Incidental Mutation 'IGL02343:Cry2'
ID 289171
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cry2
Ensembl Gene ENSMUSG00000068742
Gene Name cryptochrome circadian regulator 2
Synonyms D130054K12Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.540) question?
Stock # IGL02343
Quality Score
Status
Chromosome 2
Chromosomal Location 92233991-92264388 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 92257266 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 101 (V101E)
Ref Sequence ENSEMBL: ENSMUSP00000106909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090559] [ENSMUST00000111278]
AlphaFold Q9R194
Predicted Effect possibly damaging
Transcript: ENSMUST00000090559
AA Change: V101E

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000088047
Gene: ENSMUSG00000068742
AA Change: V101E

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
Pfam:DNA_photolyase 23 187 2.4e-50 PFAM
Pfam:FAD_binding_7 231 504 4.4e-89 PFAM
low complexity region 562 573 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000111278
AA Change: V101E

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000106909
Gene: ENSMUSG00000068742
AA Change: V101E

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
Pfam:DNA_photolyase 23 189 3.6e-50 PFAM
Pfam:FAD_binding_7 230 506 1.4e-105 PFAM
low complexity region 562 573 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125488
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126002
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144842
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. [provided by RefSeq, Feb 2014]
PHENOTYPE: Homozygotes for targeted null mutations exhibit a one-hour longer circadian period under constant darkness, and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd5 T A 2: 22,977,507 (GRCm39) N168K possibly damaging Het
Aig1 T C 10: 13,744,418 (GRCm39) M29V probably damaging Het
Albfm1 C A 5: 90,727,473 (GRCm39) H364N probably damaging Het
Apba2 A G 7: 64,344,894 (GRCm39) E28G probably damaging Het
Bglap3 T C 3: 88,276,423 (GRCm39) N45S possibly damaging Het
Cables2 A G 2: 179,902,072 (GRCm39) probably null Het
Cd109 A G 9: 78,596,237 (GRCm39) probably benign Het
Cdk1 T C 10: 69,176,331 (GRCm39) N259D probably benign Het
Ces1h A G 8: 94,078,654 (GRCm39) *563R probably null Het
Cfap46 C T 7: 139,262,425 (GRCm39) A115T probably damaging Het
Cyp4a31 A G 4: 115,421,026 (GRCm39) Y38C probably damaging Het
Dip2a T C 10: 76,155,312 (GRCm39) Y130C probably benign Het
Eps8l1 A G 7: 4,475,123 (GRCm39) T366A probably benign Het
Esr2 C T 12: 76,192,119 (GRCm39) R303H probably benign Het
Fbxo41 T G 6: 85,455,153 (GRCm39) L617F possibly damaging Het
Fbxw15 A T 9: 109,381,723 (GRCm39) probably benign Het
Lrriq1 T A 10: 103,070,024 (GRCm39) probably benign Het
Me1 A T 9: 86,536,694 (GRCm39) probably null Het
Moxd1 G A 10: 24,155,762 (GRCm39) V289I probably damaging Het
Muc19 T G 15: 91,778,428 (GRCm39) noncoding transcript Het
Myo15b A G 11: 115,764,226 (GRCm39) probably benign Het
Nav1 A T 1: 135,382,490 (GRCm39) L1264* probably null Het
Nhlrc4 T C 17: 26,162,335 (GRCm39) *137W probably null Het
Nrxn3 A G 12: 88,762,123 (GRCm39) T57A probably damaging Het
Or10g3 T A 14: 52,609,934 (GRCm39) D192V probably damaging Het
Orc2 A T 1: 58,508,825 (GRCm39) probably null Het
Rpap2 G A 5: 107,766,047 (GRCm39) probably null Het
S100a9 T C 3: 90,602,531 (GRCm39) H21R probably damaging Het
Spz1 T A 13: 92,712,054 (GRCm39) M141L probably benign Het
Stk40 A G 4: 126,030,695 (GRCm39) Y305C probably damaging Het
Stra6l A G 4: 45,869,588 (GRCm39) Q218R probably damaging Het
T C A 17: 8,658,732 (GRCm39) probably benign Het
Tep1 T C 14: 51,066,704 (GRCm39) D2298G probably damaging Het
Trim40 A T 17: 37,200,030 (GRCm39) L16Q probably benign Het
Tubb4a T C 17: 57,388,538 (GRCm39) I163V probably benign Het
Vwc2 T A 11: 11,066,532 (GRCm39) C207S probably damaging Het
Zfp407 A G 18: 84,227,849 (GRCm39) I1920T possibly damaging Het
Zfp429 T C 13: 67,538,844 (GRCm39) E200G probably damaging Het
Zfp451 C T 1: 33,815,574 (GRCm39) C792Y probably damaging Het
Other mutations in Cry2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01995:Cry2 APN 2 92,254,977 (GRCm39) missense probably benign 0.15
IGL02167:Cry2 APN 2 92,264,166 (GRCm39) missense possibly damaging 0.93
IGL02183:Cry2 APN 2 92,243,384 (GRCm39) missense probably damaging 0.99
IGL02432:Cry2 APN 2 92,244,012 (GRCm39) missense probably damaging 0.99
IGL02725:Cry2 APN 2 92,243,605 (GRCm39) splice site probably benign
IGL02932:Cry2 APN 2 92,243,462 (GRCm39) nonsense probably null
IGL03122:Cry2 APN 2 92,243,640 (GRCm39) missense probably damaging 1.00
IGL03366:Cry2 APN 2 92,244,060 (GRCm39) missense probably damaging 1.00
R0679:Cry2 UTSW 2 92,244,060 (GRCm39) missense probably damaging 1.00
R1325:Cry2 UTSW 2 92,244,115 (GRCm39) missense probably damaging 1.00
R1862:Cry2 UTSW 2 92,254,911 (GRCm39) missense probably damaging 1.00
R1891:Cry2 UTSW 2 92,243,985 (GRCm39) missense possibly damaging 0.93
R2189:Cry2 UTSW 2 92,242,037 (GRCm39) missense possibly damaging 0.84
R4032:Cry2 UTSW 2 92,244,172 (GRCm39) missense probably benign 0.00
R4689:Cry2 UTSW 2 92,254,899 (GRCm39) missense probably benign 0.38
R5130:Cry2 UTSW 2 92,254,944 (GRCm39) missense probably benign 0.28
R5145:Cry2 UTSW 2 92,243,405 (GRCm39) missense probably benign
R5970:Cry2 UTSW 2 92,243,312 (GRCm39) missense probably benign 0.08
R6179:Cry2 UTSW 2 92,244,187 (GRCm39) missense probably damaging 0.98
R7102:Cry2 UTSW 2 92,243,438 (GRCm39) missense probably damaging 0.99
R7158:Cry2 UTSW 2 92,244,060 (GRCm39) missense probably damaging 1.00
R7213:Cry2 UTSW 2 92,244,004 (GRCm39) missense probably benign 0.00
R7257:Cry2 UTSW 2 92,243,326 (GRCm39) missense possibly damaging 0.67
R7378:Cry2 UTSW 2 92,244,009 (GRCm39) missense probably damaging 1.00
R7427:Cry2 UTSW 2 92,243,392 (GRCm39) missense possibly damaging 0.74
R7428:Cry2 UTSW 2 92,243,392 (GRCm39) missense possibly damaging 0.74
R7440:Cry2 UTSW 2 92,243,983 (GRCm39) missense probably damaging 1.00
R7531:Cry2 UTSW 2 92,243,350 (GRCm39) missense probably damaging 0.98
R8234:Cry2 UTSW 2 92,242,974 (GRCm39) missense probably benign
R8350:Cry2 UTSW 2 92,244,286 (GRCm39) missense probably benign 0.00
R8450:Cry2 UTSW 2 92,244,286 (GRCm39) missense probably benign 0.00
R8496:Cry2 UTSW 2 92,257,284 (GRCm39) missense probably damaging 1.00
R9172:Cry2 UTSW 2 92,243,993 (GRCm39) missense probably damaging 1.00
R9283:Cry2 UTSW 2 92,244,249 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16