Incidental Mutation 'IGL02340:Trhde'
ID 289058
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trhde
Ensembl Gene ENSMUSG00000050663
Gene Name TRH-degrading enzyme
Synonyms 9330155P21Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # IGL02340
Quality Score
Status
Chromosome 10
Chromosomal Location 114234725-114638207 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 114428118 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000057449 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061632]
AlphaFold Q8K093
Predicted Effect probably benign
Transcript: ENSMUST00000061632
SMART Domains Protein: ENSMUSP00000057449
Gene: ENSMUSG00000050663

DomainStartEndE-ValueType
transmembrane domain 40 62 N/A INTRINSIC
Pfam:Peptidase_M1 141 531 2.6e-141 PFAM
Pfam:ERAP1_C 679 1004 5.7e-65 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152702
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.[provided by RefSeq, Dec 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akt2 T A 7: 27,328,824 (GRCm39) I182N probably damaging Het
Alpk3 A G 7: 80,728,255 (GRCm39) T462A probably benign Het
Amz1 A G 5: 140,738,014 (GRCm39) R425G probably damaging Het
Aoc2 A G 11: 101,217,201 (GRCm39) E428G probably damaging Het
Car4 C T 11: 84,856,593 (GRCm39) P294S probably damaging Het
Chchd6 A T 6: 89,396,762 (GRCm39) H216Q probably damaging Het
Chl1 A G 6: 103,675,086 (GRCm39) Y591C probably damaging Het
Cln8 T C 8: 14,945,178 (GRCm39) L164S probably damaging Het
Dscaml1 T C 9: 45,581,474 (GRCm39) I431T possibly damaging Het
Fam234b T C 6: 135,208,659 (GRCm39) L524P probably damaging Het
Fmo1 T C 1: 162,660,559 (GRCm39) N410S probably benign Het
Ftsj3 G A 11: 106,143,972 (GRCm39) R251* probably null Het
Greb1l A T 18: 10,515,200 (GRCm39) D555V probably damaging Het
Hcar1 G T 5: 124,017,135 (GRCm39) H185Q probably damaging Het
Kcnj12 G A 11: 60,960,319 (GRCm39) V206I probably benign Het
Lamc3 G A 2: 31,808,469 (GRCm39) G742S probably damaging Het
Lipg T C 18: 75,093,946 (GRCm39) probably null Het
Ltbp2 A G 12: 84,839,729 (GRCm39) probably null Het
Mcm3ap T G 10: 76,332,386 (GRCm39) Y1234* probably null Het
Myh6 T A 14: 55,194,612 (GRCm39) D719V possibly damaging Het
Myo9b A G 8: 71,743,689 (GRCm39) N250S probably damaging Het
Nherf1 A G 11: 115,070,858 (GRCm39) E270G probably benign Het
Notch2 G A 3: 98,054,652 (GRCm39) W2438* probably null Het
Nphp1 G A 2: 127,621,987 (GRCm39) Q47* probably null Het
Nptx2 T C 5: 144,493,056 (GRCm39) L381P probably damaging Het
Nrxn3 A G 12: 90,171,402 (GRCm39) N911S possibly damaging Het
Or10j2 A T 1: 173,097,972 (GRCm39) I77F probably benign Het
Or5d46 T C 2: 88,169,906 (GRCm39) probably benign Het
P4ha1 T A 10: 59,188,023 (GRCm39) F260Y probably benign Het
Pitpnm2 T C 5: 124,268,676 (GRCm39) D504G probably damaging Het
Prss54 A G 8: 96,292,237 (GRCm39) V114A probably benign Het
Ptprc G A 1: 137,998,957 (GRCm39) T1031M probably damaging Het
Rtf2 T C 2: 172,310,511 (GRCm39) probably benign Het
Ryr3 A G 2: 112,777,349 (GRCm39) probably benign Het
Slc14a2 C T 18: 78,206,341 (GRCm39) E492K probably damaging Het
Stab1 G T 14: 30,862,367 (GRCm39) N2322K probably damaging Het
Thsd7b A G 1: 130,087,369 (GRCm39) N1162S probably benign Het
Tmprss11b T C 5: 86,810,090 (GRCm39) I297V probably benign Het
Tnn T C 1: 159,972,775 (GRCm39) N276D probably benign Het
Vmn1r115 T A 7: 20,578,453 (GRCm39) H153L possibly damaging Het
Vmn1r203 T A 13: 22,708,997 (GRCm39) C259* probably null Het
Xpot T A 10: 121,451,109 (GRCm39) E97V probably damaging Het
Zbtb2 T C 10: 4,318,712 (GRCm39) D438G probably damaging Het
Other mutations in Trhde
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00323:Trhde APN 10 114,322,652 (GRCm39) missense possibly damaging 0.77
IGL00516:Trhde APN 10 114,282,104 (GRCm39) missense probably benign 0.01
IGL01371:Trhde APN 10 114,424,405 (GRCm39) missense possibly damaging 0.57
IGL01488:Trhde APN 10 114,282,063 (GRCm39) missense possibly damaging 0.58
IGL01602:Trhde APN 10 114,623,848 (GRCm39) missense probably benign
IGL01605:Trhde APN 10 114,623,848 (GRCm39) missense probably benign
IGL02150:Trhde APN 10 114,428,013 (GRCm39) missense probably damaging 1.00
IGL02165:Trhde APN 10 114,428,066 (GRCm39) missense probably damaging 1.00
IGL02412:Trhde APN 10 114,322,830 (GRCm39) missense probably damaging 1.00
IGL02421:Trhde APN 10 114,248,366 (GRCm39) missense probably damaging 1.00
IGL02496:Trhde APN 10 114,636,466 (GRCm39) nonsense probably null
IGL02952:Trhde APN 10 114,636,478 (GRCm39) missense probably damaging 0.99
IGL03197:Trhde APN 10 114,249,213 (GRCm39) missense probably benign 0.00
Cata UTSW 10 114,427,971 (GRCm39) missense probably damaging 1.00
l3-37 UTSW 10 114,636,986 (GRCm39) missense probably benign
Pelte UTSW 10 114,322,609 (GRCm39) critical splice donor site probably null
G1Funyon:Trhde UTSW 10 114,322,911 (GRCm39) missense probably benign 0.03
R0360:Trhde UTSW 10 114,338,887 (GRCm39) splice site probably benign
R0364:Trhde UTSW 10 114,338,887 (GRCm39) splice site probably benign
R0457:Trhde UTSW 10 114,284,167 (GRCm39) missense probably benign 0.37
R0589:Trhde UTSW 10 114,284,229 (GRCm39) missense probably benign 0.01
R1132:Trhde UTSW 10 114,248,383 (GRCm39) missense possibly damaging 0.86
R1288:Trhde UTSW 10 114,637,195 (GRCm39) missense probably benign 0.37
R1569:Trhde UTSW 10 114,282,093 (GRCm39) missense possibly damaging 0.78
R1776:Trhde UTSW 10 114,636,508 (GRCm39) missense probably benign 0.06
R1781:Trhde UTSW 10 114,424,405 (GRCm39) missense possibly damaging 0.57
R1927:Trhde UTSW 10 114,636,754 (GRCm39) missense probably damaging 1.00
R1976:Trhde UTSW 10 114,424,336 (GRCm39) missense possibly damaging 0.57
R2011:Trhde UTSW 10 114,334,698 (GRCm39) missense probably benign 0.02
R2332:Trhde UTSW 10 114,428,070 (GRCm39) missense probably damaging 1.00
R2356:Trhde UTSW 10 114,237,421 (GRCm39) missense probably damaging 1.00
R3107:Trhde UTSW 10 114,427,971 (GRCm39) missense probably damaging 1.00
R3108:Trhde UTSW 10 114,427,971 (GRCm39) missense probably damaging 1.00
R3907:Trhde UTSW 10 114,636,601 (GRCm39) missense possibly damaging 0.72
R4067:Trhde UTSW 10 114,280,585 (GRCm39) nonsense probably null
R4214:Trhde UTSW 10 114,623,975 (GRCm39) missense possibly damaging 0.51
R4428:Trhde UTSW 10 114,339,028 (GRCm39) missense probably damaging 1.00
R4429:Trhde UTSW 10 114,339,028 (GRCm39) missense probably damaging 1.00
R4430:Trhde UTSW 10 114,339,028 (GRCm39) missense probably damaging 1.00
R5244:Trhde UTSW 10 114,636,986 (GRCm39) missense probably benign
R5456:Trhde UTSW 10 114,322,665 (GRCm39) missense possibly damaging 0.58
R5540:Trhde UTSW 10 114,636,497 (GRCm39) missense probably benign 0.45
R5699:Trhde UTSW 10 114,424,407 (GRCm39) missense probably benign 0.00
R5967:Trhde UTSW 10 114,403,039 (GRCm39) missense probably damaging 1.00
R6326:Trhde UTSW 10 114,403,129 (GRCm39) missense probably damaging 1.00
R6467:Trhde UTSW 10 114,340,103 (GRCm39) missense probably damaging 1.00
R7028:Trhde UTSW 10 114,354,082 (GRCm39) missense probably damaging 1.00
R7264:Trhde UTSW 10 114,636,776 (GRCm39) missense possibly damaging 0.93
R7266:Trhde UTSW 10 114,636,776 (GRCm39) missense possibly damaging 0.93
R7310:Trhde UTSW 10 114,636,478 (GRCm39) missense probably damaging 0.99
R7460:Trhde UTSW 10 114,249,168 (GRCm39) missense probably damaging 1.00
R7732:Trhde UTSW 10 114,623,969 (GRCm39) missense probably benign
R7842:Trhde UTSW 10 114,532,003 (GRCm39) missense possibly damaging 0.86
R8178:Trhde UTSW 10 114,244,598 (GRCm39) missense possibly damaging 0.93
R8209:Trhde UTSW 10 114,403,133 (GRCm39) missense probably damaging 1.00
R8226:Trhde UTSW 10 114,403,133 (GRCm39) missense probably damaging 1.00
R8232:Trhde UTSW 10 114,636,442 (GRCm39) missense possibly damaging 0.90
R8301:Trhde UTSW 10 114,322,911 (GRCm39) missense probably benign 0.03
R8312:Trhde UTSW 10 114,249,192 (GRCm39) missense probably damaging 1.00
R8335:Trhde UTSW 10 114,322,609 (GRCm39) critical splice donor site probably null
R8477:Trhde UTSW 10 114,636,622 (GRCm39) missense probably benign 0.02
R8853:Trhde UTSW 10 114,636,830 (GRCm39) missense probably benign
R8953:Trhde UTSW 10 114,338,966 (GRCm39) missense probably damaging 0.98
R9375:Trhde UTSW 10 114,244,598 (GRCm39) missense probably damaging 0.99
R9477:Trhde UTSW 10 114,338,980 (GRCm39) missense probably benign 0.03
R9486:Trhde UTSW 10 114,532,014 (GRCm39) missense possibly damaging 0.89
R9502:Trhde UTSW 10 114,636,697 (GRCm39) missense probably damaging 1.00
Z1177:Trhde UTSW 10 114,284,294 (GRCm39) critical splice acceptor site probably null
Posted On 2015-04-16