Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02282:Taar8b'

289873

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Taar8b

Ensembl Gene

ENSMUSG00000100186

Gene Name

trace amine-associated receptor 8B

Synonyms

LOC382348

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.146) question?

Stock #

IGL02282

Quality Score

Status

Chromosome

Chromosomal Location

23967158-23968192 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23967453 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Isoleucine at position 247 (K247I)

Ref Sequence

ENSEMBL: ENSMUSP00000090324 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092654]

AlphaFold

Q5QD06

Predicted Effect

possibly damaging
Transcript: ENSMUST00000092654
AA Change: K247I

PolyPhen 2 Score 0.834 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000090324
Gene: ENSMUSG00000100186
AA Change: K247I

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	39	244	1.4e-8	PFAM
Pfam:7TM_GPCR_Srsx	42	327	1.1e-14	PFAM
Pfam:7tm_1	48	312	6.4e-57	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	A	G	19: 8,983,351 (GRCm39)	D1545G	probably damaging	Het
Baiap3	A	C	17: 25,468,351 (GRCm39)	D234E	probably benign	Het
Bltp2	C	T	11: 78,175,054 (GRCm39)	P1730S	probably benign	Het
Cand1	T	A	10: 119,046,614 (GRCm39)	T959S	probably benign	Het
Ctdspl2	A	G	2: 121,807,959 (GRCm39)		probably benign	Het
Cyp2a4	A	C	7: 26,008,472 (GRCm39)	M205L	probably benign	Het
Dlx5	G	A	6: 6,881,762 (GRCm39)	A42V	probably damaging	Het
Dnah7a	A	G	1: 53,682,669 (GRCm39)	I267T	possibly damaging	Het
Dnajb6	A	G	5: 29,957,416 (GRCm39)	D66G	probably damaging	Het
Fgf8	T	C	19: 45,725,529 (GRCm39)	H201R	possibly damaging	Het
Gpc1	A	G	1: 92,785,689 (GRCm39)	K460E	probably damaging	Het
Gzme	A	T	14: 56,355,826 (GRCm39)	L162Q	probably damaging	Het
Ik	G	A	18: 36,878,697 (GRCm39)	G17D	probably damaging	Het
Il4	G	A	11: 53,509,001 (GRCm39)	T59M	probably damaging	Het
Kcnh3	G	T	15: 99,125,924 (GRCm39)		probably null	Het
Mill1	G	T	7: 17,997,129 (GRCm39)		probably null	Het
Npbwr1	A	T	1: 5,987,184 (GRCm39)	M110K	possibly damaging	Het
Opalin	A	T	19: 41,054,943 (GRCm39)	S84T	probably benign	Het
Or10w1	T	A	19: 13,632,622 (GRCm39)	D276E	probably damaging	Het
Or7g30	A	G	9: 19,352,914 (GRCm39)	Y235C	probably benign	Het
Or8b35	A	T	9: 37,904,318 (GRCm39)	I177F	probably damaging	Het
Pcdhb11	T	C	18: 37,556,881 (GRCm39)	L737P	probably damaging	Het
Phip	G	A	9: 82,795,743 (GRCm39)	S626L	probably benign	Het
Ppl	T	C	16: 4,919,322 (GRCm39)	D435G	probably damaging	Het
Prss37	A	G	6: 40,492,317 (GRCm39)	V178A	possibly damaging	Het
Ptpn7	A	G	1: 135,062,572 (GRCm39)	I104V	probably damaging	Het
Ptprn	A	G	1: 75,229,800 (GRCm39)	Y700H	probably damaging	Het
Rab11fip5	T	A	6: 85,314,534 (GRCm39)	T555S	probably damaging	Het
Rfwd3	A	T	8: 112,020,614 (GRCm39)		probably benign	Het
Robo1	G	A	16: 72,539,026 (GRCm39)	R41H	probably damaging	Het
Rps3	A	G	7: 99,128,479 (GRCm39)		probably null	Het
Ruvbl2	G	A	7: 45,074,589 (GRCm39)	T183I	probably benign	Het
Sema4c	A	T	1: 36,589,284 (GRCm39)		probably null	Het
Shoc1	A	C	4: 59,111,114 (GRCm39)	Y53D	unknown	Het
Tacr3	A	T	3: 134,566,834 (GRCm39)	I236F	probably benign	Het
Ttc21b	A	G	2: 66,022,081 (GRCm39)	I1168T	probably damaging	Het
Ttc9b	A	T	7: 27,355,336 (GRCm39)	D202V	probably damaging	Het
Vmn2r26	T	G	6: 124,038,584 (GRCm39)	C720G	probably damaging	Het
Vmn2r37	A	G	7: 9,209,761 (GRCm39)	S584P	probably benign	Het
Wnk2	T	A	13: 49,221,601 (GRCm39)	D1208V	probably damaging	Het
Zfp988	T	A	4: 147,416,125 (GRCm39)	C186*	probably null	Het
Zp3	A	G	5: 136,013,205 (GRCm39)	N179S	possibly damaging	Het

Other mutations in Taar8b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Taar8b	APN	10	23,967,654 (GRCm39)	missense	possibly damaging	0.69
IGL01380:Taar8b	APN	10	23,968,005 (GRCm39)	missense	probably damaging	1.00
IGL01536:Taar8b	APN	10	23,967,493 (GRCm39)	missense	probably benign
IGL02192:Taar8b	APN	10	23,967,262 (GRCm39)	missense	probably damaging	1.00
R0730:Taar8b	UTSW	10	23,967,924 (GRCm39)	missense	probably damaging	1.00
R1871:Taar8b	UTSW	10	23,967,900 (GRCm39)	missense	probably damaging	1.00
R2051:Taar8b	UTSW	10	23,967,212 (GRCm39)	missense	probably benign	0.38
R2265:Taar8b	UTSW	10	23,967,270 (GRCm39)	missense	probably damaging	0.99
R2267:Taar8b	UTSW	10	23,967,270 (GRCm39)	missense	probably damaging	0.99
R2268:Taar8b	UTSW	10	23,967,270 (GRCm39)	missense	probably damaging	0.99
R2269:Taar8b	UTSW	10	23,967,270 (GRCm39)	missense	probably damaging	0.99
R4598:Taar8b	UTSW	10	23,967,736 (GRCm39)	missense	probably benign
R4633:Taar8b	UTSW	10	23,968,150 (GRCm39)	nonsense	probably null
R4833:Taar8b	UTSW	10	23,968,030 (GRCm39)	missense	possibly damaging	0.77
R4949:Taar8b	UTSW	10	23,967,825 (GRCm39)	missense	probably damaging	1.00
R6104:Taar8b	UTSW	10	23,968,135 (GRCm39)	missense	probably damaging	1.00
R6178:Taar8b	UTSW	10	23,967,711 (GRCm39)	missense	probably benign	0.01
R6495:Taar8b	UTSW	10	23,967,160 (GRCm39)	makesense	probably null
R6816:Taar8b	UTSW	10	23,968,079 (GRCm39)	missense	probably benign	0.00
R6913:Taar8b	UTSW	10	23,967,963 (GRCm39)	missense	possibly damaging	0.95
R7072:Taar8b	UTSW	10	23,967,876 (GRCm39)	missense	possibly damaging	0.95
R7691:Taar8b	UTSW	10	23,967,436 (GRCm39)	nonsense	probably null
R8082:Taar8b	UTSW	10	23,967,789 (GRCm39)	missense	possibly damaging	0.93
R9023:Taar8b	UTSW	10	23,967,205 (GRCm39)	missense	probably benign

Posted On

2015-04-16