Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02278:Zfp850'

289768

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp850

Ensembl Gene

ENSMUSG00000096916

Gene Name

zinc finger protein 850

Synonyms

C130069I09Rik, Gm4636

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL02278

Quality Score

Status

Chromosome

Chromosomal Location

27684279-27713540 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 27707822 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 7 (Q7L)

Ref Sequence

ENSEMBL: ENSMUSP00000141063 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000180024] [ENSMUST00000180502]

AlphaFold

J3QPC5

Predicted Effect

probably damaging
Transcript: ENSMUST00000180024
AA Change: Q7L

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000137192
Gene: ENSMUSG00000096916
AA Change: Q7L

Domain	Start	End	E-Value	Type
KRAB	14	75	1.56e-34	SMART
ZnF_C2H2	172	194	7.18e1	SMART
ZnF_C2H2	200	222	3.63e-3	SMART
ZnF_C2H2	228	250	8.94e-3	SMART
ZnF_C2H2	256	278	7.49e-5	SMART
ZnF_C2H2	313	335	1.01e-1	SMART
ZnF_C2H2	341	363	4.4e-2	SMART
ZnF_C2H2	369	391	7.37e-4	SMART
ZnF_C2H2	397	419	8.47e-4	SMART
ZnF_C2H2	425	447	1.92e-2	SMART
ZnF_C2H2	453	475	2.99e-4	SMART
ZnF_C2H2	481	503	7.78e-3	SMART
ZnF_C2H2	509	531	1.95e-3	SMART
ZnF_C2H2	537	559	1.92e-2	SMART
ZnF_C2H2	565	587	2.99e-4	SMART
ZnF_C2H2	593	615	1.79e-2	SMART
ZnF_C2H2	621	643	7.37e-4	SMART
ZnF_C2H2	649	671	4.4e-2	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000180502
AA Change: Q7L

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000141063
Gene: ENSMUSG00000096916
AA Change: Q7L

Domain	Start	End	E-Value	Type
KRAB	14	75	6.5e-37	SMART
ZnF_C2H2	172	194	3e-1	SMART
ZnF_C2H2	200	222	1.5e-5	SMART
ZnF_C2H2	228	250	3.8e-5	SMART
ZnF_C2H2	256	274	2.5e-1	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 8 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bbs4	T	A	9: 59,248,451 (GRCm39)	Q84L	possibly damaging	Het
Cemip	A	T	7: 83,586,646 (GRCm39)	W1303R	probably damaging	Het
Edrf1	T	C	7: 133,258,729 (GRCm39)	S702P	probably benign	Het
Muc4	C	A	16: 32,754,529 (GRCm38)	H1468N	probably benign	Het
Nav1	G	A	1: 135,391,452 (GRCm39)		probably benign	Het
Pramel5	A	G	4: 143,998,121 (GRCm39)	L374P	probably damaging	Het
Slc2a2	T	C	3: 28,771,604 (GRCm39)	I178T	probably damaging	Het
Tsnaxip1	A	G	8: 106,554,413 (GRCm39)		probably benign	Het

Other mutations in Zfp850

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0610:Zfp850	UTSW	7	27,688,819 (GRCm39)	missense	probably damaging	0.99
R0690:Zfp850	UTSW	7	27,684,642 (GRCm39)	missense	possibly damaging	0.67
R0711:Zfp850	UTSW	7	27,689,698 (GRCm39)	missense	probably benign	0.00
R1310:Zfp850	UTSW	7	27,688,884 (GRCm39)	missense	probably benign	0.40
R1594:Zfp850	UTSW	7	27,688,816 (GRCm39)	missense	probably benign	0.00
R1771:Zfp850	UTSW	7	27,684,700 (GRCm39)	nonsense	probably null
R2189:Zfp850	UTSW	7	27,688,480 (GRCm39)	missense	probably benign	0.02
R2192:Zfp850	UTSW	7	27,684,620 (GRCm39)	missense	probably damaging	1.00
R2417:Zfp850	UTSW	7	27,688,608 (GRCm39)	missense	possibly damaging	0.54
R4321:Zfp850	UTSW	7	27,688,825 (GRCm39)	missense	probably damaging	0.99
R4770:Zfp850	UTSW	7	27,684,411 (GRCm39)	splice site	probably null
R4970:Zfp850	UTSW	7	27,689,658 (GRCm39)	nonsense	probably null
R5112:Zfp850	UTSW	7	27,689,658 (GRCm39)	nonsense	probably null
R5166:Zfp850	UTSW	7	27,689,781 (GRCm39)	nonsense	probably null
R5303:Zfp850	UTSW	7	27,707,838 (GRCm39)	missense	probably damaging	1.00
R5315:Zfp850	UTSW	7	27,689,743 (GRCm39)	missense	probably benign	0.02
R5496:Zfp850	UTSW	7	27,706,771 (GRCm39)	missense	probably damaging	0.98
R5547:Zfp850	UTSW	7	27,688,844 (GRCm39)	missense	probably damaging	1.00
R5677:Zfp850	UTSW	7	27,688,513 (GRCm39)	missense	probably damaging	1.00
R5927:Zfp850	UTSW	7	27,689,620 (GRCm39)	missense	probably benign	0.17
R6654:Zfp850	UTSW	7	27,684,640 (GRCm39)	nonsense	probably null
R6950:Zfp850	UTSW	7	27,689,939 (GRCm39)	missense	possibly damaging	0.86
R6987:Zfp850	UTSW	7	27,689,426 (GRCm39)	missense	probably damaging	1.00
R6990:Zfp850	UTSW	7	27,689,801 (GRCm39)	missense	probably benign	0.09
R7640:Zfp850	UTSW	7	27,688,634 (GRCm39)	missense	probably benign	0.05
R7856:Zfp850	UTSW	7	27,689,899 (GRCm39)	missense	probably benign	0.02
R9498:Zfp850	UTSW	7	27,689,275 (GRCm39)	missense	possibly damaging	0.88
R9506:Zfp850	UTSW	7	27,688,987 (GRCm39)	missense	possibly damaging	0.82
Z1186:Zfp850	UTSW	7	27,689,704 (GRCm39)	missense	probably benign	0.00
Z1186:Zfp850	UTSW	7	27,688,549 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16