Incidental Mutation 'IGL02317:Or5m3b'
ID |
288053 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Or5m3b
|
Ensembl Gene |
ENSMUSG00000045392 |
Gene Name |
olfactory receptor family 5 subfamily M member 3B |
Synonyms |
GA_x6K02T2Q125-47516301-47517233, Olfr1033, MOR199-2 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.065)
|
Stock # |
IGL02317
|
Quality Score |
|
Status
|
|
Chromosome |
2 |
Chromosomal Location |
85850984-85875152 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 85871913 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Proline
at position 85
(S85P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000151539
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000111589]
[ENSMUST00000213496]
[ENSMUST00000213774]
[ENSMUST00000213865]
[ENSMUST00000214546]
[ENSMUST00000215682]
[ENSMUST00000218397]
|
AlphaFold |
Q8VFK5 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000111589
AA Change: S85P
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000107216 Gene: ENSMUSG00000042796 AA Change: S85P
Domain | Start | End | E-Value | Type |
Pfam:7tm_4
|
29 |
306 |
2.4e-50 |
PFAM |
Pfam:7tm_1
|
39 |
288 |
3.5e-21 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000213496
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000213774
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000213865
AA Change: S85P
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000214546
AA Change: S85P
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000215682
AA Change: S85P
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000218397
AA Change: S85P
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
Meta Mutation Damage Score |
0.2397 |
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 39 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700019M22Rik |
T |
C |
12: 96,013,780 (GRCm39) |
|
noncoding transcript |
Het |
Aadacl2fm3 |
A |
G |
3: 59,784,408 (GRCm39) |
N294D |
probably benign |
Het |
Aak1 |
C |
T |
6: 86,933,282 (GRCm39) |
P418S |
possibly damaging |
Het |
Abca5 |
T |
A |
11: 110,218,587 (GRCm39) |
Q93L |
probably benign |
Het |
Arhgap22 |
G |
T |
14: 33,081,230 (GRCm39) |
V209L |
probably damaging |
Het |
Atp6v1h |
G |
T |
1: 5,154,693 (GRCm39) |
R7L |
possibly damaging |
Het |
Ccdc86 |
T |
C |
19: 10,920,556 (GRCm39) |
Q420R |
possibly damaging |
Het |
Cep85 |
C |
T |
4: 133,883,122 (GRCm39) |
G256R |
probably damaging |
Het |
Csmd2 |
T |
C |
4: 128,357,520 (GRCm39) |
|
probably benign |
Het |
Dck |
T |
C |
5: 88,921,942 (GRCm39) |
Y135H |
probably damaging |
Het |
Dicer1 |
T |
C |
12: 104,663,279 (GRCm39) |
E1434G |
probably damaging |
Het |
Dst |
C |
T |
1: 34,334,244 (GRCm39) |
T4824I |
probably damaging |
Het |
Fam20c |
G |
A |
5: 138,792,115 (GRCm39) |
R404H |
probably damaging |
Het |
Fat1 |
G |
A |
8: 45,478,855 (GRCm39) |
A2611T |
probably benign |
Het |
Fbxl13 |
C |
T |
5: 21,727,232 (GRCm39) |
C555Y |
probably benign |
Het |
Gprc6a |
C |
A |
10: 51,497,049 (GRCm39) |
R323L |
probably benign |
Het |
Grik2 |
A |
G |
10: 49,298,711 (GRCm39) |
F50L |
probably benign |
Het |
Ibsp |
A |
G |
5: 104,450,332 (GRCm39) |
Y50C |
probably damaging |
Het |
Il16 |
T |
A |
7: 83,316,097 (GRCm39) |
H437L |
probably damaging |
Het |
Irf9 |
G |
A |
14: 55,845,196 (GRCm39) |
R352H |
probably damaging |
Het |
Jph1 |
T |
C |
1: 17,074,147 (GRCm39) |
T624A |
probably benign |
Het |
Lama5 |
T |
C |
2: 179,833,112 (GRCm39) |
Y1574C |
probably damaging |
Het |
Lrrc26 |
A |
G |
2: 25,180,314 (GRCm39) |
N105S |
probably damaging |
Het |
Megf8 |
C |
A |
7: 25,063,213 (GRCm39) |
T2523K |
probably damaging |
Het |
Nckap1l |
A |
G |
15: 103,370,005 (GRCm39) |
I135V |
probably benign |
Het |
Oma1 |
A |
G |
4: 103,176,234 (GRCm39) |
|
probably benign |
Het |
Opa1 |
T |
G |
16: 29,433,984 (GRCm39) |
|
probably null |
Het |
Or13j1 |
T |
C |
4: 43,706,172 (GRCm39) |
Y132C |
probably damaging |
Het |
Or2n1 |
G |
T |
17: 38,486,577 (GRCm39) |
V201L |
probably benign |
Het |
Or8b48 |
C |
T |
9: 38,492,809 (GRCm39) |
P79S |
probably damaging |
Het |
Rab11b |
C |
T |
17: 33,968,790 (GRCm39) |
A43T |
probably damaging |
Het |
Rabl2 |
A |
T |
15: 89,468,492 (GRCm39) |
N133K |
probably damaging |
Het |
Scn10a |
C |
T |
9: 119,467,621 (GRCm39) |
V840I |
probably benign |
Het |
Spata31d1b |
T |
C |
13: 59,865,854 (GRCm39) |
S1001P |
probably damaging |
Het |
Tbc1d8 |
T |
C |
1: 39,415,985 (GRCm39) |
E896G |
probably benign |
Het |
Ube2o |
T |
C |
11: 116,432,389 (GRCm39) |
E859G |
probably damaging |
Het |
Vmn1r197 |
A |
G |
13: 22,512,073 (GRCm39) |
|
probably benign |
Het |
Vmn2r58 |
A |
G |
7: 41,486,765 (GRCm39) |
I710T |
possibly damaging |
Het |
Zmynd8 |
T |
C |
2: 165,662,492 (GRCm39) |
T533A |
possibly damaging |
Het |
|
Other mutations in Or5m3b |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01647:Or5m3b
|
APN |
2 |
85,872,441 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01745:Or5m3b
|
APN |
2 |
85,872,381 (GRCm39) |
missense |
possibly damaging |
0.74 |
IGL02400:Or5m3b
|
APN |
2 |
85,872,420 (GRCm39) |
missense |
probably benign |
0.00 |
R0692:Or5m3b
|
UTSW |
2 |
85,872,516 (GRCm39) |
missense |
probably benign |
0.00 |
R1629:Or5m3b
|
UTSW |
2 |
85,871,766 (GRCm39) |
missense |
probably damaging |
0.99 |
R2105:Or5m3b
|
UTSW |
2 |
85,871,674 (GRCm39) |
missense |
probably damaging |
0.97 |
R2288:Or5m3b
|
UTSW |
2 |
85,872,377 (GRCm39) |
nonsense |
probably null |
|
R4451:Or5m3b
|
UTSW |
2 |
85,872,303 (GRCm39) |
missense |
probably damaging |
1.00 |
R4512:Or5m3b
|
UTSW |
2 |
85,871,913 (GRCm39) |
missense |
probably damaging |
0.99 |
R4878:Or5m3b
|
UTSW |
2 |
85,871,799 (GRCm39) |
missense |
probably benign |
0.08 |
R5442:Or5m3b
|
UTSW |
2 |
85,872,295 (GRCm39) |
missense |
probably benign |
0.29 |
R5867:Or5m3b
|
UTSW |
2 |
85,871,795 (GRCm39) |
missense |
probably benign |
0.01 |
R7849:Or5m3b
|
UTSW |
2 |
85,871,949 (GRCm39) |
missense |
probably benign |
0.00 |
R7881:Or5m3b
|
UTSW |
2 |
85,871,814 (GRCm39) |
missense |
probably benign |
0.03 |
Z1088:Or5m3b
|
UTSW |
2 |
85,872,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2015-04-16 |