Incidental Mutation 'IGL00942:H3c1'
ID 28863
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol H3c1
Ensembl Gene ENSMUSG00000069265
Gene Name H3 clustered histone 1
Synonyms Hist1h3a
Accession Numbers
Essential gene? Not available question?
Stock # IGL00942
Quality Score
Status
Chromosome 13
Chromosomal Location 23945868-23946369 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 23945921 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000100030 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055770] [ENSMUST00000091701] [ENSMUST00000102964] [ENSMUST00000102965]
AlphaFold P68433
Predicted Effect probably benign
Transcript: ENSMUST00000055770
SMART Domains Protein: ENSMUSP00000062030
Gene: ENSMUSG00000049539

DomainStartEndE-ValueType
H15 36 101 3.22e-22 SMART
low complexity region 120 213 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000091701
SMART Domains Protein: ENSMUSP00000089293
Gene: ENSMUSG00000069265

DomainStartEndE-ValueType
H3 34 136 1.5e-75 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102964
SMART Domains Protein: ENSMUSP00000100029
Gene: ENSMUSG00000060093

DomainStartEndE-ValueType
H4 16 90 2.59e-29 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102965
SMART Domains Protein: ENSMUSP00000100030
Gene: ENSMUSG00000069266

DomainStartEndE-ValueType
H4 16 90 2.59e-29 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139822
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arap2 A C 5: 62,855,732 (GRCm39) L568* probably null Het
Arfgef2 G A 2: 166,727,773 (GRCm39) V1574M probably damaging Het
Arhgef12 C T 9: 42,893,296 (GRCm39) R969H probably damaging Het
Cacng1 A T 11: 107,595,195 (GRCm39) F127L probably benign Het
Cntnap5c T C 17: 58,076,593 (GRCm39) V10A probably benign Het
Crtac1 T G 19: 42,312,233 (GRCm39) D160A probably damaging Het
Csmd3 C T 15: 47,710,502 (GRCm39) probably null Het
Grin3a A G 4: 49,770,589 (GRCm39) F728L probably damaging Het
Hecw1 C T 13: 14,515,325 (GRCm39) probably benign Het
Iyd C T 10: 3,554,070 (GRCm38) C239F probably damaging Het
Madd A G 2: 91,000,923 (GRCm39) V486A probably damaging Het
Map3k7 A G 4: 32,019,539 (GRCm39) D533G probably damaging Het
Matk A G 10: 81,094,128 (GRCm39) D20G probably benign Het
Mphosph10 A G 7: 64,039,503 (GRCm39) S156P probably benign Het
Mtif2 G A 11: 29,488,753 (GRCm39) E356K probably damaging Het
Ndufb10 T C 17: 24,943,158 (GRCm39) probably null Het
Nipal3 A T 4: 135,195,904 (GRCm39) L233Q possibly damaging Het
Or7e169 T C 9: 19,757,555 (GRCm39) Y120C probably damaging Het
Prss32 T A 17: 24,078,134 (GRCm39) C273* probably null Het
Prtg T C 9: 72,799,622 (GRCm39) S807P possibly damaging Het
Ric3 T G 7: 108,653,619 (GRCm39) E157D probably damaging Het
Ric3 T A 7: 108,653,620 (GRCm39) E157V probably damaging Het
Slc16a14 G A 1: 84,900,592 (GRCm39) T131I probably damaging Het
Slc1a2 A T 2: 102,570,159 (GRCm39) N137Y probably damaging Het
Slc25a27 T C 17: 43,974,980 (GRCm39) I94V probably benign Het
Slco1a1 G A 6: 141,892,354 (GRCm39) T4I probably benign Het
Slf1 A T 13: 77,192,066 (GRCm39) F923I possibly damaging Het
Taf7l2 A G 10: 115,949,341 (GRCm39) S62P possibly damaging Het
Ttll12 A C 15: 83,466,649 (GRCm39) V306G possibly damaging Het
Tulp2 G A 7: 45,165,692 (GRCm39) V97I possibly damaging Het
Vmn2r65 T G 7: 84,592,761 (GRCm39) Q482P probably damaging Het
Wdr24 T A 17: 26,045,595 (GRCm39) N443K probably benign Het
Other mutations in H3c1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00949:H3c1 APN 13 23,946,014 (GRCm39) missense probably damaging 1.00
IGL02630:H3c1 APN 13 23,946,231 (GRCm39) missense probably benign 0.07
IGL03252:H3c1 APN 13 23,945,943 (GRCm39) splice site probably null
R1709:H3c1 UTSW 13 23,945,964 (GRCm39) missense probably damaging 0.98
R8356:H3c1 UTSW 13 23,946,083 (GRCm39) missense probably damaging 0.99
R8456:H3c1 UTSW 13 23,946,083 (GRCm39) missense probably damaging 0.99
Z1177:H3c1 UTSW 13 23,946,233 (GRCm39) missense possibly damaging 0.70
Z1177:H3c1 UTSW 13 23,946,005 (GRCm39) missense probably damaging 1.00
Posted On 2013-04-17