Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02337:Cnot11'

288913

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cnot11

Ensembl Gene

ENSMUSG00000003135

Gene Name

CCR4-NOT transcription complex, subunit 11

Synonyms

2410015L18Rik, D1Bwg0212e

Accession Numbers

Essential gene?

Probably essential (E-score: 0.952) question?

Stock #

IGL02337

Quality Score

Status

Chromosome

Chromosomal Location

39574782-39585962 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to A at 39583964 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000141388 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000003219] [ENSMUST00000161515] [ENSMUST00000195567]

AlphaFold

Q9CWN7

Predicted Effect

probably benign
Transcript: ENSMUST00000003219

SMART Domains

Protein: ENSMUSP00000003219
Gene: ENSMUSG00000003135

Domain	Start	End	E-Value	Type
low complexity region	25	55	N/A	INTRINSIC
low complexity region	62	73	N/A	INTRINSIC
low complexity region	234	257	N/A	INTRINSIC
Pfam:DUF2363	366	490	1.7e-58	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000104516

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146314

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160145

Predicted Effect

probably benign
Transcript: ENSMUST00000161515

SMART Domains

Protein: ENSMUSP00000125638
Gene: ENSMUSG00000003135

Domain	Start	End	E-Value	Type
low complexity region	25	55	N/A	INTRINSIC
low complexity region	62	73	N/A	INTRINSIC
low complexity region	234	257	N/A	INTRINSIC
Pfam:DUF2363	366	491	3.3e-57	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000195567

SMART Domains

Protein: ENSMUSP00000141388
Gene: ENSMUSG00000003135

Domain	Start	End	E-Value	Type
Pfam:DUF2363	40	148	3.4e-44	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aaas	A	G	15: 102,247,662 (GRCm39)	V403A	probably benign	Het
Afm	A	G	5: 90,695,770 (GRCm39)	T426A	probably benign	Het
Atp8a2	T	C	14: 60,235,451 (GRCm39)	D697G	probably benign	Het
Barhl1	G	T	2: 28,801,431 (GRCm39)	S204R	probably damaging	Het
Ceacam11	T	A	7: 17,707,550 (GRCm39)	S111R	probably benign	Het
Cenpe	A	G	3: 134,926,037 (GRCm39)		probably benign	Het
Ctc1	A	G	11: 68,916,957 (GRCm39)	T284A	probably damaging	Het
Ephb3	A	G	16: 21,040,253 (GRCm39)		probably null	Het
Fsip1	T	A	2: 118,082,195 (GRCm39)	K80*	probably null	Het
Gaa	G	T	11: 119,168,429 (GRCm39)	G220C	probably damaging	Het
Gna15	T	C	10: 81,350,244 (GRCm39)	S53G	probably damaging	Het
Hfm1	A	T	5: 107,052,133 (GRCm39)	M321K	possibly damaging	Het
Hgfac	C	A	5: 35,199,722 (GRCm39)	T68K	probably benign	Het
Hmgxb4	C	T	8: 75,726,259 (GRCm39)	R35W	probably damaging	Het
Itfg2	T	C	6: 128,390,533 (GRCm39)	D184G	probably benign	Het
Kirrel1	G	A	3: 86,996,519 (GRCm39)	T360I	possibly damaging	Het
Lrp1	T	C	10: 127,412,756 (GRCm39)	Q1240R	possibly damaging	Het
Lrrk1	G	T	7: 65,929,164 (GRCm39)	T1156N	possibly damaging	Het
Olfm1	A	G	2: 28,119,697 (GRCm39)	Y429C	probably damaging	Het
Or4k77	T	G	2: 111,199,496 (GRCm39)	V173G	probably benign	Het
Or5t5	T	A	2: 86,616,518 (GRCm39)	M148K	probably damaging	Het
Pafah1b2	C	T	9: 45,884,287 (GRCm39)	V122I	probably benign	Het
Pdcd1	T	C	1: 93,968,582 (GRCm39)	T151A	probably benign	Het
Pkd1l1	T	C	11: 8,892,079 (GRCm39)	S697G	probably damaging	Het
Rgs12	T	A	5: 35,177,697 (GRCm39)	F96I	probably damaging	Het
Sptbn4	T	C	7: 27,127,672 (GRCm39)	D176G	probably benign	Het
Tarbp2	C	A	15: 102,430,428 (GRCm39)	Q148K	probably damaging	Het
Txk	T	C	5: 72,864,889 (GRCm39)	R329G	possibly damaging	Het
Unc79	T	A	12: 103,122,705 (GRCm39)		probably benign	Het
Vmn1r73	C	A	7: 11,490,640 (GRCm39)	P153T	possibly damaging	Het
Zeb2	G	A	2: 44,887,242 (GRCm39)	T605I	probably damaging	Het
Zfp654	A	G	16: 64,605,512 (GRCm39)	S897P	probably benign	Het

Other mutations in Cnot11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1087:Cnot11	UTSW	1	39,579,139 (GRCm39)	missense	probably benign	0.18
R1398:Cnot11	UTSW	1	39,584,261 (GRCm39)	missense	probably damaging	0.99
R3433:Cnot11	UTSW	1	39,584,268 (GRCm39)	splice site	probably null
R4134:Cnot11	UTSW	1	39,576,629 (GRCm39)	missense	probably benign	0.11
R4633:Cnot11	UTSW	1	39,575,299 (GRCm39)	missense	probably benign	0.00
R5856:Cnot11	UTSW	1	39,576,534 (GRCm39)	missense	probably benign	0.06
R6841:Cnot11	UTSW	1	39,579,148 (GRCm39)	nonsense	probably null
R6931:Cnot11	UTSW	1	39,579,002 (GRCm39)	missense	probably damaging	0.99
R7290:Cnot11	UTSW	1	39,579,020 (GRCm39)	nonsense	probably null
R9251:Cnot11	UTSW	1	39,581,587 (GRCm39)	missense	probably damaging	0.98
R9508:Cnot11	UTSW	1	39,581,575 (GRCm39)	missense	probably damaging	0.99
RF007:Cnot11	UTSW	1	39,581,575 (GRCm39)	missense	probably damaging	0.99
Z1177:Cnot11	UTSW	1	39,574,929 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16