974 UTSW 7 27,611,094 (GRCm39) missense probably benign 0.24
R9740:Zfp974 UTSW 7 27,610,025 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16