Incidental Mutation 'IGL02337:Vmn1r73'
| ID |
288895 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r73
|
| Ensembl Gene |
ENSMUSG00000051687 |
| Gene Name |
vomeronasal 1 receptor 73 |
| Synonyms |
V1rg2 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.049)
|
| Stock # |
IGL02337
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
11490184-11491095 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 11490640 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Threonine
at position 153
(P153T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153827
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055070]
[ENSMUST00000226516]
|
| AlphaFold |
Q8R293 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000055070
AA Change: P153T
PolyPhen 2
Score 0.693 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000055353
Gene: ENSMUSG00000051687
AA Change: P153T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
301 |
7.5e-7 |
PFAM |
|
Pfam:V1R
|
32 |
297 |
1.9e-27 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226516
AA Change: P153T
PolyPhen 2
Score 0.693 (Sensitivity: 0.86; Specificity: 0.92)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aaas |
A |
G |
15: 102,247,662 (GRCm39) |
V403A |
probably benign |
Het |
| Afm |
A |
G |
5: 90,695,770 (GRCm39) |
T426A |
probably benign |
Het |
| Atp8a2 |
T |
C |
14: 60,235,451 (GRCm39) |
D697G |
probably benign |
Het |
| Barhl1 |
G |
T |
2: 28,801,431 (GRCm39) |
S204R |
probably damaging |
Het |
| Ceacam11 |
T |
A |
7: 17,707,550 (GRCm39) |
S111R |
probably benign |
Het |
| Cenpe |
A |
G |
3: 134,926,037 (GRCm39) |
|
probably benign |
Het |
| Cnot11 |
G |
A |
1: 39,583,964 (GRCm39) |
|
probably benign |
Het |
| Ctc1 |
A |
G |
11: 68,916,957 (GRCm39) |
T284A |
probably damaging |
Het |
| Ephb3 |
A |
G |
16: 21,040,253 (GRCm39) |
|
probably null |
Het |
| Fsip1 |
T |
A |
2: 118,082,195 (GRCm39) |
K80* |
probably null |
Het |
| Gaa |
G |
T |
11: 119,168,429 (GRCm39) |
G220C |
probably damaging |
Het |
| Gna15 |
T |
C |
10: 81,350,244 (GRCm39) |
S53G |
probably damaging |
Het |
| Hfm1 |
A |
T |
5: 107,052,133 (GRCm39) |
M321K |
possibly damaging |
Het |
| Hgfac |
C |
A |
5: 35,199,722 (GRCm39) |
T68K |
probably benign |
Het |
| Hmgxb4 |
C |
T |
8: 75,726,259 (GRCm39) |
R35W |
probably damaging |
Het |
| Itfg2 |
T |
C |
6: 128,390,533 (GRCm39) |
D184G |
probably benign |
Het |
| Kirrel1 |
G |
A |
3: 86,996,519 (GRCm39) |
T360I |
possibly damaging |
Het |
| Lrp1 |
T |
C |
10: 127,412,756 (GRCm39) |
Q1240R |
possibly damaging |
Het |
| Lrrk1 |
G |
T |
7: 65,929,164 (GRCm39) |
T1156N |
possibly damaging |
Het |
| Olfm1 |
A |
G |
2: 28,119,697 (GRCm39) |
Y429C |
probably damaging |
Het |
| Or4k77 |
T |
G |
2: 111,199,496 (GRCm39) |
V173G |
probably benign |
Het |
| Or5t5 |
T |
A |
2: 86,616,518 (GRCm39) |
M148K |
probably damaging |
Het |
| Pafah1b2 |
C |
T |
9: 45,884,287 (GRCm39) |
V122I |
probably benign |
Het |
| Pdcd1 |
T |
C |
1: 93,968,582 (GRCm39) |
T151A |
probably benign |
Het |
| Pkd1l1 |
T |
C |
11: 8,892,079 (GRCm39) |
S697G |
probably damaging |
Het |
| Rgs12 |
T |
A |
5: 35,177,697 (GRCm39) |
F96I |
probably damaging |
Het |
| Sptbn4 |
T |
C |
7: 27,127,672 (GRCm39) |
D176G |
probably benign |
Het |
| Tarbp2 |
C |
A |
15: 102,430,428 (GRCm39) |
Q148K |
probably damaging |
Het |
| Txk |
T |
C |
5: 72,864,889 (GRCm39) |
R329G |
possibly damaging |
Het |
| Unc79 |
T |
A |
12: 103,122,705 (GRCm39) |
|
probably benign |
Het |
| Zeb2 |
G |
A |
2: 44,887,242 (GRCm39) |
T605I |
probably damaging |
Het |
| Zfp654 |
A |
G |
16: 64,605,512 (GRCm39) |
S897P |
probably benign |
Het |
|
| Other mutations in Vmn1r73 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01782:Vmn1r73
|
APN |
7 |
11,490,665 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02666:Vmn1r73
|
APN |
7 |
11,490,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02741:Vmn1r73
|
APN |
7 |
11,490,710 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02756:Vmn1r73
|
APN |
7 |
11,490,574 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03113:Vmn1r73
|
APN |
7 |
11,490,527 (GRCm39) |
missense |
probably benign |
|
|
IGL03195:Vmn1r73
|
APN |
7 |
11,491,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0023:Vmn1r73
|
UTSW |
7 |
11,490,997 (GRCm39) |
missense |
probably benign |
0.43 |
|
R0379:Vmn1r73
|
UTSW |
7 |
11,490,773 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3941:Vmn1r73
|
UTSW |
7 |
11,490,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4224:Vmn1r73
|
UTSW |
7 |
11,490,506 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4631:Vmn1r73
|
UTSW |
7 |
11,490,758 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4912:Vmn1r73
|
UTSW |
7 |
11,490,596 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5060:Vmn1r73
|
UTSW |
7 |
11,490,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5450:Vmn1r73
|
UTSW |
7 |
11,490,376 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5609:Vmn1r73
|
UTSW |
7 |
11,490,591 (GRCm39) |
nonsense |
probably null |
|
|
R6059:Vmn1r73
|
UTSW |
7 |
11,490,538 (GRCm39) |
missense |
probably benign |
0.40 |
|
R6508:Vmn1r73
|
UTSW |
7 |
11,490,631 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6967:Vmn1r73
|
UTSW |
7 |
11,490,544 (GRCm39) |
nonsense |
probably null |
|
|
R7099:Vmn1r73
|
UTSW |
7 |
11,490,320 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7304:Vmn1r73
|
UTSW |
7 |
11,490,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7579:Vmn1r73
|
UTSW |
7 |
11,491,082 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7891:Vmn1r73
|
UTSW |
7 |
11,491,036 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8914:Vmn1r73
|
UTSW |
7 |
11,490,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9072:Vmn1r73
|
UTSW |
7 |
11,490,203 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9073:Vmn1r73
|
UTSW |
7 |
11,490,203 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9275:Vmn1r73
|
UTSW |
7 |
11,490,479 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9632:Vmn1r73
|
UTSW |
7 |
11,490,407 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9710:Vmn1r73
|
UTSW |
7 |
11,490,407 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
Z1176:Vmn1r73
|
UTSW |
7 |
11,490,883 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Posted On |
2015-04-16 |
Incidental Mutation