Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02327:Cyp2a22'

288508

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2a22

Ensembl Gene

ENSMUSG00000091867

Gene Name

cytochrome P450, family 2, subfamily a, polypeptide 22

Synonyms

EG233005

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.185) question?

Stock #

IGL02327

Quality Score

Status

Chromosome

Chromosomal Location

26931631-26939384 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 26934781 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 316 (M316K)

Ref Sequence

ENSEMBL: ENSMUSP00000128030 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170227]

Predicted Effect

probably damaging
Transcript: ENSMUST00000170227
AA Change: M316K

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000128030
Gene: ENSMUSG00000091867
AA Change: M316K

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
Pfam:p450	33	489	7.4e-148	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206638

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206957

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd9	A	T	12: 110,977,415	C29S	probably damaging	Het
Ccdc66	G	A	14: 27,493,386	A399V	probably damaging	Het
Ccl12	A	G	11: 82,103,122	I68M	possibly damaging	Het
Cd244	T	C	1: 171,559,341	V6A	probably benign	Het
Cfap97	T	A	8: 46,170,142	S190T	probably damaging	Het
Chic2	G	T	5: 75,027,080	C106*	probably null	Het
Ctdsp2	G	A	10: 126,996,382	D237N	probably benign	Het
Cyp3a25	A	G	5: 145,986,921	F304S	possibly damaging	Het
Ddc	A	T	11: 11,863,739	V209D	probably damaging	Het
Dhx16	A	G	17: 35,883,825	K446R	probably benign	Het
Fgd3	T	C	13: 49,285,798	K241E	probably damaging	Het
Hps1	G	T	19: 42,756,345		probably benign	Het
Inpp4b	C	T	8: 82,041,962	T700I	probably benign	Het
Kremen2	T	A	17: 23,743,569	M157L	probably benign	Het
Lrwd1	T	C	5: 136,123,464	Y582C	probably damaging	Het
Macf1	T	A	4: 123,471,730	R1514S	probably benign	Het
Mex3c	T	A	18: 73,590,710	C625S	probably damaging	Het
Mical1	G	A	10: 41,486,664	E932K	possibly damaging	Het
Ncf2	A	T	1: 152,816,993	Y87F	possibly damaging	Het
Neo1	T	C	9: 58,903,088	T1027A	probably benign	Het
Nfkbib	G	T	7: 28,759,143	P347Q	probably benign	Het
Nr1h2	G	A	7: 44,551,500		probably benign	Het
Olfr1158	A	T	2: 87,990,257	I49F	probably damaging	Het
Olfr224	T	A	11: 58,566,935	R137W	probably damaging	Het
Olfr384	A	T	11: 73,603,155	T192S	probably damaging	Het
Oxct1	A	G	15: 4,037,089		probably null	Het
Pak1ip1	T	G	13: 41,012,417	N308K	probably benign	Het
Prpf38a	T	C	4: 108,568,410	R224G	unknown	Het
Scfd1	T	C	12: 51,389,317	V83A	possibly damaging	Het
Tmem131	C	T	1: 36,799,022	G1545D	probably damaging	Het
Trav13n-4	A	T	14: 53,364,110		probably benign	Het
Ttc3	A	G	16: 94,448,108	D1155G	probably damaging	Het
Unc80	G	A	1: 66,641,673	V2143I	probably benign	Het
Vmn2r16	T	C	5: 109,340,121	Y287H	probably benign	Het
Vmn2r59	A	G	7: 42,012,231	V720A	probably benign	Het
Wars	T	A	12: 108,866,301		probably null	Het
Wdcp	A	G	12: 4,851,115	K324E	possibly damaging	Het
Wdfy3	A	T	5: 101,888,192	L2105H	probably damaging	Het
Xirp2	A	T	2: 67,510,100	D895V	probably damaging	Het
Zscan10	A	T	17: 23,607,572		probably benign	Het

Other mutations in Cyp2a22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00156:Cyp2a22	APN	7	26937738	missense	probably benign	0.09
IGL01111:Cyp2a22	APN	7	26936458	missense	probably damaging	1.00
IGL01388:Cyp2a22	APN	7	26937792	missense	probably benign	0.02
IGL01449:Cyp2a22	APN	7	26933553	missense	probably benign	0.01
IGL01642:Cyp2a22	APN	7	26938759	missense	possibly damaging	0.81
IGL02253:Cyp2a22	APN	7	26938237	splice site	probably benign
IGL02673:Cyp2a22	APN	7	26938100	missense	probably benign	0.00
IGL02813:Cyp2a22	APN	7	26936434	missense	probably benign	0.19
IGL02896:Cyp2a22	APN	7	26936461	missense	probably damaging	0.98
IGL03193:Cyp2a22	APN	7	26936421	missense	probably benign	0.00
IGL03350:Cyp2a22	APN	7	26934854	missense	possibly damaging	0.88
R1648:Cyp2a22	UTSW	7	26932368	missense	probably damaging	0.98
R1679:Cyp2a22	UTSW	7	26936311	nonsense	probably null
R1733:Cyp2a22	UTSW	7	26934762	missense	possibly damaging	0.78
R2001:Cyp2a22	UTSW	7	26934772	missense	probably damaging	1.00
R2858:Cyp2a22	UTSW	7	26934262	missense	probably damaging	0.99
R3054:Cyp2a22	UTSW	7	26938829	missense	probably damaging	1.00
R4528:Cyp2a22	UTSW	7	26934769	missense	possibly damaging	0.95
R4623:Cyp2a22	UTSW	7	26933491	missense	probably damaging	1.00
R4669:Cyp2a22	UTSW	7	26937855	missense	possibly damaging	0.88
R4690:Cyp2a22	UTSW	7	26939209	nonsense	probably null
R4840:Cyp2a22	UTSW	7	26932524	missense	probably benign	0.13
R4915:Cyp2a22	UTSW	7	26937770	missense	probably benign	0.33
R5071:Cyp2a22	UTSW	7	26932481	missense	probably benign	0.01
R5072:Cyp2a22	UTSW	7	26932481	missense	probably benign	0.01
R5074:Cyp2a22	UTSW	7	26932481	missense	probably benign	0.01
R5147:Cyp2a22	UTSW	7	26936325	missense	probably damaging	1.00
R5363:Cyp2a22	UTSW	7	26936433	missense	probably damaging	0.99
R5705:Cyp2a22	UTSW	7	26939215	missense	probably benign	0.05
R6014:Cyp2a22	UTSW	7	26939180	splice site	probably null
R6042:Cyp2a22	UTSW	7	26934239	missense	probably damaging	1.00
R6253:Cyp2a22	UTSW	7	26934232	missense	probably benign	0.18
R6757:Cyp2a22	UTSW	7	26939204	missense	probably benign	0.00

Posted On

2015-04-16