Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02342:Or2ag1'

289127

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2ag1

Ensembl Gene

ENSMUSG00000109058

Gene Name

olfactory receptor family 2 subfamily AG member 1

Synonyms

Olfr705, MOR283-2, GA_x6K02T2PBJ9-9256348-9255398

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

IGL02342

Quality Score

Status

Chromosome

Chromosomal Location

106472500-106473450 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 106313232 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 219 (S219P)

Ref Sequence

ENSEMBL: ENSMUSP00000149773 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080925] [ENSMUST00000216868]

AlphaFold

Q9EPF7

Predicted Effect

probably benign
Transcript: ENSMUST00000080925
AA Change: S219P

PolyPhen 2 Score 0.129 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000079726
Gene: ENSMUSG00000073900
AA Change: S219P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2.1e-48	PFAM
Pfam:7TM_GPCR_Srsx	35	305	1.5e-7	PFAM
Pfam:7tm_1	41	290	1.5e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000216868
AA Change: S219P

PolyPhen 2 Score 0.129 (Sensitivity: 0.93; Specificity: 0.86)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9030612E09Rik	C	A	10: 43,050,997 (GRCm39)	P97Q	probably damaging	Het
Abcb10	A	T	8: 124,688,773 (GRCm39)	V501E	probably damaging	Het
Acsf3	T	C	8: 123,544,237 (GRCm39)	Y572H	probably benign	Het
Adamts3	A	T	5: 89,839,332 (GRCm39)		probably null	Het
Alox8	A	G	11: 69,077,053 (GRCm39)	L480P	probably damaging	Het
Arhgap35	G	A	7: 16,296,305 (GRCm39)	T920I	probably benign	Het
Brca2	C	A	5: 150,466,289 (GRCm39)	L2018M	possibly damaging	Het
Brdt	C	A	5: 107,490,069 (GRCm39)	H45N	probably damaging	Het
C1s2	A	G	6: 124,609,075 (GRCm39)	F155L	probably damaging	Het
Ccser2	A	G	14: 36,640,562 (GRCm39)		probably benign	Het
Cd8a	T	A	6: 71,350,723 (GRCm39)	C63S	probably damaging	Het
Clk2	A	T	3: 89,082,998 (GRCm39)	T424S	probably benign	Het
Cntn1	A	G	15: 92,143,898 (GRCm39)	E287G	probably benign	Het
Cobl	A	C	11: 12,203,672 (GRCm39)	V928G	possibly damaging	Het
Col12a1	A	G	9: 79,557,178 (GRCm39)		probably null	Het
Crnkl1	A	T	2: 145,766,633 (GRCm39)		probably null	Het
Defb26	T	C	2: 152,350,121 (GRCm39)	N53S	possibly damaging	Het
Duox1	A	T	2: 122,177,793 (GRCm39)	T1526S	probably damaging	Het
Dync2h1	A	G	9: 7,142,246 (GRCm39)	L1233P	probably damaging	Het
Eif5a2	A	G	3: 28,847,910 (GRCm39)	E116G	possibly damaging	Het
Garin1b	A	G	6: 29,323,829 (GRCm39)	T185A	possibly damaging	Het
Gdap2	G	A	3: 100,085,632 (GRCm39)	A185T	probably damaging	Het
Grm8	T	C	6: 27,363,803 (GRCm39)	R571G	probably benign	Het
Hjv	G	A	3: 96,435,488 (GRCm39)	D249N	possibly damaging	Het
Hsp90b1	T	C	10: 86,531,603 (GRCm39)		probably null	Het
Ift70a1	G	T	2: 75,810,976 (GRCm39)	T369K	probably benign	Het
Ighv1-75	T	G	12: 115,797,878 (GRCm39)		probably benign	Het
Ikzf1	A	G	11: 11,650,216 (GRCm39)		probably benign	Het
Itprid2	A	G	2: 79,490,629 (GRCm39)	N943S	probably benign	Het
Kdm4d	A	G	9: 14,374,860 (GRCm39)	W333R	probably damaging	Het
Lama3	A	T	18: 12,624,533 (GRCm39)	N1426I	probably damaging	Het
Lmbrd1	A	G	1: 24,743,959 (GRCm39)	Y119C	probably damaging	Het
Mctp1	A	G	13: 77,172,976 (GRCm39)	Y884C	probably damaging	Het
Naip6	G	T	13: 100,439,748 (GRCm39)	P340T	possibly damaging	Het
Nfkbib	G	T	7: 28,461,528 (GRCm39)	H70N	probably damaging	Het
Nol4	A	T	18: 22,903,926 (GRCm39)		probably benign	Het
Obscn	C	T	11: 58,891,914 (GRCm39)	A6873T	probably benign	Het
Or51b4	T	A	7: 103,530,587 (GRCm39)	I288F	probably benign	Het
Or6x1	T	A	9: 40,098,823 (GRCm39)	N137K	probably benign	Het
Paqr6	A	G	3: 88,273,491 (GRCm39)	Y136C	probably damaging	Het
Pcdh18	T	A	3: 49,710,493 (GRCm39)	D274V	probably damaging	Het
Phip	A	G	9: 82,768,745 (GRCm39)	Y1196H	probably damaging	Het
Prc1	T	C	7: 79,959,190 (GRCm39)	L345S	probably damaging	Het
Smpdl3a	A	G	10: 57,685,276 (GRCm39)		probably benign	Het
Tac1	G	T	6: 7,559,119 (GRCm39)		probably null	Het
Tasor	T	A	14: 27,198,624 (GRCm39)	S1319T	possibly damaging	Het
Tg	A	G	15: 66,636,140 (GRCm39)	T576A	probably benign	Het
Thbs2	A	T	17: 14,896,578 (GRCm39)	D770E	probably damaging	Het
Tmem117	T	C	15: 94,909,331 (GRCm39)	V248A	possibly damaging	Het
Trpm8	T	C	1: 88,255,972 (GRCm39)	I209T	possibly damaging	Het
Wrap53	A	G	11: 69,454,417 (GRCm39)	F244L	probably damaging	Het
Wrap73	A	T	4: 154,233,237 (GRCm39)	Q137L	probably benign	Het
Zfhx4	A	T	3: 5,467,434 (GRCm39)	T2531S	probably benign	Het

Other mutations in Or2ag1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01743:Or2ag1	APN	7	106,313,541 (GRCm39)	missense	possibly damaging	0.48
IGL02203:Or2ag1	APN	7	106,313,837 (GRCm39)	missense	probably benign	0.02
IGL02544:Or2ag1	APN	7	106,313,742 (GRCm39)	missense	probably benign	0.39
IGL02569:Or2ag1	APN	7	106,313,793 (GRCm39)	missense	probably benign	0.00
PIT4651001:Or2ag1	UTSW	7	106,472,730 (GRCm39)	missense	probably damaging	1.00
R0501:Or2ag1	UTSW	7	106,313,810 (GRCm39)	missense	probably benign	0.01
R0504:Or2ag1	UTSW	7	106,313,908 (GRCm39)	splice site	probably benign
R0536:Or2ag1	UTSW	7	106,313,528 (GRCm39)	missense	probably damaging	1.00
R0633:Or2ag1	UTSW	7	106,313,184 (GRCm39)	missense	probably benign	0.03
R0686:Or2ag1	UTSW	7	106,313,585 (GRCm39)	missense	probably damaging	0.98
R1225:Or2ag1	UTSW	7	106,313,731 (GRCm39)	missense	probably benign	0.22
R1725:Or2ag1	UTSW	7	106,313,265 (GRCm39)	missense	probably benign
R1864:Or2ag1	UTSW	7	106,313,030 (GRCm39)	missense	possibly damaging	0.87
R2065:Or2ag1	UTSW	7	106,313,373 (GRCm39)	missense	probably benign	0.12
R2068:Or2ag1	UTSW	7	106,313,373 (GRCm39)	missense	probably benign	0.12
R2081:Or2ag1	UTSW	7	106,313,405 (GRCm39)	missense	probably benign
R4135:Or2ag1	UTSW	7	106,313,210 (GRCm39)	missense	probably damaging	1.00
R5649:Or2ag1	UTSW	7	106,313,373 (GRCm39)	missense	possibly damaging	0.89
R5858:Or2ag1	UTSW	7	106,472,975 (GRCm39)	missense	probably benign	0.01
R6083:Or2ag1	UTSW	7	106,472,789 (GRCm39)	missense	probably damaging	0.98
R7144:Or2ag1	UTSW	7	106,473,075 (GRCm39)	missense	probably damaging	1.00
R7214:Or2ag1	UTSW	7	106,473,474 (GRCm39)	start gained	probably benign
R7366:Or2ag1	UTSW	7	106,472,603 (GRCm39)	missense	probably damaging	1.00
R7445:Or2ag1	UTSW	7	106,472,549 (GRCm39)	missense	possibly damaging	0.55
R8171:Or2ag1	UTSW	7	106,313,826 (GRCm39)	missense
R8171:Or2ag1	UTSW	7	106,313,825 (GRCm39)	missense	probably benign
R8986:Or2ag1	UTSW	7	106,473,050 (GRCm39)	missense	probably benign	0.00
R9285:Or2ag1	UTSW	7	106,472,715 (GRCm39)	missense	probably benign	0.11

Posted On

2015-04-16