Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02330:Vmn1r123'

288620

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r123

Ensembl Gene

ENSMUSG00000094385

Gene Name

vomeronasal 1 receptor 123

Synonyms

LOC384695, Gm1446

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02330

Quality Score

Status

Chromosome

Chromosomal Location

20896110-20897033 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20896969 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 287 (I287N)

Ref Sequence

ENSEMBL: ENSMUSP00000125823 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166948]

AlphaFold

L7N270

Predicted Effect

probably damaging
Transcript: ENSMUST00000166948
AA Change: I287N

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000125823
Gene: ENSMUSG00000094385
AA Change: I287N

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	299	7e-18	PFAM
Pfam:7tm_1	31	291	2.1e-8	PFAM
Pfam:V1R	41	298	1.9e-16	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam29	A	T	8: 56,325,398 (GRCm39)	I352K	probably benign	Het
Atp8a1	T	C	5: 67,970,520 (GRCm39)	N73S	probably damaging	Het
Cilp	T	C	9: 65,181,804 (GRCm39)		probably benign	Het
Csf2rb2	C	T	15: 78,169,328 (GRCm39)	G500D	possibly damaging	Het
Cyp4a14	A	C	4: 115,352,224 (GRCm39)		probably benign	Het
Dagla	T	G	19: 10,225,386 (GRCm39)	D926A	probably damaging	Het
Ddr2	T	A	1: 169,816,093 (GRCm39)	Y538F	probably damaging	Het
Eng	T	A	2: 32,559,581 (GRCm39)		probably null	Het
Fbxo24	G	T	5: 137,619,579 (GRCm39)	L99M	probably damaging	Het
Fmn2	A	G	1: 174,437,511 (GRCm39)	S1161G	probably benign	Het
Foxp1	T	C	6: 98,922,373 (GRCm39)	N453D	probably damaging	Het
Fut8	A	G	12: 77,497,017 (GRCm39)	D409G	probably damaging	Het
Hmces	A	G	6: 87,891,517 (GRCm39)	H8R	probably damaging	Het
Ing3	T	C	6: 21,952,120 (GRCm39)	C44R	probably benign	Het
Itga1	T	A	13: 115,148,740 (GRCm39)	I294F	probably damaging	Het
Mov10l1	T	A	15: 88,910,693 (GRCm39)	S976T	probably damaging	Het
Myo15a	A	G	11: 60,367,987 (GRCm39)	Y249C	possibly damaging	Het
Nop56	T	C	2: 130,118,686 (GRCm39)	S273P	probably damaging	Het
Or10a48	A	T	7: 108,425,206 (GRCm39)		probably benign	Het
Or1j21	C	T	2: 36,683,907 (GRCm39)	H220Y	probably benign	Het
Otog	C	T	7: 45,937,493 (GRCm39)	S1734F	possibly damaging	Het
Phc3	T	G	3: 30,990,530 (GRCm39)	E562D	probably damaging	Het
Ralb	A	T	1: 119,399,450 (GRCm39)	C203S	probably damaging	Het
Rita1	C	T	5: 120,747,858 (GRCm39)	A147T	probably damaging	Het
Sf3b4	A	T	3: 96,080,376 (GRCm39)	T42S	possibly damaging	Het
Sgsm2	T	C	11: 74,749,493 (GRCm39)	T584A	probably benign	Het
Slco5a1	T	C	1: 13,009,284 (GRCm39)	K397R	probably damaging	Het
Trim30c	A	G	7: 104,032,165 (GRCm39)	Y299H	possibly damaging	Het
Trip6	T	C	5: 137,311,620 (GRCm39)	D119G	probably benign	Het
Uap1	A	T	1: 169,977,896 (GRCm39)	I385N	possibly damaging	Het
Vwce	T	C	19: 10,624,165 (GRCm39)	L352P	possibly damaging	Het
Xrn1	T	A	9: 95,855,401 (GRCm39)	Y260*	probably null	Het
Zfp738	T	C	13: 67,819,550 (GRCm39)	Y147C	probably damaging	Het

Other mutations in Vmn1r123

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00927:Vmn1r123	APN	7	20,896,216 (GRCm39)	missense	possibly damaging	0.93
IGL02742:Vmn1r123	APN	7	20,896,968 (GRCm39)	missense	possibly damaging	0.93
IGL03240:Vmn1r123	APN	7	20,896,282 (GRCm39)	missense	possibly damaging	0.94
R1173:Vmn1r123	UTSW	7	20,896,257 (GRCm39)	missense	probably damaging	0.99
R6278:Vmn1r123	UTSW	7	20,896,774 (GRCm39)	missense	possibly damaging	0.78
R6610:Vmn1r123	UTSW	7	20,896,515 (GRCm39)	missense	probably benign	0.00
R6679:Vmn1r123	UTSW	7	20,896,868 (GRCm39)	nonsense	probably null
R7241:Vmn1r123	UTSW	7	20,896,537 (GRCm39)	missense	possibly damaging	0.95
R7642:Vmn1r123	UTSW	7	20,896,795 (GRCm39)	missense	probably benign	0.11
R7702:Vmn1r123	UTSW	7	20,896,302 (GRCm39)	missense	probably damaging	0.99
R7870:Vmn1r123	UTSW	7	20,896,192 (GRCm39)	missense	probably damaging	1.00
R7981:Vmn1r123	UTSW	7	20,896,914 (GRCm39)	missense	probably damaging	0.98
R8554:Vmn1r123	UTSW	7	20,896,971 (GRCm39)	missense	probably benign
R9079:Vmn1r123	UTSW	7	20,896,979 (GRCm39)	missense	probably benign	0.01
R9090:Vmn1r123	UTSW	7	20,896,794 (GRCm39)	missense	probably benign
R9271:Vmn1r123	UTSW	7	20,896,794 (GRCm39)	missense	probably benign
R9544:Vmn1r123	UTSW	7	20,896,987 (GRCm39)	missense	probably benign	0.30
R9779:Vmn1r123	UTSW	7	20,896,111 (GRCm39)	start codon destroyed	probably null	0.99

Posted On

2015-04-16