Incidental Mutation 'IGL02337:Gna15'
ID 288900
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gna15
Ensembl Gene ENSMUSG00000034792
Gene Name guanine nucleotide binding protein, alpha 15
Synonyms Galpha15, G[a]15
Accession Numbers
Essential gene? Probably non essential (E-score: 0.211) question?
Stock # IGL02337
Quality Score
Status
Chromosome 10
Chromosomal Location 81338140-81360059 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 81350244 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 53 (S53G)
Ref Sequence ENSEMBL: ENSMUSP00000049175 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043709]
AlphaFold P30678
Predicted Effect probably damaging
Transcript: ENSMUST00000043709
AA Change: S53G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000049175
Gene: ENSMUSG00000034792
AA Change: S53G

DomainStartEndE-ValueType
G_alpha 22 373 1.22e-188 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150586
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null mutation exhibit normal hematopoiesis and normal response to inflammatory challenges. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aaas A G 15: 102,247,662 (GRCm39) V403A probably benign Het
Afm A G 5: 90,695,770 (GRCm39) T426A probably benign Het
Atp8a2 T C 14: 60,235,451 (GRCm39) D697G probably benign Het
Barhl1 G T 2: 28,801,431 (GRCm39) S204R probably damaging Het
Ceacam11 T A 7: 17,707,550 (GRCm39) S111R probably benign Het
Cenpe A G 3: 134,926,037 (GRCm39) probably benign Het
Cnot11 G A 1: 39,583,964 (GRCm39) probably benign Het
Ctc1 A G 11: 68,916,957 (GRCm39) T284A probably damaging Het
Ephb3 A G 16: 21,040,253 (GRCm39) probably null Het
Fsip1 T A 2: 118,082,195 (GRCm39) K80* probably null Het
Gaa G T 11: 119,168,429 (GRCm39) G220C probably damaging Het
Hfm1 A T 5: 107,052,133 (GRCm39) M321K possibly damaging Het
Hgfac C A 5: 35,199,722 (GRCm39) T68K probably benign Het
Hmgxb4 C T 8: 75,726,259 (GRCm39) R35W probably damaging Het
Itfg2 T C 6: 128,390,533 (GRCm39) D184G probably benign Het
Kirrel1 G A 3: 86,996,519 (GRCm39) T360I possibly damaging Het
Lrp1 T C 10: 127,412,756 (GRCm39) Q1240R possibly damaging Het
Lrrk1 G T 7: 65,929,164 (GRCm39) T1156N possibly damaging Het
Olfm1 A G 2: 28,119,697 (GRCm39) Y429C probably damaging Het
Or4k77 T G 2: 111,199,496 (GRCm39) V173G probably benign Het
Or5t5 T A 2: 86,616,518 (GRCm39) M148K probably damaging Het
Pafah1b2 C T 9: 45,884,287 (GRCm39) V122I probably benign Het
Pdcd1 T C 1: 93,968,582 (GRCm39) T151A probably benign Het
Pkd1l1 T C 11: 8,892,079 (GRCm39) S697G probably damaging Het
Rgs12 T A 5: 35,177,697 (GRCm39) F96I probably damaging Het
Sptbn4 T C 7: 27,127,672 (GRCm39) D176G probably benign Het
Tarbp2 C A 15: 102,430,428 (GRCm39) Q148K probably damaging Het
Txk T C 5: 72,864,889 (GRCm39) R329G possibly damaging Het
Unc79 T A 12: 103,122,705 (GRCm39) probably benign Het
Vmn1r73 C A 7: 11,490,640 (GRCm39) P153T possibly damaging Het
Zeb2 G A 2: 44,887,242 (GRCm39) T605I probably damaging Het
Zfp654 A G 16: 64,605,512 (GRCm39) S897P probably benign Het
Other mutations in Gna15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03346:Gna15 APN 10 81,338,879 (GRCm39) missense probably damaging 0.99
R0062:Gna15 UTSW 10 81,348,239 (GRCm39) splice site probably null
R0062:Gna15 UTSW 10 81,348,239 (GRCm39) splice site probably null
R0464:Gna15 UTSW 10 81,348,338 (GRCm39) missense probably benign 0.15
R0732:Gna15 UTSW 10 81,348,390 (GRCm39) missense probably damaging 0.97
R1529:Gna15 UTSW 10 81,345,176 (GRCm39) missense probably damaging 1.00
R1768:Gna15 UTSW 10 81,347,954 (GRCm39) missense probably damaging 1.00
R2151:Gna15 UTSW 10 81,338,738 (GRCm39) missense probably damaging 1.00
R2153:Gna15 UTSW 10 81,338,738 (GRCm39) missense probably damaging 1.00
R5575:Gna15 UTSW 10 81,359,707 (GRCm39) missense probably damaging 1.00
R5750:Gna15 UTSW 10 81,345,230 (GRCm39) nonsense probably null
R5790:Gna15 UTSW 10 81,345,218 (GRCm39) missense probably damaging 1.00
R6123:Gna15 UTSW 10 81,345,178 (GRCm39) missense probably damaging 1.00
R6222:Gna15 UTSW 10 81,347,880 (GRCm39) missense probably damaging 1.00
R6750:Gna15 UTSW 10 81,350,117 (GRCm39) missense probably benign
R7138:Gna15 UTSW 10 81,343,881 (GRCm39) missense probably damaging 1.00
R7426:Gna15 UTSW 10 81,338,831 (GRCm39) missense probably benign 0.03
R7542:Gna15 UTSW 10 81,350,136 (GRCm39) missense probably damaging 1.00
R7802:Gna15 UTSW 10 81,350,175 (GRCm39) missense probably benign 0.28
R7942:Gna15 UTSW 10 81,359,745 (GRCm39) missense probably damaging 0.98
R9168:Gna15 UTSW 10 81,350,192 (GRCm39) missense probably damaging 1.00
R9188:Gna15 UTSW 10 81,343,798 (GRCm39) missense probably benign 0.43
R9206:Gna15 UTSW 10 81,345,224 (GRCm39) missense probably benign 0.25
R9208:Gna15 UTSW 10 81,345,224 (GRCm39) missense probably benign 0.25
R9237:Gna15 UTSW 10 81,359,683 (GRCm39) missense possibly damaging 0.83
R9695:Gna15 UTSW 10 81,359,752 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16