Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02282:Prss37'

289857

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss37

Ensembl Gene

ENSMUSG00000029909

Gene Name

serine protease 37

Synonyms

1700016G05Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02282

Quality Score

Status

Chromosome

Chromosomal Location

40491757-40496418 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 40492317 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 178 (V178A)

Ref Sequence

ENSEMBL: ENSMUSP00000031967 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031967]

AlphaFold

Q9DAA4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000031967
AA Change: V178A

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000031967
Gene: ENSMUSG00000029909
AA Change: V178A

Domain	Start	End	E-Value	Type
Tryp_SPc	15	228	2.31e-15	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148195

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with impaired zona binding and migration from the uterus into the oviduct. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	A	G	19: 8,983,351 (GRCm39)	D1545G	probably damaging	Het
Baiap3	A	C	17: 25,468,351 (GRCm39)	D234E	probably benign	Het
Bltp2	C	T	11: 78,175,054 (GRCm39)	P1730S	probably benign	Het
Cand1	T	A	10: 119,046,614 (GRCm39)	T959S	probably benign	Het
Ctdspl2	A	G	2: 121,807,959 (GRCm39)		probably benign	Het
Cyp2a4	A	C	7: 26,008,472 (GRCm39)	M205L	probably benign	Het
Dlx5	G	A	6: 6,881,762 (GRCm39)	A42V	probably damaging	Het
Dnah7a	A	G	1: 53,682,669 (GRCm39)	I267T	possibly damaging	Het
Dnajb6	A	G	5: 29,957,416 (GRCm39)	D66G	probably damaging	Het
Fgf8	T	C	19: 45,725,529 (GRCm39)	H201R	possibly damaging	Het
Gpc1	A	G	1: 92,785,689 (GRCm39)	K460E	probably damaging	Het
Gzme	A	T	14: 56,355,826 (GRCm39)	L162Q	probably damaging	Het
Ik	G	A	18: 36,878,697 (GRCm39)	G17D	probably damaging	Het
Il4	G	A	11: 53,509,001 (GRCm39)	T59M	probably damaging	Het
Kcnh3	G	T	15: 99,125,924 (GRCm39)		probably null	Het
Mill1	G	T	7: 17,997,129 (GRCm39)		probably null	Het
Npbwr1	A	T	1: 5,987,184 (GRCm39)	M110K	possibly damaging	Het
Opalin	A	T	19: 41,054,943 (GRCm39)	S84T	probably benign	Het
Or10w1	T	A	19: 13,632,622 (GRCm39)	D276E	probably damaging	Het
Or7g30	A	G	9: 19,352,914 (GRCm39)	Y235C	probably benign	Het
Or8b35	A	T	9: 37,904,318 (GRCm39)	I177F	probably damaging	Het
Pcdhb11	T	C	18: 37,556,881 (GRCm39)	L737P	probably damaging	Het
Phip	G	A	9: 82,795,743 (GRCm39)	S626L	probably benign	Het
Ppl	T	C	16: 4,919,322 (GRCm39)	D435G	probably damaging	Het
Ptpn7	A	G	1: 135,062,572 (GRCm39)	I104V	probably damaging	Het
Ptprn	A	G	1: 75,229,800 (GRCm39)	Y700H	probably damaging	Het
Rab11fip5	T	A	6: 85,314,534 (GRCm39)	T555S	probably damaging	Het
Rfwd3	A	T	8: 112,020,614 (GRCm39)		probably benign	Het
Robo1	G	A	16: 72,539,026 (GRCm39)	R41H	probably damaging	Het
Rps3	A	G	7: 99,128,479 (GRCm39)		probably null	Het
Ruvbl2	G	A	7: 45,074,589 (GRCm39)	T183I	probably benign	Het
Sema4c	A	T	1: 36,589,284 (GRCm39)		probably null	Het
Shoc1	A	C	4: 59,111,114 (GRCm39)	Y53D	unknown	Het
Taar8b	T	A	10: 23,967,453 (GRCm39)	K247I	possibly damaging	Het
Tacr3	A	T	3: 134,566,834 (GRCm39)	I236F	probably benign	Het
Ttc21b	A	G	2: 66,022,081 (GRCm39)	I1168T	probably damaging	Het
Ttc9b	A	T	7: 27,355,336 (GRCm39)	D202V	probably damaging	Het
Vmn2r26	T	G	6: 124,038,584 (GRCm39)	C720G	probably damaging	Het
Vmn2r37	A	G	7: 9,209,761 (GRCm39)	S584P	probably benign	Het
Wnk2	T	A	13: 49,221,601 (GRCm39)	D1208V	probably damaging	Het
Zfp988	T	A	4: 147,416,125 (GRCm39)	C186*	probably null	Het
Zp3	A	G	5: 136,013,205 (GRCm39)	N179S	possibly damaging	Het

Other mutations in Prss37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03110:Prss37	APN	6	40,495,984 (GRCm39)	missense	probably benign	0.00
R0201:Prss37	UTSW	6	40,493,283 (GRCm39)	missense	probably damaging	1.00
R0350:Prss37	UTSW	6	40,491,893 (GRCm39)	missense	probably damaging	0.99
R2118:Prss37	UTSW	6	40,492,294 (GRCm39)	nonsense	probably null
R2120:Prss37	UTSW	6	40,492,294 (GRCm39)	nonsense	probably null
R2124:Prss37	UTSW	6	40,492,294 (GRCm39)	nonsense	probably null
R2504:Prss37	UTSW	6	40,494,760 (GRCm39)	splice site	probably null
R4711:Prss37	UTSW	6	40,492,381 (GRCm39)	missense	probably benign	0.21
R4938:Prss37	UTSW	6	40,491,917 (GRCm39)	missense	possibly damaging	0.81
R4983:Prss37	UTSW	6	40,493,070 (GRCm39)	missense	probably benign	0.01
R6652:Prss37	UTSW	6	40,496,090 (GRCm39)	start gained	probably benign
R8111:Prss37	UTSW	6	40,494,747 (GRCm39)	missense	probably benign	0.00
R8425:Prss37	UTSW	6	40,493,052 (GRCm39)	nonsense	probably null
R8859:Prss37	UTSW	6	40,491,897 (GRCm39)	missense	probably damaging	1.00
R9297:Prss37	UTSW	6	40,491,909 (GRCm39)	missense	probably damaging	1.00
R9318:Prss37	UTSW	6	40,491,909 (GRCm39)	missense	probably damaging	1.00
R9778:Prss37	UTSW	6	40,494,713 (GRCm39)	missense	probably damaging	0.99
X0063:Prss37	UTSW	6	40,493,149 (GRCm39)	missense	possibly damaging	0.65

Posted On

2015-04-16