Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02327:Zscan10'

288545

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zscan10

Ensembl Gene

ENSMUSG00000023902

Gene Name

zinc finger and SCAN domain containing 10

Synonyms

Zscan10, Zfp206

Accession Numbers

Ncbi RefSeq: NM_001033425.3; MGI:3040700

Is this an essential gene?

Possibly non essential (E-score: 0.353) question?

Stock #

IGL02327

Quality Score

Status

Chromosome

Chromosomal Location

23600856-23611019 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 23607572 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000120876 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095595] [ENSMUST00000115509] [ENSMUST00000117606] [ENSMUST00000118369] [ENSMUST00000120967] [ENSMUST00000122285] [ENSMUST00000123866] [ENSMUST00000129227] [ENSMUST00000138487] [ENSMUST00000148062]

Predicted Effect

probably benign
Transcript: ENSMUST00000095595

SMART Domains

Protein: ENSMUSP00000093255
Gene: ENSMUSG00000023902

Domain	Start	End	E-Value	Type
SCAN	39	145	1.28e-34	SMART
low complexity region	173	194	N/A	INTRINSIC
ZnF_C2H2	343	366	4.4e-2	SMART
ZnF_C2H2	378	400	5.59e-4	SMART
ZnF_C2H2	406	428	1.25e-1	SMART
ZnF_C2H2	434	456	2.05e-2	SMART
ZnF_C2H2	478	500	2.75e-3	SMART
low complexity region	507	521	N/A	INTRINSIC
ZnF_C2H2	524	547	1.82e-3	SMART
ZnF_C2H2	553	575	3.16e-3	SMART
ZnF_C2H2	581	603	1.95e-3	SMART
ZnF_C2H2	609	631	4.17e-3	SMART
ZnF_C2H2	637	659	1.56e-2	SMART
ZnF_C2H2	665	687	2.4e-3	SMART
ZnF_C2H2	693	715	1.98e-4	SMART
ZnF_C2H2	726	748	1.58e-3	SMART
ZnF_C2H2	754	776	6.42e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000115509

SMART Domains

Protein: ENSMUSP00000111171
Gene: ENSMUSG00000023902

Domain	Start	End	E-Value	Type
SCAN	39	148	3.37e-34	SMART
ZnF_C2H2	233	256	4.4e-2	SMART
ZnF_C2H2	268	290	5.59e-4	SMART
ZnF_C2H2	296	318	1.25e-1	SMART
ZnF_C2H2	324	346	2.05e-2	SMART
ZnF_C2H2	368	390	2.75e-3	SMART
low complexity region	397	411	N/A	INTRINSIC
ZnF_C2H2	414	437	1.82e-3	SMART
ZnF_C2H2	443	465	3.16e-3	SMART
ZnF_C2H2	471	493	1.95e-3	SMART
ZnF_C2H2	499	521	4.17e-3	SMART
ZnF_C2H2	527	549	1.56e-2	SMART
ZnF_C2H2	555	577	2.4e-3	SMART
ZnF_C2H2	583	605	1.98e-4	SMART
ZnF_C2H2	616	638	1.58e-3	SMART
ZnF_C2H2	644	666	6.42e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000117606

SMART Domains

Protein: ENSMUSP00000112460
Gene: ENSMUSG00000023902

Domain	Start	End	E-Value	Type
SCAN	39	147	1.73e-31	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000118369

SMART Domains

Protein: ENSMUSP00000113757
Gene: ENSMUSG00000023902

Domain	Start	End	E-Value	Type
SCAN	39	152	1.59e-30	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000120967

SMART Domains

Protein: ENSMUSP00000113386
Gene: ENSMUSG00000023902

Domain	Start	End	E-Value	Type
SCAN	39	145	1.28e-34	SMART
low complexity region	173	194	N/A	INTRINSIC
ZnF_C2H2	346	368	5.59e-4	SMART
ZnF_C2H2	374	396	1.25e-1	SMART
ZnF_C2H2	402	424	2.05e-2	SMART
ZnF_C2H2	446	468	2.75e-3	SMART
low complexity region	475	489	N/A	INTRINSIC
ZnF_C2H2	492	515	1.82e-3	SMART
ZnF_C2H2	521	543	3.16e-3	SMART
ZnF_C2H2	549	571	1.95e-3	SMART
ZnF_C2H2	577	599	4.17e-3	SMART
ZnF_C2H2	605	627	1.56e-2	SMART
ZnF_C2H2	633	655	2.4e-3	SMART
ZnF_C2H2	661	683	1.98e-4	SMART
ZnF_C2H2	694	716	1.58e-3	SMART
ZnF_C2H2	722	744	6.42e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000122285

SMART Domains

Protein: ENSMUSP00000112559
Gene: ENSMUSG00000023902

Domain	Start	End	E-Value	Type
SCAN	39	152	1.59e-30	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000123866

SMART Domains

Protein: ENSMUSP00000116748
Gene: ENSMUSG00000023902

Domain	Start	End	E-Value	Type
SCAN	39	148	2.38e-34	SMART
ZnF_C2H2	267	290	4.4e-2	SMART
ZnF_C2H2	302	324	5.59e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125912

Predicted Effect

probably benign
Transcript: ENSMUST00000129227

SMART Domains

Protein: ENSMUSP00000118987
Gene: ENSMUSG00000023902

Domain	Start	End	E-Value	Type
ZnF_C2H2	142	164	5.59e-4	SMART
ZnF_C2H2	170	192	1.25e-1	SMART
ZnF_C2H2	198	220	2.05e-2	SMART
ZnF_C2H2	242	264	2.75e-3	SMART
low complexity region	271	285	N/A	INTRINSIC
ZnF_C2H2	288	311	1.82e-3	SMART
ZnF_C2H2	317	339	3.16e-3	SMART
ZnF_C2H2	345	367	1.95e-3	SMART
ZnF_C2H2	373	395	4.17e-3	SMART
ZnF_C2H2	401	423	1.56e-2	SMART
ZnF_C2H2	429	451	2.4e-3	SMART
ZnF_C2H2	457	479	1.98e-4	SMART
ZnF_C2H2	490	512	1.58e-3	SMART
ZnF_C2H2	518	540	6.42e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133749

Predicted Effect

probably benign
Transcript: ENSMUST00000138487

SMART Domains

Protein: ENSMUSP00000114341
Gene: ENSMUSG00000023902

Domain	Start	End	E-Value	Type
SCAN	39	148	3.37e-34	SMART
ZnF_C2H2	236	258	5.59e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000148062

SMART Domains

Protein: ENSMUSP00000120876
Gene: ENSMUSG00000023902

Domain	Start	End	E-Value	Type
Pfam:SCAN	37	88	7.5e-20	PFAM
low complexity region	128	149	N/A	INTRINSIC
ZnF_C2H2	301	323	5.59e-4	SMART
ZnF_C2H2	329	351	1.25e-1	SMART
ZnF_C2H2	357	379	2.05e-2	SMART
ZnF_C2H2	401	423	2.75e-3	SMART
low complexity region	430	444	N/A	INTRINSIC
ZnF_C2H2	447	470	1.82e-3	SMART
ZnF_C2H2	476	498	3.16e-3	SMART
ZnF_C2H2	504	526	1.95e-3	SMART
ZnF_C2H2	532	554	4.17e-3	SMART
ZnF_C2H2	560	582	1.56e-2	SMART
ZnF_C2H2	588	610	2.4e-3	SMART
ZnF_C2H2	616	638	1.98e-4	SMART
ZnF_C2H2	649	671	1.58e-3	SMART
ZnF_C2H2	677	699	6.42e-4	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a gene trap allele exhibit a pleiotropic phenotype including reduced weight, mild hypoplasia in the spleen, heart and long bones, eye malformations including microphthalmia, altered platelet counts, an activated immune status, and behavioral alterations. [provided by MGI curators]

Allele List at MGI

All alleles(357) : Targeted(5) Gene trapped(352)

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd9	A	T	12: 110,977,415	C29S	probably damaging	Het
Ccdc66	G	A	14: 27,493,386	A399V	probably damaging	Het
Ccl12	A	G	11: 82,103,122	I68M	possibly damaging	Het
Cd244	T	C	1: 171,559,341	V6A	probably benign	Het
Cfap97	T	A	8: 46,170,142	S190T	probably damaging	Het
Chic2	G	T	5: 75,027,080	C106*	probably null	Het
Ctdsp2	G	A	10: 126,996,382	D237N	probably benign	Het
Cyp2a22	A	T	7: 26,934,781	M316K	probably damaging	Het
Cyp3a25	A	G	5: 145,986,921	F304S	possibly damaging	Het
Ddc	A	T	11: 11,863,739	V209D	probably damaging	Het
Dhx16	A	G	17: 35,883,825	K446R	probably benign	Het
Fgd3	T	C	13: 49,285,798	K241E	probably damaging	Het
Hps1	G	T	19: 42,756,345		probably benign	Het
Inpp4b	C	T	8: 82,041,962	T700I	probably benign	Het
Kremen2	T	A	17: 23,743,569	M157L	probably benign	Het
Lrwd1	T	C	5: 136,123,464	Y582C	probably damaging	Het
Macf1	T	A	4: 123,471,730	R1514S	probably benign	Het
Mex3c	T	A	18: 73,590,710	C625S	probably damaging	Het
Mical1	G	A	10: 41,486,664	E932K	possibly damaging	Het
Ncf2	A	T	1: 152,816,993	Y87F	possibly damaging	Het
Neo1	T	C	9: 58,903,088	T1027A	probably benign	Het
Nfkbib	G	T	7: 28,759,143	P347Q	probably benign	Het
Nr1h2	G	A	7: 44,551,500		probably benign	Het
Olfr1158	A	T	2: 87,990,257	I49F	probably damaging	Het
Olfr224	T	A	11: 58,566,935	R137W	probably damaging	Het
Olfr384	A	T	11: 73,603,155	T192S	probably damaging	Het
Oxct1	A	G	15: 4,037,089		probably null	Het
Pak1ip1	T	G	13: 41,012,417	N308K	probably benign	Het
Prpf38a	T	C	4: 108,568,410	R224G	unknown	Het
Scfd1	T	C	12: 51,389,317	V83A	possibly damaging	Het
Tmem131	C	T	1: 36,799,022	G1545D	probably damaging	Het
Trav13n-4	A	T	14: 53,364,110		probably benign	Het
Ttc3	A	G	16: 94,448,108	D1155G	probably damaging	Het
Unc80	G	A	1: 66,641,673	V2143I	probably benign	Het
Vmn2r16	T	C	5: 109,340,121	Y287H	probably benign	Het
Vmn2r59	A	G	7: 42,012,231	V720A	probably benign	Het
Wars	T	A	12: 108,866,301		probably null	Het
Wdcp	A	G	12: 4,851,115	K324E	possibly damaging	Het
Wdfy3	A	T	5: 101,888,192	L2105H	probably damaging	Het
Xirp2	A	T	2: 67,510,100	D895V	probably damaging	Het

Other mutations in Zscan10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00572:Zscan10	APN	17	23609461	missense	probably damaging	0.98
IGL01353:Zscan10	APN	17	23609600	missense	probably damaging	1.00
IGL02556:Zscan10	APN	17	23608145	missense	possibly damaging	0.90
FR4737:Zscan10	UTSW	17	23609445	small deletion	probably benign
P0043:Zscan10	UTSW	17	23609620	nonsense	probably null
R0345:Zscan10	UTSW	17	23610082	missense	probably damaging	1.00
R0401:Zscan10	UTSW	17	23605915	missense	probably damaging	1.00
R0699:Zscan10	UTSW	17	23608118	missense	probably damaging	1.00
R0838:Zscan10	UTSW	17	23610034	missense	possibly damaging	0.83
R0919:Zscan10	UTSW	17	23610007	missense	probably damaging	0.99
R1940:Zscan10	UTSW	17	23609852	missense	probably damaging	1.00
R4647:Zscan10	UTSW	17	23610340	missense	probably benign
R4753:Zscan10	UTSW	17	23607234	missense	probably damaging	0.99
R4971:Zscan10	UTSW	17	23607173	missense	possibly damaging	0.67
R5110:Zscan10	UTSW	17	23609632	missense	probably damaging	1.00
R5410:Zscan10	UTSW	17	23610421	missense	probably damaging	1.00
R5516:Zscan10	UTSW	17	23609359	missense	possibly damaging	0.66
R5871:Zscan10	UTSW	17	23607267	intron	probably benign
R6109:Zscan10	UTSW	17	23607129	missense	probably damaging	0.98
R6626:Zscan10	UTSW	17	23605857	missense	probably damaging	1.00
R6750:Zscan10	UTSW	17	23607190	missense	possibly damaging	0.49
R6846:Zscan10	UTSW	17	23605607	missense	probably damaging	0.97

Posted On

2015-04-16