Incidental Mutation 'IGL00910:Prl2c5'
| ID |
28834 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Prl2c5
|
| Ensembl Gene |
ENSMUSG00000055360 |
| Gene Name |
prolactin family 2, subfamily c, member 5 |
| Synonyms |
MRP-4, Mrpplf4, PLF-4 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
IGL00910
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
13357300-13366508 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (1 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 13364061 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000117522
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021778]
[ENSMUST00000126540]
[ENSMUST00000151144]
|
| AlphaFold |
Q9JLV9 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000021778
|
| SMART Domains |
Protein: ENSMUSP00000021778
Gene: ENSMUSG00000055360
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Hormone_1
|
16 |
222 |
2.7e-70 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000126540
|
| SMART Domains |
Protein: ENSMUSP00000115024
Gene: ENSMUSG00000055360
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Hormone_1
|
19 |
225 |
1.5e-73 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143335
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000151144
|
| SMART Domains |
Protein: ENSMUSP00000117522
Gene: ENSMUSG00000055360
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Hormone_1
|
16 |
172 |
3.5e-51 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5031439G07Rik |
A |
G |
15: 84,840,020 (GRCm39) |
L109P |
probably damaging |
Het |
| Aacs |
T |
A |
5: 125,585,772 (GRCm39) |
M316K |
probably benign |
Het |
| Adarb2 |
T |
C |
13: 8,722,469 (GRCm39) |
V375A |
probably damaging |
Het |
| Adgra2 |
C |
A |
8: 27,576,011 (GRCm39) |
A13E |
possibly damaging |
Het |
| Ankrd34c |
A |
T |
9: 89,611,079 (GRCm39) |
S421T |
probably benign |
Het |
| Bpifa6 |
A |
T |
2: 153,832,386 (GRCm39) |
M298L |
probably benign |
Het |
| Casq2 |
T |
C |
3: 102,017,547 (GRCm39) |
|
probably benign |
Het |
| Ckap5 |
A |
G |
2: 91,406,395 (GRCm39) |
T762A |
probably benign |
Het |
| Dhx38 |
A |
G |
8: 110,285,666 (GRCm39) |
V389A |
probably benign |
Het |
| Dnah7b |
A |
T |
1: 46,105,889 (GRCm39) |
|
probably benign |
Het |
| Dnajc7 |
A |
T |
11: 100,490,017 (GRCm39) |
F79L |
possibly damaging |
Het |
| Dyrk3 |
A |
G |
1: 131,064,073 (GRCm39) |
I3T |
possibly damaging |
Het |
| Fchsd2 |
T |
C |
7: 100,926,833 (GRCm39) |
I641T |
probably benign |
Het |
| Furin |
A |
G |
7: 80,040,744 (GRCm39) |
V698A |
probably benign |
Het |
| Lratd1 |
T |
C |
12: 14,200,527 (GRCm39) |
S67G |
probably benign |
Het |
| Ryr3 |
A |
T |
2: 112,559,279 (GRCm39) |
|
probably benign |
Het |
| Serpina6 |
G |
T |
12: 103,618,224 (GRCm39) |
|
probably benign |
Het |
| Slc6a2 |
A |
G |
8: 93,722,728 (GRCm39) |
Y575C |
probably damaging |
Het |
| Trim9 |
T |
C |
12: 70,393,887 (GRCm39) |
E19G |
probably damaging |
Het |
| Tsfm |
G |
T |
10: 126,864,228 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Prl2c5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01874:Prl2c5
|
APN |
13 |
13,365,362 (GRCm39) |
missense |
probably benign |
|
|
IGL01878:Prl2c5
|
APN |
13 |
13,360,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0178:Prl2c5
|
UTSW |
13 |
13,366,390 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0276:Prl2c5
|
UTSW |
13 |
13,357,634 (GRCm39) |
intron |
probably benign |
|
|
R0373:Prl2c5
|
UTSW |
13 |
13,357,609 (GRCm39) |
intron |
probably benign |
|
|
R0539:Prl2c5
|
UTSW |
13 |
13,363,906 (GRCm39) |
splice site |
probably null |
|
|
R1037:Prl2c5
|
UTSW |
13 |
13,360,492 (GRCm39) |
nonsense |
probably null |
|
|
R1296:Prl2c5
|
UTSW |
13 |
13,364,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Prl2c5
|
UTSW |
13 |
13,365,310 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1557:Prl2c5
|
UTSW |
13 |
13,365,265 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1850:Prl2c5
|
UTSW |
13 |
13,360,377 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1866:Prl2c5
|
UTSW |
13 |
13,365,358 (GRCm39) |
splice site |
probably null |
|
|
R1894:Prl2c5
|
UTSW |
13 |
13,366,263 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2060:Prl2c5
|
UTSW |
13 |
13,365,238 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2330:Prl2c5
|
UTSW |
13 |
13,366,378 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4755:Prl2c5
|
UTSW |
13 |
13,363,970 (GRCm39) |
missense |
probably benign |
|
|
R5229:Prl2c5
|
UTSW |
13 |
13,360,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5364:Prl2c5
|
UTSW |
13 |
13,357,627 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6307:Prl2c5
|
UTSW |
13 |
13,365,175 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6350:Prl2c5
|
UTSW |
13 |
13,357,631 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6927:Prl2c5
|
UTSW |
13 |
13,357,503 (GRCm39) |
splice site |
probably null |
|
|
R7397:Prl2c5
|
UTSW |
13 |
13,366,327 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7965:Prl2c5
|
UTSW |
13 |
13,360,469 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8084:Prl2c5
|
UTSW |
13 |
13,360,539 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8959:Prl2c5
|
UTSW |
13 |
13,365,392 (GRCm39) |
intron |
probably benign |
|
|
R8980:Prl2c5
|
UTSW |
13 |
13,360,470 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9258:Prl2c5
|
UTSW |
13 |
13,365,297 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9465:Prl2c5
|
UTSW |
13 |
13,360,531 (GRCm39) |
missense |
probably benign |
0.42 |
|
RF020:Prl2c5
|
UTSW |
13 |
13,360,497 (GRCm39) |
missense |
probably benign |
0.28 |
|
X0025:Prl2c5
|
UTSW |
13 |
13,366,339 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Posted On |
2013-04-17 |
Incidental Mutation