Incidental Mutation 'IGL02282:Or8b35'
ID 289871
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8b35
Ensembl Gene ENSMUSG00000060583
Gene Name olfactory receptor family 8 subfamily B member 35
Synonyms Olfr881, MOR162-7, GA_x6K02T2PVTD-31676771-31677700
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # IGL02282
Quality Score
Status
Chromosome 9
Chromosomal Location 37903788-37904735 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 37904318 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 177 (I177F)
Ref Sequence ENSEMBL: ENSMUSP00000074193 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074611] [ENSMUST00000212489]
AlphaFold Q8VF63
Predicted Effect probably damaging
Transcript: ENSMUST00000074611
AA Change: I177F

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000074193
Gene: ENSMUSG00000060583
AA Change: I177F

DomainStartEndE-ValueType
Pfam:7tm_4 36 311 4.6e-46 PFAM
Pfam:7tm_1 46 293 1.4e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000212489
AA Change: I172F

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak A G 19: 8,983,351 (GRCm39) D1545G probably damaging Het
Baiap3 A C 17: 25,468,351 (GRCm39) D234E probably benign Het
Bltp2 C T 11: 78,175,054 (GRCm39) P1730S probably benign Het
Cand1 T A 10: 119,046,614 (GRCm39) T959S probably benign Het
Ctdspl2 A G 2: 121,807,959 (GRCm39) probably benign Het
Cyp2a4 A C 7: 26,008,472 (GRCm39) M205L probably benign Het
Dlx5 G A 6: 6,881,762 (GRCm39) A42V probably damaging Het
Dnah7a A G 1: 53,682,669 (GRCm39) I267T possibly damaging Het
Dnajb6 A G 5: 29,957,416 (GRCm39) D66G probably damaging Het
Fgf8 T C 19: 45,725,529 (GRCm39) H201R possibly damaging Het
Gpc1 A G 1: 92,785,689 (GRCm39) K460E probably damaging Het
Gzme A T 14: 56,355,826 (GRCm39) L162Q probably damaging Het
Ik G A 18: 36,878,697 (GRCm39) G17D probably damaging Het
Il4 G A 11: 53,509,001 (GRCm39) T59M probably damaging Het
Kcnh3 G T 15: 99,125,924 (GRCm39) probably null Het
Mill1 G T 7: 17,997,129 (GRCm39) probably null Het
Npbwr1 A T 1: 5,987,184 (GRCm39) M110K possibly damaging Het
Opalin A T 19: 41,054,943 (GRCm39) S84T probably benign Het
Or10w1 T A 19: 13,632,622 (GRCm39) D276E probably damaging Het
Or7g30 A G 9: 19,352,914 (GRCm39) Y235C probably benign Het
Pcdhb11 T C 18: 37,556,881 (GRCm39) L737P probably damaging Het
Phip G A 9: 82,795,743 (GRCm39) S626L probably benign Het
Ppl T C 16: 4,919,322 (GRCm39) D435G probably damaging Het
Prss37 A G 6: 40,492,317 (GRCm39) V178A possibly damaging Het
Ptpn7 A G 1: 135,062,572 (GRCm39) I104V probably damaging Het
Ptprn A G 1: 75,229,800 (GRCm39) Y700H probably damaging Het
Rab11fip5 T A 6: 85,314,534 (GRCm39) T555S probably damaging Het
Rfwd3 A T 8: 112,020,614 (GRCm39) probably benign Het
Robo1 G A 16: 72,539,026 (GRCm39) R41H probably damaging Het
Rps3 A G 7: 99,128,479 (GRCm39) probably null Het
Ruvbl2 G A 7: 45,074,589 (GRCm39) T183I probably benign Het
Sema4c A T 1: 36,589,284 (GRCm39) probably null Het
Shoc1 A C 4: 59,111,114 (GRCm39) Y53D unknown Het
Taar8b T A 10: 23,967,453 (GRCm39) K247I possibly damaging Het
Tacr3 A T 3: 134,566,834 (GRCm39) I236F probably benign Het
Ttc21b A G 2: 66,022,081 (GRCm39) I1168T probably damaging Het
Ttc9b A T 7: 27,355,336 (GRCm39) D202V probably damaging Het
Vmn2r26 T G 6: 124,038,584 (GRCm39) C720G probably damaging Het
Vmn2r37 A G 7: 9,209,761 (GRCm39) S584P probably benign Het
Wnk2 T A 13: 49,221,601 (GRCm39) D1208V probably damaging Het
Zfp988 T A 4: 147,416,125 (GRCm39) C186* probably null Het
Zp3 A G 5: 136,013,205 (GRCm39) N179S possibly damaging Het
Other mutations in Or8b35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01882:Or8b35 APN 9 37,903,856 (GRCm39) missense probably damaging 1.00
IGL02714:Or8b35 APN 9 37,904,382 (GRCm39) missense possibly damaging 0.83
R0308:Or8b35 UTSW 9 37,904,141 (GRCm39) missense probably benign 0.01
R0486:Or8b35 UTSW 9 37,903,998 (GRCm39) missense possibly damaging 0.72
R0504:Or8b35 UTSW 9 37,904,438 (GRCm39) missense probably benign 0.05
R1939:Or8b35 UTSW 9 37,904,385 (GRCm39) missense probably benign 0.12
R4669:Or8b35 UTSW 9 37,904,381 (GRCm39) missense possibly damaging 0.83
R5377:Or8b35 UTSW 9 37,903,908 (GRCm39) missense probably benign 0.13
R5468:Or8b35 UTSW 9 37,904,307 (GRCm39) missense probably damaging 1.00
R5601:Or8b35 UTSW 9 37,904,010 (GRCm39) missense possibly damaging 0.79
R6799:Or8b35 UTSW 9 37,904,478 (GRCm39) missense possibly damaging 0.79
R7212:Or8b35 UTSW 9 37,904,253 (GRCm39) missense possibly damaging 0.47
R7648:Or8b35 UTSW 9 37,903,856 (GRCm39) missense probably damaging 1.00
R8286:Or8b35 UTSW 9 37,904,401 (GRCm39) nonsense probably null
X0064:Or8b35 UTSW 9 37,904,636 (GRCm39) missense probably benign 0.07
Posted On 2015-04-16