Incidental Mutation 'IGL02354:Fzd10'
ID 289596
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fzd10
Ensembl Gene ENSMUSG00000081683
Gene Name frizzled class receptor 10
Synonyms Fz-10
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02354
Quality Score
Status
Chromosome 5
Chromosomal Location 128678170-128681157 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 128678932 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 217 (D217E)
Ref Sequence ENSEMBL: ENSMUSP00000114114 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117102]
AlphaFold Q8BKG4
Predicted Effect noncoding transcript
Transcript: ENSMUST00000091324
Predicted Effect possibly damaging
Transcript: ENSMUST00000117102
AA Change: D217E

PolyPhen 2 Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000114114
Gene: ENSMUSG00000081683
AA Change: D217E

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
FRI 34 153 7.83e-68 SMART
Frizzled 218 542 2.62e-207 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126472
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134673
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154305
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199981
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aqp1 A C 6: 55,322,498 (GRCm39) L164F possibly damaging Het
Bfsp1 T C 2: 143,673,907 (GRCm39) E261G probably damaging Het
Brinp2 A G 1: 158,074,748 (GRCm39) C458R probably damaging Het
Cacng3 T G 7: 122,271,169 (GRCm39) M58R possibly damaging Het
Cfap43 A T 19: 47,885,852 (GRCm39) C254* probably null Het
Cnga1 T C 5: 72,774,061 (GRCm39) probably null Het
Dis3 A T 14: 99,317,148 (GRCm39) Y765* probably null Het
Dpep1 T A 8: 123,926,957 (GRCm39) S260R probably benign Het
Elmod1 A G 9: 53,838,842 (GRCm39) L106P probably damaging Het
Fut10 A G 8: 31,691,398 (GRCm39) Y81C probably damaging Het
Gap43 T C 16: 42,160,871 (GRCm39) probably benign Het
Gigyf1 T C 5: 137,517,989 (GRCm39) probably benign Het
Gpc5 C T 14: 115,370,699 (GRCm39) R175* probably null Het
Gpi-ps T C 8: 5,690,896 (GRCm39) noncoding transcript Het
Gpr61 A G 3: 108,057,534 (GRCm39) S376P probably damaging Het
Kcna1 C A 6: 126,619,869 (GRCm39) Q150H probably damaging Het
Lama5 A T 2: 179,835,677 (GRCm39) C1225* probably null Het
Lrrc25 A T 8: 71,070,477 (GRCm39) D86V probably benign Het
Madd A T 2: 90,992,543 (GRCm39) V1043E probably benign Het
Mov10 A T 3: 104,711,437 (GRCm39) probably benign Het
Mzb1 T A 18: 35,782,250 (GRCm39) H46L possibly damaging Het
Nos3 A T 5: 24,572,621 (GRCm39) I187F probably damaging Het
Or4c1 T A 2: 89,133,526 (GRCm39) M137L probably benign Het
Or5p53 T A 7: 107,533,484 (GRCm39) Y252* probably null Het
Or6c69c A G 10: 129,911,143 (GRCm39) Y288C probably damaging Het
Pgap1 T C 1: 54,551,975 (GRCm39) T486A probably benign Het
Prdm9 C T 17: 15,783,109 (GRCm39) V58M probably damaging Het
Prkd2 A G 7: 16,581,583 (GRCm39) Y146C probably damaging Het
Psmd9 G T 5: 123,386,379 (GRCm39) R175I probably damaging Het
Pxdn A G 12: 30,049,188 (GRCm39) D618G probably damaging Het
Rgs6 A T 12: 82,665,393 (GRCm39) probably benign Het
Rrm2 G T 12: 24,761,438 (GRCm39) probably benign Het
Sall1 G T 8: 89,759,677 (GRCm39) S142R probably benign Het
Shank3 T C 15: 89,388,536 (GRCm39) V376A probably damaging Het
Slc5a10 A G 11: 61,610,666 (GRCm39) probably null Het
Slfn3 A T 11: 83,104,068 (GRCm39) Q313L possibly damaging Het
Snapc4 A G 2: 26,257,319 (GRCm39) probably benign Het
Sptbn1 A T 11: 30,060,783 (GRCm39) F2062L probably damaging Het
Tbc1d10a T C 11: 4,165,047 (GRCm39) V500A probably benign Het
Tcea1 T C 1: 4,966,570 (GRCm39) probably benign Het
Thsd7a T C 6: 12,348,192 (GRCm39) probably benign Het
Tm9sf4 C T 2: 153,029,570 (GRCm39) T173M probably benign Het
Tmtc2 T C 10: 105,107,387 (GRCm39) T709A probably benign Het
Zfp385b T C 2: 77,280,647 (GRCm39) E97G probably damaging Het
Zim1 A T 7: 6,685,873 (GRCm39) probably null Het
Other mutations in Fzd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Fzd10 APN 5 128,678,592 (GRCm39) missense probably damaging 1.00
IGL02361:Fzd10 APN 5 128,678,932 (GRCm39) missense possibly damaging 0.89
IGL03088:Fzd10 APN 5 128,679,669 (GRCm39) missense possibly damaging 0.81
R0530:Fzd10 UTSW 5 128,679,077 (GRCm39) missense probably damaging 1.00
R0645:Fzd10 UTSW 5 128,679,662 (GRCm39) missense possibly damaging 0.94
R1515:Fzd10 UTSW 5 128,679,623 (GRCm39) missense probably damaging 1.00
R3930:Fzd10 UTSW 5 128,679,476 (GRCm39) missense probably damaging 1.00
R4467:Fzd10 UTSW 5 128,678,340 (GRCm39) missense probably benign 0.01
R4976:Fzd10 UTSW 5 128,679,178 (GRCm39) nonsense probably null
R5156:Fzd10 UTSW 5 128,678,366 (GRCm39) missense possibly damaging 0.68
R5202:Fzd10 UTSW 5 128,679,180 (GRCm39) missense possibly damaging 0.78
R5874:Fzd10 UTSW 5 128,678,364 (GRCm39) missense probably benign 0.41
R6238:Fzd10 UTSW 5 128,679,995 (GRCm39) missense probably damaging 0.99
R6921:Fzd10 UTSW 5 128,678,646 (GRCm39) missense probably damaging 0.99
R7684:Fzd10 UTSW 5 128,678,480 (GRCm39) missense possibly damaging 0.73
R8093:Fzd10 UTSW 5 128,679,303 (GRCm39) missense probably benign 0.14
R9011:Fzd10 UTSW 5 128,679,369 (GRCm39) missense probably damaging 1.00
R9013:Fzd10 UTSW 5 128,679,369 (GRCm39) missense probably damaging 1.00
R9014:Fzd10 UTSW 5 128,679,369 (GRCm39) missense probably damaging 1.00
R9332:Fzd10 UTSW 5 128,678,316 (GRCm39) missense possibly damaging 0.92
R9603:Fzd10 UTSW 5 128,678,771 (GRCm39) missense probably benign 0.00
Z1088:Fzd10 UTSW 5 128,678,310 (GRCm39) missense probably damaging 0.98
Posted On 2015-04-16