Incidental Mutation 'IGL02341:Ccnk'
ID289084
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccnk
Ensembl Gene ENSMUSG00000021258
Gene Namecyclin K
SynonymsCycK, CPR4
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL02341
Quality Score
Status
Chromosome12
Chromosomal Location108179579-108203359 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 108195730 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 298 (E298G)
Ref Sequence ENSEMBL: ENSMUSP00000152784 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000101055] [ENSMUST00000221167]
Predicted Effect unknown
Transcript: ENSMUST00000101055
AA Change: E298G
SMART Domains Protein: ENSMUSP00000098616
Gene: ENSMUSG00000021258
AA Change: E298G

DomainStartEndE-ValueType
CYCLIN 55 149 6.67e-16 SMART
Cyclin_C 158 278 4.83e-1 SMART
CYCLIN 162 256 1.23e-1 SMART
low complexity region 342 361 N/A INTRINSIC
low complexity region 365 392 N/A INTRINSIC
low complexity region 404 427 N/A INTRINSIC
low complexity region 428 446 N/A INTRINSIC
low complexity region 457 471 N/A INTRINSIC
low complexity region 476 576 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000221167
AA Change: E298G
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223363
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene trap allele display complete embryonic lethality before implantation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210407C18Rik T C 11: 58,612,830 S17G possibly damaging Het
Arid2 C T 15: 96,372,185 S1393L probably benign Het
Bahcc1 T A 11: 120,272,520 I548N probably damaging Het
Baiap3 A T 17: 25,248,316 L405Q possibly damaging Het
Cacna1g T G 11: 94,462,152 Q349P probably damaging Het
Ccdc30 T C 4: 119,356,781 T184A possibly damaging Het
Ccdc63 A G 5: 122,113,198 I383T probably benign Het
Ccnt1 T C 15: 98,546,783 E223G possibly damaging Het
Clcc1 T A 3: 108,673,383 L333I possibly damaging Het
Cyp2b10 G A 7: 25,911,242 R59Q probably benign Het
Cyp3a41b T A 5: 145,573,651 T138S probably benign Het
Dennd4a C T 9: 64,842,561 R145* probably null Het
Dnah8 A T 17: 30,747,257 I2474F probably damaging Het
Dok1 T C 6: 83,033,054 T25A probably damaging Het
Ears2 G A 7: 122,039,764 A479V probably benign Het
Erc1 T A 6: 119,594,973 I981F possibly damaging Het
Fam129c A T 8: 71,603,799 N381I possibly damaging Het
Gm8730 A G 8: 102,865,143 noncoding transcript Het
Gm9962 C T 7: 57,387,294 probably benign Het
Has3 A T 8: 106,874,005 Y33F probably damaging Het
Hk1 A G 10: 62,284,380 S607P possibly damaging Het
Hlcs T A 16: 94,231,110 I612F probably damaging Het
Llgl2 T A 11: 115,851,120 S663T possibly damaging Het
Lrriq1 T C 10: 103,224,941 H100R probably benign Het
Magi2 T A 5: 20,466,203 I678N probably damaging Het
Megf11 G A 9: 64,544,620 G109S probably damaging Het
Morc2b A T 17: 33,137,307 I497K probably damaging Het
Mybpc2 A C 7: 44,514,930 S404A probably benign Het
Mylip A G 13: 45,391,276 R59G probably damaging Het
Mylk3 A T 8: 85,351,972 I501N probably damaging Het
Myo19 A G 11: 84,888,045 probably benign Het
Nat2 A G 8: 67,501,718 Y160C possibly damaging Het
Nf1 C T 11: 79,564,926 A2554V probably benign Het
Ninl A T 2: 150,944,605 C153* probably null Het
Nlrp5 C T 7: 23,404,152 R15C probably benign Het
Nphp4 A T 4: 152,555,469 probably benign Het
Obscn C A 11: 59,135,825 R184L probably benign Het
Olfr767 A T 10: 129,079,461 C167* probably null Het
Olfr771 T A 10: 129,160,433 I184F probably benign Het
Olfr804 A T 10: 129,705,489 T204S probably damaging Het
Phip A T 9: 82,932,883 V262D probably damaging Het
Ptprg T A 14: 12,154,360 S694T probably benign Het
Reck T A 4: 43,925,160 D466E probably damaging Het
Rimbp2 G T 5: 128,800,961 Y213* probably null Het
Scn2a C T 2: 65,688,377 T365M probably damaging Het
Scpep1 T A 11: 88,944,488 T120S probably benign Het
Sp7 T A 15: 102,359,222 T50S possibly damaging Het
Tbc1d1 A G 5: 64,275,407 R304G probably damaging Het
Tiam1 A G 16: 89,898,369 S67P probably damaging Het
Tjp1 G A 7: 65,312,634 T1185I probably damaging Het
Tspan2 T A 3: 102,765,213 I178N probably damaging Het
Tusc2 T A 9: 107,564,910 *103R probably null Het
Uggt1 A T 1: 36,164,519 *47R probably null Het
Unc13c T A 9: 73,933,210 I120F possibly damaging Het
Vcpip1 T A 1: 9,724,950 K1065N possibly damaging Het
Zfp532 C A 18: 65,624,778 P594Q probably damaging Het
Other mutations in Ccnk
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02331:Ccnk APN 12 108189084 missense probably damaging 1.00
IGL02557:Ccnk APN 12 108195726 missense unknown
FR4449:Ccnk UTSW 12 108202507 unclassified probably benign
FR4737:Ccnk UTSW 12 108202507 unclassified probably benign
FR4976:Ccnk UTSW 12 108202507 unclassified probably benign
R0481:Ccnk UTSW 12 108199309 unclassified probably benign
R0725:Ccnk UTSW 12 108195575 splice site probably benign
R1839:Ccnk UTSW 12 108195074 missense probably damaging 1.00
R2144:Ccnk UTSW 12 108189090 missense probably null 1.00
R2903:Ccnk UTSW 12 108202388 unclassified probably benign
R4660:Ccnk UTSW 12 108202316 unclassified probably benign
R5131:Ccnk UTSW 12 108202631 unclassified probably benign
R5404:Ccnk UTSW 12 108195623 missense possibly damaging 0.88
R5843:Ccnk UTSW 12 108193730 missense probably damaging 1.00
R5860:Ccnk UTSW 12 108187207 missense probably damaging 0.99
R6522:Ccnk UTSW 12 108187187 missense probably damaging 0.99
R6864:Ccnk UTSW 12 108202214 unclassified probably benign
R7135:Ccnk UTSW 12 108186475 missense probably damaging 0.96
R7179:Ccnk UTSW 12 108187258 missense probably damaging 1.00
Posted On2015-04-16