Incidental Mutation 'IGL02343:Or10g3'
ID 289186
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10g3
Ensembl Gene ENSMUSG00000094140
Gene Name olfactory receptor family 10 subfamily G member 3
Synonyms GA_x6K02T2RJGY-622120-623061, MOR223-5, Olfr1512
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # IGL02343
Quality Score
Status
Chromosome 14
Chromosomal Location 52609567-52610508 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 52609934 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 192 (D192V)
Ref Sequence ENSEMBL: ENSMUSP00000149717 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071221] [ENSMUST00000214980]
AlphaFold Q8VF72
Predicted Effect probably damaging
Transcript: ENSMUST00000071221
AA Change: D192V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071208
Gene: ENSMUSG00000094140
AA Change: D192V

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.1e-48 PFAM
Pfam:7tm_1 41 290 2.9e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192537
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200261
Predicted Effect probably damaging
Transcript: ENSMUST00000214980
AA Change: D192V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd5 T A 2: 22,977,507 (GRCm39) N168K possibly damaging Het
Aig1 T C 10: 13,744,418 (GRCm39) M29V probably damaging Het
Albfm1 C A 5: 90,727,473 (GRCm39) H364N probably damaging Het
Apba2 A G 7: 64,344,894 (GRCm39) E28G probably damaging Het
Bglap3 T C 3: 88,276,423 (GRCm39) N45S possibly damaging Het
Cables2 A G 2: 179,902,072 (GRCm39) probably null Het
Cd109 A G 9: 78,596,237 (GRCm39) probably benign Het
Cdk1 T C 10: 69,176,331 (GRCm39) N259D probably benign Het
Ces1h A G 8: 94,078,654 (GRCm39) *563R probably null Het
Cfap46 C T 7: 139,262,425 (GRCm39) A115T probably damaging Het
Cry2 A T 2: 92,257,266 (GRCm39) V101E possibly damaging Het
Cyp4a31 A G 4: 115,421,026 (GRCm39) Y38C probably damaging Het
Dip2a T C 10: 76,155,312 (GRCm39) Y130C probably benign Het
Eps8l1 A G 7: 4,475,123 (GRCm39) T366A probably benign Het
Esr2 C T 12: 76,192,119 (GRCm39) R303H probably benign Het
Fbxo41 T G 6: 85,455,153 (GRCm39) L617F possibly damaging Het
Fbxw15 A T 9: 109,381,723 (GRCm39) probably benign Het
Lrriq1 T A 10: 103,070,024 (GRCm39) probably benign Het
Me1 A T 9: 86,536,694 (GRCm39) probably null Het
Moxd1 G A 10: 24,155,762 (GRCm39) V289I probably damaging Het
Muc19 T G 15: 91,778,428 (GRCm39) noncoding transcript Het
Myo15b A G 11: 115,764,226 (GRCm39) probably benign Het
Nav1 A T 1: 135,382,490 (GRCm39) L1264* probably null Het
Nhlrc4 T C 17: 26,162,335 (GRCm39) *137W probably null Het
Nrxn3 A G 12: 88,762,123 (GRCm39) T57A probably damaging Het
Orc2 A T 1: 58,508,825 (GRCm39) probably null Het
Rpap2 G A 5: 107,766,047 (GRCm39) probably null Het
S100a9 T C 3: 90,602,531 (GRCm39) H21R probably damaging Het
Spz1 T A 13: 92,712,054 (GRCm39) M141L probably benign Het
Stk40 A G 4: 126,030,695 (GRCm39) Y305C probably damaging Het
Stra6l A G 4: 45,869,588 (GRCm39) Q218R probably damaging Het
T C A 17: 8,658,732 (GRCm39) probably benign Het
Tep1 T C 14: 51,066,704 (GRCm39) D2298G probably damaging Het
Trim40 A T 17: 37,200,030 (GRCm39) L16Q probably benign Het
Tubb4a T C 17: 57,388,538 (GRCm39) I163V probably benign Het
Vwc2 T A 11: 11,066,532 (GRCm39) C207S probably damaging Het
Zfp407 A G 18: 84,227,849 (GRCm39) I1920T possibly damaging Het
Zfp429 T C 13: 67,538,844 (GRCm39) E200G probably damaging Het
Zfp451 C T 1: 33,815,574 (GRCm39) C792Y probably damaging Het
Other mutations in Or10g3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01328:Or10g3 APN 14 52,609,967 (GRCm39) missense probably damaging 1.00
IGL01375:Or10g3 APN 14 52,609,865 (GRCm39) missense probably damaging 0.99
R1443:Or10g3 UTSW 14 52,610,408 (GRCm39) missense probably damaging 1.00
R1902:Or10g3 UTSW 14 52,610,174 (GRCm39) missense possibly damaging 0.81
R1903:Or10g3 UTSW 14 52,610,174 (GRCm39) missense possibly damaging 0.81
R3115:Or10g3 UTSW 14 52,610,397 (GRCm39) missense probably damaging 1.00
R4752:Or10g3 UTSW 14 52,609,764 (GRCm39) missense probably damaging 1.00
R5345:Or10g3 UTSW 14 52,609,725 (GRCm39) nonsense probably null
R5689:Or10g3 UTSW 14 52,610,214 (GRCm39) missense possibly damaging 0.83
R6185:Or10g3 UTSW 14 52,610,019 (GRCm39) missense possibly damaging 0.91
R6287:Or10g3 UTSW 14 52,609,748 (GRCm39) missense probably damaging 1.00
R6757:Or10g3 UTSW 14 52,610,172 (GRCm39) missense probably damaging 1.00
R8751:Or10g3 UTSW 14 52,610,420 (GRCm39) missense probably benign 0.03
R8855:Or10g3 UTSW 14 52,610,196 (GRCm39) missense probably damaging 1.00
R8866:Or10g3 UTSW 14 52,610,196 (GRCm39) missense probably damaging 1.00
R9038:Or10g3 UTSW 14 52,609,716 (GRCm39) missense probably damaging 0.99
R9450:Or10g3 UTSW 14 52,610,110 (GRCm39) nonsense probably null
Posted On 2015-04-16