Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02338:Or1j19'

288926

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or1j19

Ensembl Gene

ENSMUSG00000049315

Gene Name

olfactory receptor family 1 subfamily J member 19

Synonyms

GA_x6K02T2NLDC-33481050-33481991, Olfr348, MOR136-8

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL02338

Quality Score

Status

Chromosome

Chromosomal Location

36676539-36677480 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 36676557 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 7 (Q7*)

Ref Sequence

ENSEMBL: ENSMUSP00000150343 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056865] [ENSMUST00000112950] [ENSMUST00000213498] [ENSMUST00000214909] [ENSMUST00000215199] [ENSMUST00000216753] [ENSMUST00000217041]

AlphaFold

Q8VGK3

Predicted Effect

probably null
Transcript: ENSMUST00000056865
AA Change: Q7*

SMART Domains

Protein: ENSMUSP00000054037
Gene: ENSMUSG00000049315
AA Change: Q7*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	309	1.3e-56	PFAM
Pfam:7TM_GPCR_Srsx	36	306	3e-6	PFAM
Pfam:7tm_1	42	291	2.7e-24	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000112950
AA Change: Q7*

SMART Domains

Protein: ENSMUSP00000108572
Gene: ENSMUSG00000111021
AA Change: Q7*

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	36	306	3e-6	PFAM
Pfam:7tm_1	42	291	3.5e-34	PFAM
Pfam:7tm_4	140	284	3.9e-40	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000213498
AA Change: Q7*

Predicted Effect

probably null
Transcript: ENSMUST00000214909
AA Change: Q7*

Predicted Effect

probably null
Transcript: ENSMUST00000215199
AA Change: Q7*

Predicted Effect

probably benign
Transcript: ENSMUST00000216753

Predicted Effect

probably benign
Transcript: ENSMUST00000217041

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahdc1	G	A	4: 132,789,860 (GRCm39)	C367Y	possibly damaging	Het
AI182371	T	A	2: 34,975,728 (GRCm39)	I279L	probably benign	Het
Ambp	A	T	4: 63,061,934 (GRCm39)	C332S	probably damaging	Het
App	T	C	16: 84,970,407 (GRCm39)	T14A	probably benign	Het
Asap1	A	T	15: 63,995,519 (GRCm39)		probably null	Het
Aurka	T	C	2: 172,201,778 (GRCm39)	R242G	probably benign	Het
BC034090	G	A	1: 155,093,217 (GRCm39)	P747L	probably damaging	Het
Bcl6b	T	C	11: 70,119,918 (GRCm39)	D23G	probably damaging	Het
Cabp2	A	C	19: 4,134,154 (GRCm39)	E42A	possibly damaging	Het
Ccdc14	G	A	16: 34,542,173 (GRCm39)	S557N	probably benign	Het
Ccdc146	G	T	5: 21,524,604 (GRCm39)		probably benign	Het
Cenpf	T	A	1: 189,412,615 (GRCm39)	Q216L	probably damaging	Het
Ces1b	G	A	8: 93,783,675 (GRCm39)	P515L	possibly damaging	Het
Col6a5	A	T	9: 105,755,829 (GRCm39)	N2198K	probably damaging	Het
Csmd2	A	G	4: 128,288,859 (GRCm39)	S1133G	possibly damaging	Het
Cspg5	G	A	9: 110,085,335 (GRCm39)	R502H	probably benign	Het
Cyp2g1	A	G	7: 26,514,229 (GRCm39)		probably benign	Het
Dnajc27	A	G	12: 4,146,229 (GRCm39)	Y86C	probably damaging	Het
Dnm1	T	C	2: 32,202,783 (GRCm39)	D715G	probably damaging	Het
Dock1	G	T	7: 134,734,804 (GRCm39)	L1317F	possibly damaging	Het
Fanci	T	A	7: 79,083,279 (GRCm39)	Y727*	probably null	Het
Fbxw20	T	A	9: 109,055,046 (GRCm39)	T168S	probably benign	Het
Folh1	A	T	7: 86,385,723 (GRCm39)		probably benign	Het
Gas7	A	T	11: 67,573,557 (GRCm39)	S379C	probably damaging	Het
Gbp2b	A	G	3: 142,309,987 (GRCm39)	E259G	probably benign	Het
Gm8325	T	C	3: 60,784,805 (GRCm39)		noncoding transcript	Het
Gpr75	A	T	11: 30,841,730 (GRCm39)	T212S	probably benign	Het
Itgb4	A	G	11: 115,898,795 (GRCm39)	T1711A	probably damaging	Het
Ly75	T	C	2: 60,184,796 (GRCm39)	S453G	probably benign	Het
Maneal	A	G	4: 124,754,276 (GRCm39)		probably benign	Het
Marco	A	T	1: 120,422,508 (GRCm39)	I58N	possibly damaging	Het
Mtcl1	A	G	17: 66,686,965 (GRCm39)	I647T	probably damaging	Het
Mtfr1l	A	T	4: 134,258,054 (GRCm39)	V56D	probably damaging	Het
Npy1r	G	A	8: 67,156,954 (GRCm39)	V125I	probably damaging	Het
Or52n20	T	C	7: 104,320,888 (GRCm39)		probably benign	Het
Or7g25	A	G	9: 19,159,960 (GRCm39)	L245P	probably damaging	Het
Osmr	A	T	15: 6,867,210 (GRCm39)	L362*	probably null	Het
Pdlim2	T	C	14: 70,411,906 (GRCm39)	D42G	probably damaging	Het
Plcb4	T	A	2: 135,842,100 (GRCm39)	I89N	possibly damaging	Het
Prrc2b	T	A	2: 32,104,047 (GRCm39)	M1175K	probably benign	Het
Pzp	T	A	6: 128,463,133 (GRCm39)	N1423I	probably benign	Het
Retnla	G	A	16: 48,664,561 (GRCm39)	C105Y	probably damaging	Het
Samd8	T	A	14: 21,825,544 (GRCm39)	S167T	possibly damaging	Het
Scg2	A	G	1: 79,414,210 (GRCm39)	M171T	possibly damaging	Het
Slc30a5	A	G	13: 100,939,941 (GRCm39)	V658A	probably damaging	Het
Slc41a2	T	C	10: 83,152,455 (GRCm39)	R7G	possibly damaging	Het
Slc44a2	A	G	9: 21,258,338 (GRCm39)	T500A	probably damaging	Het
Slc44a4	G	T	17: 35,142,786 (GRCm39)	G396V	possibly damaging	Het
Smarca5	A	G	8: 81,446,199 (GRCm39)		probably benign	Het
St8sia6	T	A	2: 13,798,156 (GRCm39)	R34W	probably damaging	Het
Stk-ps2	T	A	1: 46,069,337 (GRCm39)		noncoding transcript	Het
Stn1	T	C	19: 47,502,329 (GRCm39)	Y235C	probably damaging	Het
Tbx15	A	G	3: 99,259,800 (GRCm39)	Y557C	probably damaging	Het
Tgfbr1	G	A	4: 47,393,490 (GRCm39)		probably null	Het
Thsd7b	G	T	1: 129,523,508 (GRCm39)	V181L	probably damaging	Het
Tmpo	G	A	10: 90,999,104 (GRCm39)	R228C	probably benign	Het
Trpm4	T	G	7: 44,976,422 (GRCm39)	R51S	probably damaging	Het
Vmn1r91	A	T	7: 19,835,671 (GRCm39)	T197S	probably damaging	Het
Vmn2r-ps158	T	C	7: 42,697,160 (GRCm39)	I739T	probably damaging	Het
Xrn1	A	G	9: 95,859,880 (GRCm39)	D424G	probably benign	Het
Yap1	A	G	9: 7,962,282 (GRCm39)		probably null	Het
Zer1	T	C	2: 30,003,405 (GRCm39)	D4G	probably damaging	Het
Zfp462	A	T	4: 55,010,292 (GRCm39)	I753F	possibly damaging	Het

Other mutations in Or1j19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01388:Or1j19	APN	2	36,677,367 (GRCm39)	missense	probably benign	0.03
IGL01943:Or1j19	APN	2	36,677,095 (GRCm39)	missense	probably benign	0.13
IGL02030:Or1j19	APN	2	36,677,410 (GRCm39)	missense	probably damaging	1.00
IGL02349:Or1j19	APN	2	36,677,058 (GRCm39)	missense	possibly damaging	0.95
IGL02695:Or1j19	APN	2	36,677,332 (GRCm39)	missense	possibly damaging	0.72
IGL03004:Or1j19	APN	2	36,677,194 (GRCm39)	missense	probably damaging	1.00
IGL03007:Or1j19	APN	2	36,676,812 (GRCm39)	missense	probably damaging	0.99
IGL03024:Or1j19	APN	2	36,676,858 (GRCm39)	missense	possibly damaging	0.55
R0360:Or1j19	UTSW	2	36,677,452 (GRCm39)	missense	probably benign	0.03
R0388:Or1j19	UTSW	2	36,676,874 (GRCm39)	missense	probably benign	0.43
R0614:Or1j19	UTSW	2	36,676,705 (GRCm39)	missense	probably damaging	1.00
R1498:Or1j19	UTSW	2	36,677,358 (GRCm39)	missense	probably damaging	1.00
R1562:Or1j19	UTSW	2	36,676,696 (GRCm39)	missense	probably damaging	1.00
R2882:Or1j19	UTSW	2	36,677,202 (GRCm39)	missense	probably damaging	1.00
R3731:Or1j19	UTSW	2	36,676,578 (GRCm39)	missense	possibly damaging	0.53
R4513:Or1j19	UTSW	2	36,676,782 (GRCm39)	missense	probably benign	0.05
R4899:Or1j19	UTSW	2	36,676,810 (GRCm39)	missense	probably benign	0.04
R5005:Or1j19	UTSW	2	36,677,370 (GRCm39)	missense	probably benign
R5035:Or1j19	UTSW	2	36,676,903 (GRCm39)	missense	probably damaging	1.00
R5490:Or1j19	UTSW	2	36,677,193 (GRCm39)	missense	probably damaging	1.00
R6361:Or1j19	UTSW	2	36,676,792 (GRCm39)	missense	probably damaging	1.00
R7762:Or1j19	UTSW	2	36,677,022 (GRCm39)	missense	probably benign	0.03
R8109:Or1j19	UTSW	2	36,676,618 (GRCm39)	missense	probably benign	0.00
R8223:Or1j19	UTSW	2	36,677,409 (GRCm39)	missense
R8826:Or1j19	UTSW	2	36,676,855 (GRCm39)	nonsense	probably null
R8906:Or1j19	UTSW	2	36,676,621 (GRCm39)	missense	probably benign	0.01
R9138:Or1j19	UTSW	2	36,676,702 (GRCm39)	missense	probably benign	0.00
R9147:Or1j19	UTSW	2	36,676,938 (GRCm39)	missense	probably benign	0.01
R9148:Or1j19	UTSW	2	36,676,938 (GRCm39)	missense	probably benign	0.01
R9267:Or1j19	UTSW	2	36,676,530 (GRCm39)	unclassified	probably benign
R9306:Or1j19	UTSW	2	36,677,407 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16