Incidental Mutation 'IGL02329:Zfp341'
| ID |
288613 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp341
|
| Ensembl Gene |
ENSMUSG00000059842 |
| Gene Name |
zinc finger protein 341 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02329
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
154455217-154488741 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 154474224 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 343
(C343R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105324
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081926]
[ENSMUST00000109702]
[ENSMUST00000126421]
|
| AlphaFold |
Q6PGC9 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000081926
AA Change: C350R
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000080596
Gene: ENSMUSG00000059842
AA Change: C350R
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
53 |
73 |
4.16e1 |
SMART |
|
low complexity region
|
96 |
110 |
N/A |
INTRINSIC |
|
low complexity region
|
154 |
161 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
200 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
320 |
342 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
348 |
370 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
470 |
494 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
537 |
561 |
1.23e0 |
SMART |
|
ZnF_C2H2
|
563 |
585 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
591 |
613 |
1.62e0 |
SMART |
|
ZnF_C2H2
|
619 |
641 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
647 |
674 |
7.29e0 |
SMART |
|
ZnF_C2H2
|
680 |
702 |
5.14e-3 |
SMART |
|
low complexity region
|
740 |
759 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109702
AA Change: C343R
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000105324
Gene: ENSMUSG00000059842
AA Change: C343R
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
53 |
73 |
4.16e1 |
SMART |
|
low complexity region
|
96 |
110 |
N/A |
INTRINSIC |
|
low complexity region
|
154 |
161 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
200 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
313 |
335 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
341 |
363 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
463 |
487 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
493 |
515 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
530 |
554 |
1.23e0 |
SMART |
|
ZnF_C2H2
|
556 |
578 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
584 |
606 |
1.62e0 |
SMART |
|
ZnF_C2H2
|
612 |
634 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
640 |
667 |
7.29e0 |
SMART |
|
ZnF_C2H2
|
673 |
695 |
5.14e-3 |
SMART |
|
low complexity region
|
733 |
752 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126421
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153208
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atg2a |
T |
C |
19: 6,299,959 (GRCm39) |
|
probably null |
Het |
| Bfsp1 |
T |
C |
2: 143,704,566 (GRCm39) |
T96A |
probably benign |
Het |
| Btnl1 |
A |
G |
17: 34,601,239 (GRCm39) |
E322G |
possibly damaging |
Het |
| Cand2 |
T |
C |
6: 115,766,568 (GRCm39) |
V391A |
probably damaging |
Het |
| Ccdc169 |
A |
G |
3: 55,078,702 (GRCm39) |
M188V |
probably benign |
Het |
| Cngb1 |
T |
C |
8: 95,968,987 (GRCm39) |
I1174V |
probably benign |
Het |
| Cpeb4 |
T |
C |
11: 31,822,316 (GRCm39) |
V10A |
possibly damaging |
Het |
| Cpt1b |
T |
C |
15: 89,307,942 (GRCm39) |
T206A |
probably benign |
Het |
| Dapk3 |
T |
C |
10: 81,025,999 (GRCm39) |
S97P |
probably benign |
Het |
| Drc3 |
T |
C |
11: 60,261,404 (GRCm39) |
L185P |
probably damaging |
Het |
| Efr3b |
T |
C |
12: 4,042,923 (GRCm39) |
|
probably null |
Het |
| Erbb3 |
T |
A |
10: 128,409,088 (GRCm39) |
I742F |
probably damaging |
Het |
| Fktn |
A |
G |
4: 53,720,181 (GRCm39) |
Y65C |
probably benign |
Het |
| Fstl5 |
G |
A |
3: 76,496,302 (GRCm39) |
G355D |
probably damaging |
Het |
| Grm8 |
A |
T |
6: 27,363,115 (GRCm39) |
I800N |
probably damaging |
Het |
| Gss |
C |
T |
2: 155,409,773 (GRCm39) |
R221H |
probably benign |
Het |
| H2-M10.4 |
A |
T |
17: 36,771,359 (GRCm39) |
V273D |
probably damaging |
Het |
| Large1 |
C |
A |
8: 73,774,945 (GRCm39) |
W255L |
possibly damaging |
Het |
| Meig1 |
T |
C |
2: 3,410,288 (GRCm39) |
K71E |
probably damaging |
Het |
| Mtor |
A |
G |
4: 148,619,396 (GRCm39) |
N1760D |
probably benign |
Het |
| Ncapd2 |
A |
T |
6: 125,166,781 (GRCm39) |
N24K |
probably damaging |
Het |
| Nphp3 |
A |
C |
9: 103,903,167 (GRCm39) |
S715R |
probably benign |
Het |
| Papolg |
T |
G |
11: 23,841,869 (GRCm39) |
H18P |
probably damaging |
Het |
| Psd |
T |
C |
19: 46,308,098 (GRCm39) |
H667R |
possibly damaging |
Het |
| Rita1 |
C |
T |
5: 120,747,858 (GRCm39) |
A147T |
probably damaging |
Het |
| Rtp1 |
T |
C |
16: 23,249,943 (GRCm39) |
S103P |
probably damaging |
Het |
| Snx21 |
T |
C |
2: 164,634,310 (GRCm39) |
|
probably benign |
Het |
| Spmip3 |
A |
T |
1: 177,570,867 (GRCm39) |
Q67L |
probably benign |
Het |
| Tiam1 |
G |
T |
16: 89,596,924 (GRCm39) |
H301N |
probably benign |
Het |
| Trcg1 |
A |
T |
9: 57,147,676 (GRCm39) |
I11F |
possibly damaging |
Het |
| Trpm6 |
A |
G |
19: 18,831,581 (GRCm39) |
K1482R |
probably benign |
Het |
| Tyw1 |
G |
T |
5: 130,295,921 (GRCm39) |
G116V |
probably benign |
Het |
|
| Other mutations in Zfp341 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00499:Zfp341
|
APN |
2 |
154,476,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01352:Zfp341
|
APN |
2 |
154,470,816 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01748:Zfp341
|
APN |
2 |
154,470,847 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02260:Zfp341
|
APN |
2 |
154,483,969 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
casanova_grimbacher
|
UTSW |
2 |
154,466,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Specious
|
UTSW |
2 |
154,488,054 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R0079:Zfp341
|
UTSW |
2 |
154,466,914 (GRCm39) |
nonsense |
probably null |
|
|
R0570:Zfp341
|
UTSW |
2 |
154,487,988 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0620:Zfp341
|
UTSW |
2 |
154,476,193 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1018:Zfp341
|
UTSW |
2 |
154,487,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1611:Zfp341
|
UTSW |
2 |
154,487,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1733:Zfp341
|
UTSW |
2 |
154,483,298 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1822:Zfp341
|
UTSW |
2 |
154,488,054 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1956:Zfp341
|
UTSW |
2 |
154,480,132 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2437:Zfp341
|
UTSW |
2 |
154,470,721 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3623:Zfp341
|
UTSW |
2 |
154,466,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4417:Zfp341
|
UTSW |
2 |
154,470,907 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4806:Zfp341
|
UTSW |
2 |
154,487,786 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4807:Zfp341
|
UTSW |
2 |
154,487,786 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4863:Zfp341
|
UTSW |
2 |
154,487,786 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4955:Zfp341
|
UTSW |
2 |
154,479,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4962:Zfp341
|
UTSW |
2 |
154,468,734 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5484:Zfp341
|
UTSW |
2 |
154,466,921 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5864:Zfp341
|
UTSW |
2 |
154,485,474 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5877:Zfp341
|
UTSW |
2 |
154,474,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5975:Zfp341
|
UTSW |
2 |
154,472,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5990:Zfp341
|
UTSW |
2 |
154,487,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6057:Zfp341
|
UTSW |
2 |
154,466,954 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6882:Zfp341
|
UTSW |
2 |
154,479,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7686:Zfp341
|
UTSW |
2 |
154,466,781 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7701:Zfp341
|
UTSW |
2 |
154,476,000 (GRCm39) |
splice site |
probably null |
|
|
R7847:Zfp341
|
UTSW |
2 |
154,476,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8109:Zfp341
|
UTSW |
2 |
154,469,820 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9313:Zfp341
|
UTSW |
2 |
154,469,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Zfp341
|
UTSW |
2 |
154,485,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation