Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02282:Mill1'

289895

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mill1

Ensembl Gene

ENSMUSG00000054005

Gene Name

MHC I like leukocyte 1

Synonyms

5530400I18Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL02282

Quality Score

Status

Chromosome

Chromosomal Location

17979272-18000017 bp(+) (GRCm39)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

G to T at 17997129 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000069083 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000066780]

AlphaFold

Q8HWE7

Predicted Effect

probably null
Transcript: ENSMUST00000066780

SMART Domains

Protein: ENSMUSP00000069083
Gene: ENSMUSG00000054005

Domain	Start	End	E-Value	Type
signal peptide	1	32	N/A	INTRINSIC
Pfam:MHC_I	60	236	3.8e-33	PFAM
IGc1	255	327	3.53e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	A	G	19: 8,983,351 (GRCm39)	D1545G	probably damaging	Het
Baiap3	A	C	17: 25,468,351 (GRCm39)	D234E	probably benign	Het
Bltp2	C	T	11: 78,175,054 (GRCm39)	P1730S	probably benign	Het
Cand1	T	A	10: 119,046,614 (GRCm39)	T959S	probably benign	Het
Ctdspl2	A	G	2: 121,807,959 (GRCm39)		probably benign	Het
Cyp2a4	A	C	7: 26,008,472 (GRCm39)	M205L	probably benign	Het
Dlx5	G	A	6: 6,881,762 (GRCm39)	A42V	probably damaging	Het
Dnah7a	A	G	1: 53,682,669 (GRCm39)	I267T	possibly damaging	Het
Dnajb6	A	G	5: 29,957,416 (GRCm39)	D66G	probably damaging	Het
Fgf8	T	C	19: 45,725,529 (GRCm39)	H201R	possibly damaging	Het
Gpc1	A	G	1: 92,785,689 (GRCm39)	K460E	probably damaging	Het
Gzme	A	T	14: 56,355,826 (GRCm39)	L162Q	probably damaging	Het
Ik	G	A	18: 36,878,697 (GRCm39)	G17D	probably damaging	Het
Il4	G	A	11: 53,509,001 (GRCm39)	T59M	probably damaging	Het
Kcnh3	G	T	15: 99,125,924 (GRCm39)		probably null	Het
Npbwr1	A	T	1: 5,987,184 (GRCm39)	M110K	possibly damaging	Het
Opalin	A	T	19: 41,054,943 (GRCm39)	S84T	probably benign	Het
Or10w1	T	A	19: 13,632,622 (GRCm39)	D276E	probably damaging	Het
Or7g30	A	G	9: 19,352,914 (GRCm39)	Y235C	probably benign	Het
Or8b35	A	T	9: 37,904,318 (GRCm39)	I177F	probably damaging	Het
Pcdhb11	T	C	18: 37,556,881 (GRCm39)	L737P	probably damaging	Het
Phip	G	A	9: 82,795,743 (GRCm39)	S626L	probably benign	Het
Ppl	T	C	16: 4,919,322 (GRCm39)	D435G	probably damaging	Het
Prss37	A	G	6: 40,492,317 (GRCm39)	V178A	possibly damaging	Het
Ptpn7	A	G	1: 135,062,572 (GRCm39)	I104V	probably damaging	Het
Ptprn	A	G	1: 75,229,800 (GRCm39)	Y700H	probably damaging	Het
Rab11fip5	T	A	6: 85,314,534 (GRCm39)	T555S	probably damaging	Het
Rfwd3	A	T	8: 112,020,614 (GRCm39)		probably benign	Het
Robo1	G	A	16: 72,539,026 (GRCm39)	R41H	probably damaging	Het
Rps3	A	G	7: 99,128,479 (GRCm39)		probably null	Het
Ruvbl2	G	A	7: 45,074,589 (GRCm39)	T183I	probably benign	Het
Sema4c	A	T	1: 36,589,284 (GRCm39)		probably null	Het
Shoc1	A	C	4: 59,111,114 (GRCm39)	Y53D	unknown	Het
Taar8b	T	A	10: 23,967,453 (GRCm39)	K247I	possibly damaging	Het
Tacr3	A	T	3: 134,566,834 (GRCm39)	I236F	probably benign	Het
Ttc21b	A	G	2: 66,022,081 (GRCm39)	I1168T	probably damaging	Het
Ttc9b	A	T	7: 27,355,336 (GRCm39)	D202V	probably damaging	Het
Vmn2r26	T	G	6: 124,038,584 (GRCm39)	C720G	probably damaging	Het
Vmn2r37	A	G	7: 9,209,761 (GRCm39)	S584P	probably benign	Het
Wnk2	T	A	13: 49,221,601 (GRCm39)	D1208V	probably damaging	Het
Zfp988	T	A	4: 147,416,125 (GRCm39)	C186*	probably null	Het
Zp3	A	G	5: 136,013,205 (GRCm39)	N179S	possibly damaging	Het

Other mutations in Mill1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00514:Mill1	APN	7	17,998,566 (GRCm39)	missense	possibly damaging	0.91
IGL01313:Mill1	APN	7	17,998,558 (GRCm39)	missense	possibly damaging	0.82
IGL01417:Mill1	APN	7	17,998,708 (GRCm39)	missense	probably benign	0.18
IGL01997:Mill1	APN	7	17,989,814 (GRCm39)	missense	probably damaging	1.00
IGL03126:Mill1	APN	7	17,989,832 (GRCm39)	missense	probably benign	0.33
IGL03197:Mill1	APN	7	17,998,590 (GRCm39)	missense	probably benign	0.02
R0513:Mill1	UTSW	7	17,998,802 (GRCm39)	nonsense	probably null
R0515:Mill1	UTSW	7	17,998,798 (GRCm39)	missense	probably benign	0.12
R1460:Mill1	UTSW	7	17,996,595 (GRCm39)	missense	probably damaging	1.00
R1589:Mill1	UTSW	7	17,979,572 (GRCm39)	missense	probably benign	0.01
R2192:Mill1	UTSW	7	17,998,544 (GRCm39)	nonsense	probably null
R3704:Mill1	UTSW	7	17,996,978 (GRCm39)	missense	possibly damaging	0.91
R3758:Mill1	UTSW	7	17,996,628 (GRCm39)	critical splice donor site	probably null
R4685:Mill1	UTSW	7	17,989,853 (GRCm39)	missense	probably damaging	0.98
R4753:Mill1	UTSW	7	17,996,472 (GRCm39)	missense	probably benign	0.28
R5763:Mill1	UTSW	7	17,979,587 (GRCm39)	missense	probably benign	0.03
R5938:Mill1	UTSW	7	17,996,613 (GRCm39)	missense	probably benign	0.00
R7757:Mill1	UTSW	7	17,996,391 (GRCm39)	missense	probably benign	0.02
R8094:Mill1	UTSW	7	17,989,835 (GRCm39)	missense	probably benign	0.01
R8972:Mill1	UTSW	7	17,996,982 (GRCm39)	missense	probably benign	0.00
R9620:Mill1	UTSW	7	17,997,027 (GRCm39)	missense	probably benign	0.01
R9694:Mill1	UTSW	7	17,997,027 (GRCm39)	missense	probably benign	0.01
Z1176:Mill1	UTSW	7	17,979,424 (GRCm39)	start gained	probably benign

Posted On

2015-04-16