Incidental Mutation 'IGL02354:Lrrc25'
ID289593
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc25
Ensembl Gene ENSMUSG00000049988
Gene Nameleucine rich repeat containing 25
SynonymsMapa
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL02354
Quality Score
Status
Chromosome8
Chromosomal Location70616155-70621483 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 70617827 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Valine at position 86 (D86V)
Ref Sequence ENSEMBL: ENSMUSP00000049686 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052437] [ENSMUST00000210609]
Predicted Effect probably benign
Transcript: ENSMUST00000052437
AA Change: D86V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000049686
Gene: ENSMUSG00000049988
AA Change: D86V

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
low complexity region 51 62 N/A INTRINSIC
Pfam:LRR_8 65 110 9.6e-8 PFAM
transmembrane domain 169 191 N/A INTRINSIC
low complexity region 192 199 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000210609
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aqp1 A C 6: 55,345,513 L164F possibly damaging Het
Bfsp1 T C 2: 143,831,987 E261G probably damaging Het
Brinp2 A G 1: 158,247,178 C458R probably damaging Het
Cacng3 T G 7: 122,671,946 M58R possibly damaging Het
Cfap43 A T 19: 47,897,413 C254* probably null Het
Cnga1 T C 5: 72,616,718 probably null Het
Dis3 A T 14: 99,079,712 Y765* probably null Het
Dpep1 T A 8: 123,200,218 S260R probably benign Het
Elmod1 A G 9: 53,931,558 L106P probably damaging Het
Fut10 A G 8: 31,201,370 Y81C probably damaging Het
Fzd10 T A 5: 128,601,868 D217E possibly damaging Het
Gap43 T C 16: 42,340,508 probably benign Het
Gigyf1 T C 5: 137,519,727 probably benign Het
Gm1840 T C 8: 5,640,896 noncoding transcript Het
Gpc5 C T 14: 115,133,287 R175* probably null Het
Gpr61 A G 3: 108,150,218 S376P probably damaging Het
Kcna1 C A 6: 126,642,906 Q150H probably damaging Het
Lama5 A T 2: 180,193,884 C1225* probably null Het
Madd A T 2: 91,162,198 V1043E probably benign Het
Mov10 A T 3: 104,804,121 probably benign Het
Mzb1 T A 18: 35,649,197 H46L possibly damaging Het
Nos3 A T 5: 24,367,623 I187F probably damaging Het
Olfr1231 T A 2: 89,303,182 M137L probably benign Het
Olfr473 T A 7: 107,934,277 Y252* probably null Het
Olfr822 A G 10: 130,075,274 Y288C probably damaging Het
Pgap1 T C 1: 54,512,816 T486A probably benign Het
Prdm9 C T 17: 15,562,847 V58M probably damaging Het
Prkd2 A G 7: 16,847,658 Y146C probably damaging Het
Psmd9 G T 5: 123,248,316 R175I probably damaging Het
Pxdn A G 12: 29,999,189 D618G probably damaging Het
Rgs6 A T 12: 82,618,619 probably benign Het
Rrm2 G T 12: 24,711,439 probably benign Het
Sall1 G T 8: 89,033,049 S142R probably benign Het
Shank3 T C 15: 89,504,333 V376A probably damaging Het
Slc5a10 A G 11: 61,719,840 probably null Het
Slfn3 A T 11: 83,213,242 Q313L possibly damaging Het
Snapc4 A G 2: 26,367,307 probably benign Het
Sptbn1 A T 11: 30,110,783 F2062L probably damaging Het
Tbc1d10a T C 11: 4,215,047 V500A probably benign Het
Tcea1 T C 1: 4,896,347 probably benign Het
Thsd7a T C 6: 12,348,193 probably benign Het
Tm9sf4 C T 2: 153,187,650 T173M probably benign Het
Tmtc2 T C 10: 105,271,526 T709A probably benign Het
Zfp385b T C 2: 77,450,303 E97G probably damaging Het
Zim1 A T 7: 6,682,874 probably null Het
Other mutations in Lrrc25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01870:Lrrc25 APN 8 70617787 missense possibly damaging 0.83
IGL02263:Lrrc25 APN 8 70617822 missense probably benign 0.27
IGL02361:Lrrc25 APN 8 70617827 missense probably benign
R0320:Lrrc25 UTSW 8 70618246 missense probably benign 0.00
R1863:Lrrc25 UTSW 8 70617946 missense possibly damaging 0.83
R4816:Lrrc25 UTSW 8 70618076 missense probably benign
R6696:Lrrc25 UTSW 8 70618365 critical splice donor site probably null
R7169:Lrrc25 UTSW 8 70617787 missense probably benign 0.27
R7394:Lrrc25 UTSW 8 70618180 missense possibly damaging 0.60
Posted On2015-04-16