Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02282:Vmn2r37'

289856

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r37

Ensembl Gene

ENSMUSG00000066828

Gene Name

vomeronasal 2, receptor 37

Synonyms

V2r14

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

IGL02282

Quality Score

Status

Chromosome

Chromosomal Location

9208548-9226652 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 9209761 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 584 (S584P)

Ref Sequence

ENSEMBL: ENSMUSP00000072566 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072787]

AlphaFold

F8VQD3

Predicted Effect

probably benign
Transcript: ENSMUST00000072787
AA Change: S584P

PolyPhen 2 Score 0.194 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000072566
Gene: ENSMUSG00000066828
AA Change: S584P

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	157	469	2.9e-26	PFAM
Pfam:NCD3G	512	563	1.1e-16	PFAM
Pfam:7tm_3	550	783	1.7e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	A	G	19: 8,983,351 (GRCm39)	D1545G	probably damaging	Het
Baiap3	A	C	17: 25,468,351 (GRCm39)	D234E	probably benign	Het
Bltp2	C	T	11: 78,175,054 (GRCm39)	P1730S	probably benign	Het
Cand1	T	A	10: 119,046,614 (GRCm39)	T959S	probably benign	Het
Ctdspl2	A	G	2: 121,807,959 (GRCm39)		probably benign	Het
Cyp2a4	A	C	7: 26,008,472 (GRCm39)	M205L	probably benign	Het
Dlx5	G	A	6: 6,881,762 (GRCm39)	A42V	probably damaging	Het
Dnah7a	A	G	1: 53,682,669 (GRCm39)	I267T	possibly damaging	Het
Dnajb6	A	G	5: 29,957,416 (GRCm39)	D66G	probably damaging	Het
Fgf8	T	C	19: 45,725,529 (GRCm39)	H201R	possibly damaging	Het
Gpc1	A	G	1: 92,785,689 (GRCm39)	K460E	probably damaging	Het
Gzme	A	T	14: 56,355,826 (GRCm39)	L162Q	probably damaging	Het
Ik	G	A	18: 36,878,697 (GRCm39)	G17D	probably damaging	Het
Il4	G	A	11: 53,509,001 (GRCm39)	T59M	probably damaging	Het
Kcnh3	G	T	15: 99,125,924 (GRCm39)		probably null	Het
Mill1	G	T	7: 17,997,129 (GRCm39)		probably null	Het
Npbwr1	A	T	1: 5,987,184 (GRCm39)	M110K	possibly damaging	Het
Opalin	A	T	19: 41,054,943 (GRCm39)	S84T	probably benign	Het
Or10w1	T	A	19: 13,632,622 (GRCm39)	D276E	probably damaging	Het
Or7g30	A	G	9: 19,352,914 (GRCm39)	Y235C	probably benign	Het
Or8b35	A	T	9: 37,904,318 (GRCm39)	I177F	probably damaging	Het
Pcdhb11	T	C	18: 37,556,881 (GRCm39)	L737P	probably damaging	Het
Phip	G	A	9: 82,795,743 (GRCm39)	S626L	probably benign	Het
Ppl	T	C	16: 4,919,322 (GRCm39)	D435G	probably damaging	Het
Prss37	A	G	6: 40,492,317 (GRCm39)	V178A	possibly damaging	Het
Ptpn7	A	G	1: 135,062,572 (GRCm39)	I104V	probably damaging	Het
Ptprn	A	G	1: 75,229,800 (GRCm39)	Y700H	probably damaging	Het
Rab11fip5	T	A	6: 85,314,534 (GRCm39)	T555S	probably damaging	Het
Rfwd3	A	T	8: 112,020,614 (GRCm39)		probably benign	Het
Robo1	G	A	16: 72,539,026 (GRCm39)	R41H	probably damaging	Het
Rps3	A	G	7: 99,128,479 (GRCm39)		probably null	Het
Ruvbl2	G	A	7: 45,074,589 (GRCm39)	T183I	probably benign	Het
Sema4c	A	T	1: 36,589,284 (GRCm39)		probably null	Het
Shoc1	A	C	4: 59,111,114 (GRCm39)	Y53D	unknown	Het
Taar8b	T	A	10: 23,967,453 (GRCm39)	K247I	possibly damaging	Het
Tacr3	A	T	3: 134,566,834 (GRCm39)	I236F	probably benign	Het
Ttc21b	A	G	2: 66,022,081 (GRCm39)	I1168T	probably damaging	Het
Ttc9b	A	T	7: 27,355,336 (GRCm39)	D202V	probably damaging	Het
Vmn2r26	T	G	6: 124,038,584 (GRCm39)	C720G	probably damaging	Het
Wnk2	T	A	13: 49,221,601 (GRCm39)	D1208V	probably damaging	Het
Zfp988	T	A	4: 147,416,125 (GRCm39)	C186*	probably null	Het
Zp3	A	G	5: 136,013,205 (GRCm39)	N179S	possibly damaging	Het

Other mutations in Vmn2r37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01346:Vmn2r37	APN	7	9,209,680 (GRCm39)	missense	probably benign	0.05
IGL01909:Vmn2r37	APN	7	9,219,032 (GRCm39)	nonsense	probably null
IGL02281:Vmn2r37	APN	7	9,220,881 (GRCm39)	missense	possibly damaging	0.95
IGL02513:Vmn2r37	APN	7	9,220,934 (GRCm39)	missense	probably benign	0.14
R0136:Vmn2r37	UTSW	7	9,220,782 (GRCm39)	nonsense	probably null
R2051:Vmn2r37	UTSW	7	9,220,792 (GRCm39)	missense	probably damaging	1.00
R2262:Vmn2r37	UTSW	7	9,220,943 (GRCm39)	missense	probably damaging	0.99
R3158:Vmn2r37	UTSW	7	9,220,713 (GRCm39)	missense	probably benign	0.03
R4084:Vmn2r37	UTSW	7	9,218,984 (GRCm39)	missense	probably benign
R4114:Vmn2r37	UTSW	7	9,213,092 (GRCm39)	critical splice acceptor site	probably null
R5231:Vmn2r37	UTSW	7	9,209,594 (GRCm39)	missense	possibly damaging	0.94
R5462:Vmn2r37	UTSW	7	9,220,973 (GRCm39)	missense	probably damaging	1.00
R6437:Vmn2r37	UTSW	7	9,220,850 (GRCm39)	missense	probably damaging	0.98
R7104:Vmn2r37	UTSW	7	9,219,045 (GRCm39)	missense	probably damaging	1.00
R7116:Vmn2r37	UTSW	7	9,220,898 (GRCm39)	missense	probably benign	0.00
R7381:Vmn2r37	UTSW	7	9,213,032 (GRCm39)	missense	probably benign	0.21
R8775:Vmn2r37	UTSW	7	9,218,991 (GRCm39)	nonsense	probably null
R8775-TAIL:Vmn2r37	UTSW	7	9,218,991 (GRCm39)	nonsense	probably null
R8869:Vmn2r37	UTSW	7	9,209,854 (GRCm39)	missense	possibly damaging	0.50
R8884:Vmn2r37	UTSW	7	9,218,916 (GRCm39)	missense	probably benign
RF004:Vmn2r37	UTSW	7	9,220,686 (GRCm39)	missense	probably damaging	0.97
Z1177:Vmn2r37	UTSW	7	9,212,996 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16