Incidental Mutation 'IGL02325:Ddx25'
ID 288450
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ddx25
Ensembl Gene ENSMUSG00000032101
Gene Name DEAD box helicase 25
Synonyms DEAD (Asp-Glu-Ala-Asp) box polypeptide 25, GRTH
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.318) question?
Stock # IGL02325
Quality Score
Status
Chromosome 9
Chromosomal Location 35453144-35469766 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 35465804 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113382 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034612] [ENSMUST00000034615] [ENSMUST00000121246]
AlphaFold Q9QY15
Predicted Effect probably benign
Transcript: ENSMUST00000034612
SMART Domains Protein: ENSMUSP00000034612
Gene: ENSMUSG00000032101

DomainStartEndE-ValueType
low complexity region 50 61 N/A INTRINSIC
low complexity region 101 111 N/A INTRINSIC
DEXDc 117 316 1.26e-41 SMART
HELICc 353 440 6.18e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000034615
SMART Domains Protein: ENSMUSP00000034615
Gene: ENSMUSG00000032103

DomainStartEndE-ValueType
coiled coil region 1 46 N/A INTRINSIC
Pfam:PseudoU_synth_1 68 190 6.8e-12 PFAM
Pfam:PseudoU_synth_1 213 331 4.8e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000121246
SMART Domains Protein: ENSMUSP00000113382
Gene: ENSMUSG00000032103

DomainStartEndE-ValueType
coiled coil region 1 46 N/A INTRINSIC
Pfam:PseudoU_synth_1 68 190 3e-12 PFAM
Pfam:PseudoU_synth_1 213 316 1.5e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135768
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display male infertility, arrest of spermatogenesis at step 8, abnormal Leydig cells, and increased germ cell apoptosis in males. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acads A T 5: 115,250,013 (GRCm39) I233N probably damaging Het
Agtpbp1 C T 13: 59,648,303 (GRCm39) G393S probably benign Het
Ahctf1 T C 1: 179,603,580 (GRCm39) D822G probably benign Het
Alpk1 T C 3: 127,473,552 (GRCm39) N817S probably benign Het
Aoah G A 13: 21,101,295 (GRCm39) E272K probably damaging Het
Aoc1 A G 6: 48,882,829 (GRCm39) D235G possibly damaging Het
Ccdc186 G T 19: 56,801,788 (GRCm39) Q110K probably benign Het
Celsr2 G T 3: 108,320,187 (GRCm39) T875K probably damaging Het
Chdh T C 14: 29,754,782 (GRCm39) V264A probably benign Het
Col15a1 A G 4: 47,289,364 (GRCm39) T854A probably damaging Het
Cuedc1 A T 11: 88,060,999 (GRCm39) E114V probably null Het
Ddx23 A T 15: 98,545,074 (GRCm39) D677E possibly damaging Het
Ddx24 A G 12: 103,382,525 (GRCm39) V640A probably damaging Het
Ddx43 T C 9: 78,309,772 (GRCm39) probably benign Het
Diaph1 T C 18: 37,986,653 (GRCm39) K1111E probably damaging Het
Dnah9 T C 11: 65,725,043 (GRCm39) D4370G probably damaging Het
Eef1e1 A T 13: 38,840,012 (GRCm39) probably benign Het
Egfem1 T C 3: 29,206,066 (GRCm39) I101T probably benign Het
Gpr142 G T 11: 114,696,947 (GRCm39) L164F probably damaging Het
Gtf2h5 T A 17: 6,131,106 (GRCm39) probably null Het
Hap1 T A 11: 100,245,190 (GRCm39) probably null Het
Hemgn T G 4: 46,396,085 (GRCm39) I384L probably benign Het
Ints3 A T 3: 90,311,349 (GRCm39) H419Q probably damaging Het
Itgb2 T C 10: 77,383,026 (GRCm39) L132P probably damaging Het
Krtap29-1 C T 11: 99,869,159 (GRCm39) V241M probably damaging Het
Lrguk A G 6: 34,106,114 (GRCm39) E713G probably benign Het
Lrrk2 G T 15: 91,610,511 (GRCm39) probably null Het
Nlrp14 A G 7: 106,781,523 (GRCm39) D240G possibly damaging Het
Omt2b A T 9: 78,235,854 (GRCm39) T60S possibly damaging Het
Or10ag52 G T 2: 87,043,850 (GRCm39) G205W probably damaging Het
Pcdhb2 A G 18: 37,429,733 (GRCm39) N569D possibly damaging Het
Plcd3 G A 11: 102,971,447 (GRCm39) R66* probably null Het
Polr1a G A 6: 71,897,641 (GRCm39) R212Q probably benign Het
Pou3f2 A T 4: 22,487,020 (GRCm39) L371Q probably damaging Het
Rnf207 A T 4: 152,396,237 (GRCm39) I509N probably damaging Het
Sema5a T G 15: 32,686,977 (GRCm39) S1030A possibly damaging Het
Shank1 C A 7: 43,976,504 (GRCm39) S534* probably null Het
Sntg2 T C 12: 30,245,542 (GRCm39) T495A probably benign Het
Spem2 A T 11: 69,707,789 (GRCm39) V392D probably benign Het
Srrm2 T A 17: 24,029,453 (GRCm39) probably benign Het
Tbc1d8 A T 1: 39,433,321 (GRCm39) F287Y probably damaging Het
Tgfbi A G 13: 56,779,043 (GRCm39) D422G probably benign Het
Tppp G A 13: 74,169,295 (GRCm39) A12T probably benign Het
Usp46 C T 5: 74,197,689 (GRCm39) probably null Het
Zdhhc12 C T 2: 29,981,448 (GRCm39) V205I probably damaging Het
Other mutations in Ddx25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Ddx25 APN 9 35,454,891 (GRCm39) splice site probably benign
IGL00951:Ddx25 APN 9 35,464,131 (GRCm39) critical splice donor site probably null
IGL02237:Ddx25 APN 9 35,453,365 (GRCm39) splice site probably benign
IGL02270:Ddx25 APN 9 35,465,708 (GRCm39) splice site probably benign
IGL02273:Ddx25 APN 9 35,458,122 (GRCm39) missense possibly damaging 0.95
IGL02422:Ddx25 APN 9 35,462,660 (GRCm39) missense probably null 1.00
IGL02440:Ddx25 APN 9 35,468,974 (GRCm39) unclassified probably benign
IGL02798:Ddx25 APN 9 35,462,693 (GRCm39) missense probably damaging 1.00
IGL03339:Ddx25 APN 9 35,453,299 (GRCm39) missense probably damaging 1.00
R0633:Ddx25 UTSW 9 35,457,268 (GRCm39) missense probably damaging 0.99
R0893:Ddx25 UTSW 9 35,465,686 (GRCm39) nonsense probably null
R1171:Ddx25 UTSW 9 35,458,142 (GRCm39) nonsense probably null
R1448:Ddx25 UTSW 9 35,469,034 (GRCm39) missense probably benign
R1453:Ddx25 UTSW 9 35,453,298 (GRCm39) missense probably damaging 1.00
R1582:Ddx25 UTSW 9 35,457,272 (GRCm39) missense probably damaging 0.97
R3055:Ddx25 UTSW 9 35,462,647 (GRCm39) missense probably damaging 1.00
R5960:Ddx25 UTSW 9 35,465,807 (GRCm39) splice site probably null
R7425:Ddx25 UTSW 9 35,465,882 (GRCm39) missense probably benign 0.08
R7535:Ddx25 UTSW 9 35,454,951 (GRCm39) missense possibly damaging 0.89
R7610:Ddx25 UTSW 9 35,465,893 (GRCm39) missense possibly damaging 0.90
R8758:Ddx25 UTSW 9 35,453,300 (GRCm39) missense probably benign
R8931:Ddx25 UTSW 9 35,465,864 (GRCm39) missense possibly damaging 0.85
R8984:Ddx25 UTSW 9 35,468,685 (GRCm39) missense probably benign
R9103:Ddx25 UTSW 9 35,458,085 (GRCm39) missense probably benign 0.24
R9585:Ddx25 UTSW 9 35,455,009 (GRCm39) nonsense probably null
R9759:Ddx25 UTSW 9 35,457,265 (GRCm39) missense probably benign 0.00
Posted On 2015-04-16