Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02351:Zfp418'

289504

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp418

Ensembl Gene

ENSMUSG00000034538

Gene Name

zinc finger protein 418

Synonyms

A230102I05Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL02351

Quality Score

Status

Chromosome

Chromosomal Location

7174352-7186559 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 7177690 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000057159 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051435]

AlphaFold

Q8BFS8

Predicted Effect

probably benign
Transcript: ENSMUST00000051435

SMART Domains

Protein: ENSMUSP00000057159
Gene: ENSMUSG00000034538

Domain	Start	End	E-Value	Type
KRAB	25	78	2.58e-17	SMART
low complexity region	196	211	N/A	INTRINSIC
ZnF_C2H2	256	278	6.32e-3	SMART
ZnF_C2H2	284	306	2.57e-3	SMART
ZnF_C2H2	312	334	1.56e-2	SMART
ZnF_C2H2	340	362	1.36e-2	SMART
ZnF_C2H2	368	390	1.82e-3	SMART
ZnF_C2H2	396	418	1.04e-3	SMART
ZnF_C2H2	424	446	2.75e-3	SMART
ZnF_C2H2	452	474	4.47e-3	SMART
ZnF_C2H2	480	502	1.58e-3	SMART
ZnF_C2H2	508	530	8.6e-5	SMART
ZnF_C2H2	536	558	7.78e-3	SMART
ZnF_C2H2	564	586	1.5e-4	SMART
ZnF_C2H2	592	614	4.54e-4	SMART
ZnF_C2H2	620	642	5.59e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209387

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi3bp	A	G	16: 56,474,418 (GRCm39)	T448A	possibly damaging	Het
Adamtsl1	T	A	4: 86,075,110 (GRCm39)		probably null	Het
Adgra3	A	G	5: 50,215,900 (GRCm39)	V73A	probably benign	Het
Aggf1	T	C	13: 95,489,358 (GRCm39)		probably benign	Het
Aktip	C	T	8: 91,853,520 (GRCm39)	V96I	possibly damaging	Het
Atm	A	G	9: 53,433,476 (GRCm39)	I258T	probably benign	Het
Baz1b	C	T	5: 135,273,160 (GRCm39)	T1428I	probably damaging	Het
C3ar1	A	T	6: 122,826,934 (GRCm39)	Y428N	probably damaging	Het
Cadps	A	G	14: 12,597,380 (GRCm38)	S437P	probably damaging	Het
Car4	C	T	11: 84,856,593 (GRCm39)	P294S	probably damaging	Het
Cenpq	A	G	17: 41,235,223 (GRCm39)	L213P	probably damaging	Het
Cept1	A	G	3: 106,446,504 (GRCm39)		probably null	Het
Cln6	A	G	9: 62,754,407 (GRCm39)	I150V	probably benign	Het
Cyb5r3	T	C	15: 83,045,136 (GRCm39)	T94A	probably benign	Het
Cyp2c67	A	G	19: 39,605,861 (GRCm39)	M345T	probably damaging	Het
Dapk2	T	A	9: 66,153,805 (GRCm39)	I187N	probably damaging	Het
Dkk2	A	G	3: 131,883,673 (GRCm39)	D191G	probably benign	Het
Dnah8	T	A	17: 30,986,785 (GRCm39)	F3145I	probably damaging	Het
Dock1	A	C	7: 134,710,548 (GRCm39)	D1190A	possibly damaging	Het
Ehhadh	T	A	16: 21,581,620 (GRCm39)	L457F	probably damaging	Het
Ercc6l2	T	C	13: 64,001,497 (GRCm39)	L552P	probably damaging	Het
Ghrhr	T	G	6: 55,361,138 (GRCm39)	I284S	probably damaging	Het
Gm10288	A	T	3: 146,544,954 (GRCm39)		noncoding transcript	Het
Gp6	T	G	7: 4,397,507 (GRCm39)	I19L	probably benign	Het
Gria4	G	A	9: 4,456,206 (GRCm39)	S698L	possibly damaging	Het
Ifng	A	T	10: 118,278,410 (GRCm39)	I53F	possibly damaging	Het
Kazn	A	C	4: 141,874,327 (GRCm39)		probably null	Het
Khk	A	T	5: 31,085,848 (GRCm39)	I136F	probably damaging	Het
Lnx1	T	A	5: 74,788,027 (GRCm39)	N98Y	probably damaging	Het
Lsp1	T	C	7: 142,042,679 (GRCm39)		probably null	Het
Lta4h	A	T	10: 93,314,329 (GRCm39)	N467I	probably benign	Het
Mcmbp	C	A	7: 128,311,505 (GRCm39)		probably null	Het
Me2	A	T	18: 73,931,038 (GRCm39)	I85K	probably benign	Het
Muc4	C	T	16: 32,569,804 (GRCm39)	T288I	possibly damaging	Het
Nadsyn1	A	T	7: 143,353,649 (GRCm39)	Y525N	probably damaging	Het
Nt5e	G	A	9: 88,209,946 (GRCm39)	V70M	probably damaging	Het
Or52e4	G	A	7: 104,706,182 (GRCm39)	G243D	probably damaging	Het
Or8b36	A	T	9: 37,937,332 (GRCm39)	I77L	possibly damaging	Het
Or9k7	T	G	10: 130,046,603 (GRCm39)	Y132S	probably damaging	Het
Pkd1l3	A	G	8: 110,373,129 (GRCm39)		probably benign	Het
Ppm1d	A	T	11: 85,236,541 (GRCm39)	E440V	probably damaging	Het
Pramel32	A	T	4: 88,546,127 (GRCm39)	I405N	probably damaging	Het
Ripor2	A	T	13: 24,915,572 (GRCm39)	E1047D	probably damaging	Het
Rwdd2b	G	A	16: 87,234,336 (GRCm39)	A18V	probably benign	Het
Serpina5	G	T	12: 104,068,384 (GRCm39)	K148N	probably damaging	Het
Setx	A	G	2: 29,036,976 (GRCm39)	K1154E	probably benign	Het
Skap1	T	A	11: 96,599,382 (GRCm39)		probably null	Het
Spcs2	T	C	7: 99,498,241 (GRCm39)	K81R	probably damaging	Het
Stt3b	T	A	9: 115,079,975 (GRCm39)	M646L	possibly damaging	Het
Suco	T	C	1: 161,646,195 (GRCm39)	T1169A	probably benign	Het
Susd1	A	T	4: 59,427,985 (GRCm39)	Y66*	probably null	Het
Trim34a	T	A	7: 103,910,441 (GRCm39)	C414*	probably null	Het
Trim58	G	A	11: 58,542,176 (GRCm39)	G379S	probably damaging	Het
Vmn2r50	T	A	7: 9,787,002 (GRCm39)	Q35L	probably benign	Het
Zfp57	G	A	17: 37,320,919 (GRCm39)	V258I	probably benign	Het
Zng1	A	T	19: 24,909,026 (GRCm39)		probably null	Het

Other mutations in Zfp418

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01783:Zfp418	APN	7	7,184,448 (GRCm39)	missense	possibly damaging	0.72
IGL02358:Zfp418	APN	7	7,177,690 (GRCm39)	splice site	probably benign
R4355_Zfp418_487	UTSW	7	7,175,161 (GRCm39)	missense	probably benign	0.02
R5592_zfp418_571	UTSW	7	7,184,314 (GRCm39)	missense	possibly damaging	0.72
P0029:Zfp418	UTSW	7	7,177,636 (GRCm39)	missense	probably damaging	0.98
R0018:Zfp418	UTSW	7	7,185,449 (GRCm39)	missense	probably benign	0.06
R0018:Zfp418	UTSW	7	7,185,449 (GRCm39)	missense	probably benign	0.06
R1065:Zfp418	UTSW	7	7,184,561 (GRCm39)	missense	probably benign	0.18
R1168:Zfp418	UTSW	7	7,185,500 (GRCm39)	missense	possibly damaging	0.91
R1660:Zfp418	UTSW	7	7,184,789 (GRCm39)	missense	probably benign	0.04
R1937:Zfp418	UTSW	7	7,185,401 (GRCm39)	missense	possibly damaging	0.71
R2266:Zfp418	UTSW	7	7,185,807 (GRCm39)	missense	probably benign	0.18
R3119:Zfp418	UTSW	7	7,184,688 (GRCm39)	missense	possibly damaging	0.53
R4355:Zfp418	UTSW	7	7,175,161 (GRCm39)	missense	probably benign	0.02
R4539:Zfp418	UTSW	7	7,184,276 (GRCm39)	missense	probably benign	0.18
R4735:Zfp418	UTSW	7	7,185,561 (GRCm39)	missense	probably damaging	0.96
R4756:Zfp418	UTSW	7	7,185,762 (GRCm39)	missense	possibly damaging	0.89
R4763:Zfp418	UTSW	7	7,184,444 (GRCm39)	missense	possibly damaging	0.53
R4810:Zfp418	UTSW	7	7,185,846 (GRCm39)	missense	possibly damaging	0.82
R5347:Zfp418	UTSW	7	7,185,534 (GRCm39)	missense	probably benign	0.40
R5592:Zfp418	UTSW	7	7,184,314 (GRCm39)	missense	possibly damaging	0.72
R5640:Zfp418	UTSW	7	7,184,980 (GRCm39)	nonsense	probably null
R5974:Zfp418	UTSW	7	7,185,199 (GRCm39)	missense	possibly damaging	0.95
R6209:Zfp418	UTSW	7	7,185,096 (GRCm39)	missense	possibly damaging	0.51
R6218:Zfp418	UTSW	7	7,185,627 (GRCm39)	missense	possibly damaging	0.73
R6502:Zfp418	UTSW	7	7,185,599 (GRCm39)	missense	possibly damaging	0.86
R6619:Zfp418	UTSW	7	7,184,895 (GRCm39)	missense	probably damaging	0.98
R7205:Zfp418	UTSW	7	7,184,562 (GRCm39)	missense	probably benign	0.33
R7299:Zfp418	UTSW	7	7,185,827 (GRCm39)	missense	possibly damaging	0.61
R7492:Zfp418	UTSW	7	7,184,396 (GRCm39)	missense	possibly damaging	0.53
R7774:Zfp418	UTSW	7	7,185,776 (GRCm39)	missense	possibly damaging	0.51
R7826:Zfp418	UTSW	7	7,185,668 (GRCm39)	missense	probably benign	0.32
R7974:Zfp418	UTSW	7	7,185,167 (GRCm39)	missense	possibly damaging	0.61
R8002:Zfp418	UTSW	7	7,184,873 (GRCm39)	missense	probably benign	0.04
R8182:Zfp418	UTSW	7	7,184,658 (GRCm39)	missense	probably benign	0.00
R8298:Zfp418	UTSW	7	7,185,814 (GRCm39)	nonsense	probably null
R8773:Zfp418	UTSW	7	7,185,797 (GRCm39)	missense	probably benign	0.06
R9280:Zfp418	UTSW	7	7,184,408 (GRCm39)	missense	possibly damaging	0.53
R9318:Zfp418	UTSW	7	7,185,435 (GRCm39)	missense	probably damaging	0.98
R9404:Zfp418	UTSW	7	7,185,104 (GRCm39)	missense	possibly damaging	0.71
R9648:Zfp418	UTSW	7	7,185,171 (GRCm39)	missense	probably benign	0.29

Posted On

2015-04-16