Incidental Mutation 'IGL02341:Megf11'
ID 289090
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Megf11
Ensembl Gene ENSMUSG00000036466
Gene Name multiple EGF-like-domains 11
Synonyms 2410080H04Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.143) question?
Stock # IGL02341
Quality Score
Status
Chromosome 9
Chromosomal Location 64292908-64616487 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 64451902 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Serine at position 109 (G109S)
Ref Sequence ENSEMBL: ENSMUSP00000114035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068967] [ENSMUST00000093829] [ENSMUST00000118485] [ENSMUST00000164113]
AlphaFold Q80T91
Predicted Effect probably damaging
Transcript: ENSMUST00000068967
AA Change: G109S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000065353
Gene: ENSMUSG00000036466
AA Change: G109S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 74 84 N/A INTRINSIC
EGF 101 129 1.85e0 SMART
EGF_Lam 145 184 9.55e-3 SMART
EGF_Lam 188 227 2e-5 SMART
EGF 226 258 5.57e-4 SMART
EGF_Lam 274 313 1.26e-2 SMART
EGF_Lam 317 357 2.52e-2 SMART
EGF_Lam 361 402 4.16e-3 SMART
EGF 401 433 6.21e-2 SMART
EGF 444 476 4.1e-2 SMART
EGF 487 519 7.02e-1 SMART
EGF_Lam 535 574 1.43e-1 SMART
EGF_Lam 578 617 5.04e-2 SMART
EGF 616 650 8.52e0 SMART
EGF 661 693 9.41e-2 SMART
EGF 704 736 8.52e0 SMART
EGF_Lam 752 791 2.99e-4 SMART
EGF 790 822 1.14e0 SMART
transmembrane domain 848 870 N/A INTRINSIC
low complexity region 895 909 N/A INTRINSIC
low complexity region 1022 1037 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000093829
SMART Domains Protein: ENSMUSP00000091349
Gene: ENSMUSG00000036466

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 74 84 N/A INTRINSIC
EGF_Lam 114 153 9.55e-3 SMART
EGF_Lam 157 196 2e-5 SMART
EGF 195 227 5.57e-4 SMART
EGF_Lam 243 282 1.26e-2 SMART
EGF_Lam 286 326 2.52e-2 SMART
EGF_Lam 330 371 4.16e-3 SMART
EGF 370 402 6.21e-2 SMART
EGF 413 445 4.1e-2 SMART
EGF 456 488 7.02e-1 SMART
EGF_Lam 504 543 1.43e-1 SMART
EGF_Lam 547 586 5.04e-2 SMART
EGF 585 619 8.52e0 SMART
EGF 630 662 9.41e-2 SMART
EGF_Lam 678 717 2.99e-4 SMART
EGF 716 748 1.14e0 SMART
transmembrane domain 774 796 N/A INTRINSIC
low complexity region 821 835 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000118485
AA Change: G109S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000114035
Gene: ENSMUSG00000036466
AA Change: G109S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 74 84 N/A INTRINSIC
EGF 101 129 1.85e0 SMART
EGF_Lam 145 184 9.55e-3 SMART
EGF_Lam 188 227 2e-5 SMART
EGF 226 258 5.57e-4 SMART
EGF_Lam 274 313 1.26e-2 SMART
EGF_Lam 317 357 2.52e-2 SMART
EGF_Lam 361 402 4.16e-3 SMART
EGF 401 433 6.21e-2 SMART
EGF 444 476 4.1e-2 SMART
EGF 487 519 7.02e-1 SMART
EGF_Lam 535 574 1.43e-1 SMART
EGF_Lam 578 617 5.04e-2 SMART
EGF 616 650 8.52e0 SMART
EGF 661 693 9.41e-2 SMART
EGF 704 736 8.52e0 SMART
EGF_Lam 752 791 2.99e-4 SMART
EGF 790 822 1.14e0 SMART
transmembrane domain 848 870 N/A INTRINSIC
low complexity region 926 941 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144383
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147388
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148449
Predicted Effect possibly damaging
Transcript: ENSMUST00000164113
AA Change: G109S

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000128672
Gene: ENSMUSG00000036466
AA Change: G109S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 74 84 N/A INTRINSIC
EGF 101 129 1.85e0 SMART
EGF_Lam 145 184 9.55e-3 SMART
EGF_Lam 188 227 2e-5 SMART
EGF 226 258 5.57e-4 SMART
EGF_Lam 274 313 1.26e-2 SMART
EGF_Lam 317 357 2.52e-2 SMART
EGF_Lam 361 402 4.16e-3 SMART
EGF 401 433 6.21e-2 SMART
EGF 444 476 4.1e-2 SMART
EGF 487 519 7.02e-1 SMART
EGF_Lam 535 574 1.43e-1 SMART
EGF_Lam 578 617 5.04e-2 SMART
EGF 616 650 8.52e0 SMART
EGF 661 693 9.41e-2 SMART
EGF_Lam 709 748 2.99e-4 SMART
EGF 747 779 1.14e0 SMART
transmembrane domain 805 827 N/A INTRINSIC
low complexity region 852 866 N/A INTRINSIC
low complexity region 979 994 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted allele exhibit abnormal spacing of horizontal cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arid2 C T 15: 96,270,066 (GRCm39) S1393L probably benign Het
Bahcc1 T A 11: 120,163,346 (GRCm39) I548N probably damaging Het
Baiap3 A T 17: 25,467,290 (GRCm39) L405Q possibly damaging Het
Cacna1g T G 11: 94,352,978 (GRCm39) Q349P probably damaging Het
Ccdc30 T C 4: 119,213,978 (GRCm39) T184A possibly damaging Het
Ccdc63 A G 5: 122,251,261 (GRCm39) I383T probably benign Het
Ccnk A G 12: 108,161,989 (GRCm39) E298G unknown Het
Ccnt1 T C 15: 98,444,664 (GRCm39) E223G possibly damaging Het
Clcc1 T A 3: 108,580,699 (GRCm39) L333I possibly damaging Het
Cyp2b10 G A 7: 25,610,667 (GRCm39) R59Q probably benign Het
Cyp3a41b T A 5: 145,510,461 (GRCm39) T138S probably benign Het
Dennd4a C T 9: 64,749,843 (GRCm39) R145* probably null Het
Dnah8 A T 17: 30,966,231 (GRCm39) I2474F probably damaging Het
Dok1 T C 6: 83,010,035 (GRCm39) T25A probably damaging Het
Ears2 G A 7: 121,638,987 (GRCm39) A479V probably benign Het
Erc1 T A 6: 119,571,934 (GRCm39) I981F possibly damaging Het
Gm8730 A G 8: 103,591,775 (GRCm39) noncoding transcript Het
Gm9962 C T 7: 57,037,042 (GRCm39) probably benign Het
Has3 A T 8: 107,600,637 (GRCm39) Y33F probably damaging Het
Hk1 A G 10: 62,120,159 (GRCm39) S607P possibly damaging Het
Hlcs T A 16: 94,031,969 (GRCm39) I612F probably damaging Het
Llgl2 T A 11: 115,741,946 (GRCm39) S663T possibly damaging Het
Lrriq1 T C 10: 103,060,802 (GRCm39) H100R probably benign Het
Lypd8l T C 11: 58,503,656 (GRCm39) S17G possibly damaging Het
Magi2 T A 5: 20,671,201 (GRCm39) I678N probably damaging Het
Morc2b A T 17: 33,356,281 (GRCm39) I497K probably damaging Het
Mybpc2 A C 7: 44,164,354 (GRCm39) S404A probably benign Het
Mylip A G 13: 45,544,752 (GRCm39) R59G probably damaging Het
Mylk3 A T 8: 86,078,601 (GRCm39) I501N probably damaging Het
Myo19 A G 11: 84,778,871 (GRCm39) probably benign Het
Nat2 A G 8: 67,954,370 (GRCm39) Y160C possibly damaging Het
Nf1 C T 11: 79,455,752 (GRCm39) A2554V probably benign Het
Niban3 A T 8: 72,056,443 (GRCm39) N381I possibly damaging Het
Ninl A T 2: 150,786,525 (GRCm39) C153* probably null Het
Nlrp5 C T 7: 23,103,577 (GRCm39) R15C probably benign Het
Nphp4 A T 4: 152,639,926 (GRCm39) probably benign Het
Obscn C A 11: 59,026,651 (GRCm39) R184L probably benign Het
Or6c202 T A 10: 128,996,302 (GRCm39) I184F probably benign Het
Or6c6c A T 10: 129,541,358 (GRCm39) T204S probably damaging Het
Or6c8 A T 10: 128,915,330 (GRCm39) C167* probably null Het
Phip A T 9: 82,814,936 (GRCm39) V262D probably damaging Het
Ptprg T A 14: 12,154,360 (GRCm38) S694T probably benign Het
Reck T A 4: 43,925,160 (GRCm39) D466E probably damaging Het
Rimbp2 G T 5: 128,878,025 (GRCm39) Y213* probably null Het
Scn2a C T 2: 65,518,721 (GRCm39) T365M probably damaging Het
Scpep1 T A 11: 88,835,314 (GRCm39) T120S probably benign Het
Sp7 T A 15: 102,267,657 (GRCm39) T50S possibly damaging Het
Tbc1d1 A G 5: 64,432,750 (GRCm39) R304G probably damaging Het
Tiam1 A G 16: 89,695,257 (GRCm39) S67P probably damaging Het
Tjp1 G A 7: 64,962,382 (GRCm39) T1185I probably damaging Het
Tspan2 T A 3: 102,672,529 (GRCm39) I178N probably damaging Het
Tusc2 T A 9: 107,442,109 (GRCm39) *103R probably null Het
Uggt1 A T 1: 36,203,600 (GRCm39) *47R probably null Het
Unc13c T A 9: 73,840,492 (GRCm39) I120F possibly damaging Het
Vcpip1 T A 1: 9,795,175 (GRCm39) K1065N possibly damaging Het
Zfp532 C A 18: 65,757,849 (GRCm39) P594Q probably damaging Het
Other mutations in Megf11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00979:Megf11 APN 9 64,416,009 (GRCm39) missense probably damaging 1.00
IGL01285:Megf11 APN 9 64,567,728 (GRCm39) missense probably damaging 1.00
IGL01309:Megf11 APN 9 64,588,698 (GRCm39) missense probably benign 0.01
IGL01953:Megf11 APN 9 64,597,370 (GRCm39) missense probably damaging 1.00
IGL02407:Megf11 APN 9 64,587,531 (GRCm39) missense probably damaging 1.00
IGL02621:Megf11 APN 9 64,601,214 (GRCm39) missense probably benign 0.07
R0277:Megf11 UTSW 9 64,598,632 (GRCm39) critical splice donor site probably null
R0386:Megf11 UTSW 9 64,547,360 (GRCm39) missense probably damaging 1.00
R1354:Megf11 UTSW 9 64,560,459 (GRCm39) missense probably benign 0.00
R1709:Megf11 UTSW 9 64,602,694 (GRCm39) missense probably damaging 1.00
R1865:Megf11 UTSW 9 64,587,581 (GRCm39) missense probably benign 0.39
R1895:Megf11 UTSW 9 64,586,558 (GRCm39) missense probably damaging 1.00
R1946:Megf11 UTSW 9 64,586,558 (GRCm39) missense probably damaging 1.00
R2221:Megf11 UTSW 9 64,567,713 (GRCm39) missense possibly damaging 0.63
R2223:Megf11 UTSW 9 64,567,713 (GRCm39) missense possibly damaging 0.63
R3552:Megf11 UTSW 9 64,602,745 (GRCm39) missense possibly damaging 0.75
R4641:Megf11 UTSW 9 64,597,407 (GRCm39) missense possibly damaging 0.93
R4746:Megf11 UTSW 9 64,416,027 (GRCm39) missense probably damaging 1.00
R5594:Megf11 UTSW 9 64,593,755 (GRCm39) missense probably damaging 1.00
R5716:Megf11 UTSW 9 64,413,392 (GRCm39) missense possibly damaging 0.72
R5898:Megf11 UTSW 9 64,593,246 (GRCm39) missense probably damaging 1.00
R5960:Megf11 UTSW 9 64,567,731 (GRCm39) missense probably benign 0.00
R6372:Megf11 UTSW 9 64,613,907 (GRCm39) missense probably damaging 1.00
R6811:Megf11 UTSW 9 64,451,923 (GRCm39) missense probably damaging 0.99
R6868:Megf11 UTSW 9 64,587,591 (GRCm39) missense probably damaging 1.00
R6980:Megf11 UTSW 9 64,613,132 (GRCm39) missense probably damaging 1.00
R6984:Megf11 UTSW 9 64,593,734 (GRCm39) missense probably benign
R7155:Megf11 UTSW 9 64,555,233 (GRCm39) missense probably null 1.00
R7638:Megf11 UTSW 9 64,586,535 (GRCm39) missense probably damaging 0.96
R7643:Megf11 UTSW 9 64,613,914 (GRCm39) missense probably damaging 1.00
R7688:Megf11 UTSW 9 64,599,146 (GRCm39) missense possibly damaging 0.92
R7840:Megf11 UTSW 9 64,602,709 (GRCm39) missense possibly damaging 0.94
R8744:Megf11 UTSW 9 64,451,970 (GRCm39) critical splice donor site probably null
R8799:Megf11 UTSW 9 64,588,673 (GRCm39) missense probably benign 0.05
R9383:Megf11 UTSW 9 64,545,732 (GRCm39) missense probably damaging 1.00
R9493:Megf11 UTSW 9 64,547,376 (GRCm39) missense probably damaging 1.00
R9797:Megf11 UTSW 9 64,545,591 (GRCm39) missense possibly damaging 0.83
V5088:Megf11 UTSW 9 64,597,351 (GRCm39) nonsense probably null
V5622:Megf11 UTSW 9 64,597,351 (GRCm39) nonsense probably null
V5622:Megf11 UTSW 9 64,597,351 (GRCm39) nonsense probably null
Z1088:Megf11 UTSW 9 64,567,758 (GRCm39) missense probably damaging 1.00
Z1177:Megf11 UTSW 9 64,587,608 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16