Incidental Mutation 'IGL02355:Sik2'
ID 289643
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sik2
Ensembl Gene ENSMUSG00000037112
Gene Name salt inducible kinase 2
Synonyms G630080D20Rik, Snf1lk2
Accession Numbers
Essential gene? Possibly essential (E-score: 0.719) question?
Stock # IGL02355
Quality Score
Status
Chromosome 9
Chromosomal Location 50804101-50920373 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 50828903 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Stop codon at position 176 (W176*)
Ref Sequence ENSEMBL: ENSMUSP00000134936 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041375] [ENSMUST00000176491] [ENSMUST00000176663] [ENSMUST00000176824]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000041375
AA Change: W176*
SMART Domains Protein: ENSMUSP00000038761
Gene: ENSMUSG00000037112
AA Change: W176*

DomainStartEndE-ValueType
S_TKc 20 271 4.63e-101 SMART
low complexity region 454 464 N/A INTRINSIC
low complexity region 643 664 N/A INTRINSIC
low complexity region 708 731 N/A INTRINSIC
low complexity region 800 842 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000176491
AA Change: W176*
SMART Domains Protein: ENSMUSP00000134954
Gene: ENSMUSG00000037112
AA Change: W176*

DomainStartEndE-ValueType
S_TKc 20 271 4.63e-101 SMART
low complexity region 454 464 N/A INTRINSIC
low complexity region 643 664 N/A INTRINSIC
low complexity region 708 731 N/A INTRINSIC
low complexity region 800 842 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000176663
AA Change: W176*
SMART Domains Protein: ENSMUSP00000135376
Gene: ENSMUSG00000037112
AA Change: W176*

DomainStartEndE-ValueType
S_TKc 20 271 4.63e-101 SMART
low complexity region 454 464 N/A INTRINSIC
low complexity region 643 664 N/A INTRINSIC
low complexity region 708 731 N/A INTRINSIC
low complexity region 800 842 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000176824
AA Change: W176*
SMART Domains Protein: ENSMUSP00000134936
Gene: ENSMUSG00000037112
AA Change: W176*

DomainStartEndE-ValueType
S_TKc 20 271 4.63e-101 SMART
low complexity region 454 464 N/A INTRINSIC
low complexity region 643 664 N/A INTRINSIC
low complexity region 708 731 N/A INTRINSIC
low complexity region 800 842 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice heterozygous for a knock-out allele exhibit darkened hair color in an agouti background. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam3 C A 8: 25,187,207 (GRCm39) C428F probably damaging Het
Alas1 T C 9: 106,113,838 (GRCm39) Y469C probably damaging Het
Asxl1 C T 2: 153,243,706 (GRCm39) L1419F probably benign Het
Bcan C T 3: 87,901,449 (GRCm39) D418N possibly damaging Het
Cdc42bpg A G 19: 6,360,839 (GRCm39) D199G possibly damaging Het
Chst15 T C 7: 131,868,401 (GRCm39) N340D probably benign Het
Col12a1 T G 9: 79,537,993 (GRCm39) probably benign Het
Cyp2c67 T A 19: 39,631,849 (GRCm39) H116L probably benign Het
Cyp2c67 G A 19: 39,605,826 (GRCm39) R357* probably null Het
Ears2 T C 7: 121,643,773 (GRCm39) D395G probably benign Het
Fam227a A T 15: 79,528,139 (GRCm39) probably benign Het
Fap A G 2: 62,403,842 (GRCm39) V11A probably benign Het
Ganc A G 2: 120,264,238 (GRCm39) D397G probably damaging Het
Gjb6 C A 14: 57,361,752 (GRCm39) G170C possibly damaging Het
Gria2 A T 3: 80,614,244 (GRCm39) W599R probably damaging Het
Gvin-ps5 T C 7: 105,929,480 (GRCm39) noncoding transcript Het
Ighv1-64 A G 12: 115,471,236 (GRCm39) S94P probably benign Het
Kifc3 C T 8: 95,836,507 (GRCm39) A85T probably damaging Het
Lifr G A 15: 7,194,174 (GRCm39) probably null Het
Lonp2 T G 8: 87,350,874 (GRCm39) S21R probably benign Het
Nxpe3 A G 16: 55,710,949 (GRCm39) V30A probably benign Het
Olfml1 T C 7: 107,167,010 (GRCm39) V13A probably benign Het
Or10w1 T C 19: 13,632,597 (GRCm39) V268A probably benign Het
Or1af1 A G 2: 37,109,681 (GRCm39) Y60C probably damaging Het
Pcnt G A 10: 76,210,996 (GRCm39) Q2376* probably null Het
Pglyrp2 A G 17: 32,635,996 (GRCm39) L380P probably damaging Het
Plin3 A G 17: 56,593,636 (GRCm39) V26A probably benign Het
Potefam1 T C 2: 111,041,996 (GRCm39) probably benign Het
Pramel25 A G 4: 143,519,580 (GRCm39) S114G probably damaging Het
Rims1 A G 1: 22,522,288 (GRCm39) I470T probably damaging Het
Rora T C 9: 69,281,374 (GRCm39) Y329H probably damaging Het
Scnn1b G A 7: 121,516,770 (GRCm39) R503H probably damaging Het
Sec14l1 A G 11: 117,035,675 (GRCm39) D237G possibly damaging Het
Selplg A G 5: 113,957,467 (GRCm39) S280P probably benign Het
Serpina12 A G 12: 104,004,140 (GRCm39) L164P probably benign Het
Slc2a1 T C 4: 118,993,612 (GRCm39) F483S possibly damaging Het
Speg A G 1: 75,400,559 (GRCm39) D2573G possibly damaging Het
Stil C T 4: 114,867,308 (GRCm39) S239L probably damaging Het
Tmem94 C A 11: 115,685,571 (GRCm39) S941R probably damaging Het
Tnfrsf11b T A 15: 54,115,778 (GRCm39) D273V probably damaging Het
Tns2 A G 15: 102,020,725 (GRCm39) T864A probably benign Het
Zfpm2 A G 15: 40,962,890 (GRCm39) H184R probably damaging Het
Other mutations in Sik2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01366:Sik2 APN 9 50,818,763 (GRCm39) missense probably damaging 0.96
IGL01552:Sik2 APN 9 50,828,822 (GRCm39) splice site probably benign
IGL02175:Sik2 APN 9 50,806,909 (GRCm39) nonsense probably null
IGL02362:Sik2 APN 9 50,828,903 (GRCm39) nonsense probably null
IGL03197:Sik2 APN 9 50,807,073 (GRCm39) missense probably damaging 1.00
R0066:Sik2 UTSW 9 50,909,833 (GRCm39) missense probably benign 0.18
R0066:Sik2 UTSW 9 50,909,833 (GRCm39) missense probably benign 0.18
R0109:Sik2 UTSW 9 50,810,775 (GRCm39) missense possibly damaging 0.50
R0109:Sik2 UTSW 9 50,810,775 (GRCm39) missense possibly damaging 0.50
R0416:Sik2 UTSW 9 50,906,932 (GRCm39) missense probably damaging 1.00
R0648:Sik2 UTSW 9 50,810,045 (GRCm39) missense probably benign 0.26
R0714:Sik2 UTSW 9 50,818,736 (GRCm39) missense probably benign 0.13
R1472:Sik2 UTSW 9 50,920,111 (GRCm39) missense probably damaging 1.00
R1592:Sik2 UTSW 9 50,906,971 (GRCm39) missense probably damaging 1.00
R1899:Sik2 UTSW 9 50,906,974 (GRCm39) splice site probably benign
R2032:Sik2 UTSW 9 50,906,947 (GRCm39) missense probably damaging 1.00
R2079:Sik2 UTSW 9 50,818,706 (GRCm39) critical splice donor site probably null
R2853:Sik2 UTSW 9 50,809,597 (GRCm39) missense probably damaging 1.00
R4085:Sik2 UTSW 9 50,846,685 (GRCm39) intron probably benign
R4567:Sik2 UTSW 9 50,909,876 (GRCm39) missense probably damaging 1.00
R5098:Sik2 UTSW 9 50,906,891 (GRCm39) intron probably benign
R5176:Sik2 UTSW 9 50,810,703 (GRCm39) missense probably benign 0.02
R5640:Sik2 UTSW 9 50,826,806 (GRCm39) missense possibly damaging 0.93
R5682:Sik2 UTSW 9 50,828,382 (GRCm39) missense probably damaging 1.00
R5779:Sik2 UTSW 9 50,807,145 (GRCm39) missense probably benign
R5935:Sik2 UTSW 9 50,828,431 (GRCm39) missense probably damaging 1.00
R5997:Sik2 UTSW 9 50,806,642 (GRCm39) critical splice donor site probably null
R6664:Sik2 UTSW 9 50,846,757 (GRCm39) missense probably damaging 1.00
R6787:Sik2 UTSW 9 50,909,834 (GRCm39) missense possibly damaging 0.67
R6980:Sik2 UTSW 9 50,808,755 (GRCm39) missense probably benign 0.00
R7057:Sik2 UTSW 9 50,909,861 (GRCm39) missense probably damaging 1.00
R7064:Sik2 UTSW 9 50,818,720 (GRCm39) missense probably damaging 0.99
R7165:Sik2 UTSW 9 50,828,397 (GRCm39) missense probably damaging 1.00
R7892:Sik2 UTSW 9 50,920,132 (GRCm39) missense probably damaging 0.98
R8252:Sik2 UTSW 9 50,828,415 (GRCm39) missense possibly damaging 0.89
R8893:Sik2 UTSW 9 50,810,026 (GRCm39) missense probably damaging 1.00
R8987:Sik2 UTSW 9 50,806,647 (GRCm39) missense probably benign
R9747:Sik2 UTSW 9 50,810,058 (GRCm39) missense possibly damaging 0.95
R9753:Sik2 UTSW 9 50,807,139 (GRCm39) missense probably damaging 0.96
Posted On 2015-04-16