Incidental Mutation 'IGL02282:Ctdspl2'
ID289897
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ctdspl2
Ensembl Gene ENSMUSG00000033411
Gene NameCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
SynonymsD2Ertd485e
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.943) question?
Stock #IGL02282
Quality Score
Status
Chromosome2
Chromosomal Location121956001-122013642 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 121977478 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000106207 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036647] [ENSMUST00000110572] [ENSMUST00000110574] [ENSMUST00000110578]
Predicted Effect probably benign
Transcript: ENSMUST00000036647
SMART Domains Protein: ENSMUSP00000047543
Gene: ENSMUSG00000033411

DomainStartEndE-ValueType
CPDc 285 429 4.19e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110572
SMART Domains Protein: ENSMUSP00000106201
Gene: ENSMUSG00000033411

DomainStartEndE-ValueType
CPDc 214 358 4.19e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110574
SMART Domains Protein: ENSMUSP00000106203
Gene: ENSMUSG00000033411

DomainStartEndE-ValueType
CPDc 285 429 4.19e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110578
SMART Domains Protein: ENSMUSP00000106207
Gene: ENSMUSG00000033411

DomainStartEndE-ValueType
CPDc 284 428 4.19e-71 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127265
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128883
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131258
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138920
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140570
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610507B11Rik C T 11: 78,284,228 P1730S probably benign Het
Ahnak A G 19: 9,005,987 D1545G probably damaging Het
AI481877 A C 4: 59,111,114 Y53D unknown Het
Baiap3 A C 17: 25,249,377 D234E probably benign Het
Cand1 T A 10: 119,210,709 T959S probably benign Het
Cyp2a4 A C 7: 26,309,047 M205L probably benign Het
Dlx5 G A 6: 6,881,762 A42V probably damaging Het
Dnah7a A G 1: 53,643,510 I267T possibly damaging Het
Dnajb6 A G 5: 29,752,418 D66G probably damaging Het
Fgf8 T C 19: 45,737,090 H201R possibly damaging Het
Gpc1 A G 1: 92,857,967 K460E probably damaging Het
Gzme A T 14: 56,118,369 L162Q probably damaging Het
Ik G A 18: 36,745,644 G17D probably damaging Het
Il4 G A 11: 53,618,174 T59M probably damaging Het
Kcnh3 G T 15: 99,228,043 probably null Het
Mill1 G T 7: 18,263,204 probably null Het
Npbwr1 A T 1: 5,916,965 M110K possibly damaging Het
Olfr1490 T A 19: 13,655,258 D276E probably damaging Het
Olfr849 A G 9: 19,441,618 Y235C probably benign Het
Olfr881 A T 9: 37,993,022 I177F probably damaging Het
Opalin A T 19: 41,066,504 S84T probably benign Het
Pcdhb11 T C 18: 37,423,828 L737P probably damaging Het
Phip G A 9: 82,913,690 S626L probably benign Het
Ppl T C 16: 5,101,458 D435G probably damaging Het
Prss37 A G 6: 40,515,383 V178A possibly damaging Het
Ptpn7 A G 1: 135,134,834 I104V probably damaging Het
Ptprn A G 1: 75,253,156 Y700H probably damaging Het
Rab11fip5 T A 6: 85,337,552 T555S probably damaging Het
Rfwd3 A T 8: 111,293,982 probably benign Het
Robo1 G A 16: 72,742,138 R41H probably damaging Het
Rps3 A G 7: 99,479,272 probably null Het
Ruvbl2 G A 7: 45,425,165 T183I probably benign Het
Sema4c A T 1: 36,550,203 probably null Het
Taar8b T A 10: 24,091,555 K247I possibly damaging Het
Tacr3 A T 3: 134,861,073 I236F probably benign Het
Ttc21b A G 2: 66,191,737 I1168T probably damaging Het
Ttc9b A T 7: 27,655,911 D202V probably damaging Het
Vmn2r26 T G 6: 124,061,625 C720G probably damaging Het
Vmn2r37 A G 7: 9,206,762 S584P probably benign Het
Wnk2 T A 13: 49,068,125 D1208V probably damaging Het
Zfp988 T A 4: 147,331,668 C186* probably null Het
Zp3 A G 5: 135,984,351 N179S possibly damaging Het
Other mutations in Ctdspl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00984:Ctdspl2 APN 2 121969286 splice site probably benign
IGL02934:Ctdspl2 APN 2 121979009 missense probably damaging 1.00
IGL03100:Ctdspl2 APN 2 121978913 missense probably benign 0.27
IGL03285:Ctdspl2 APN 2 121986999 missense probably damaging 0.99
R0105:Ctdspl2 UTSW 2 121977320 splice site probably benign
R0521:Ctdspl2 UTSW 2 122006887 nonsense probably null
R1406:Ctdspl2 UTSW 2 122006868 missense probably damaging 1.00
R1406:Ctdspl2 UTSW 2 122006868 missense probably damaging 1.00
R1466:Ctdspl2 UTSW 2 122003929 missense probably benign 0.40
R1466:Ctdspl2 UTSW 2 122003929 missense probably benign 0.40
R1468:Ctdspl2 UTSW 2 121981281 missense probably benign
R1468:Ctdspl2 UTSW 2 121981281 missense probably benign
R1584:Ctdspl2 UTSW 2 122003929 missense probably benign 0.40
R2199:Ctdspl2 UTSW 2 121987029 critical splice donor site probably null
R2367:Ctdspl2 UTSW 2 121987018 missense probably benign 0.33
R4868:Ctdspl2 UTSW 2 121993398 missense possibly damaging 0.61
R5158:Ctdspl2 UTSW 2 121981293 missense probably benign 0.22
R5338:Ctdspl2 UTSW 2 121981312 missense probably benign 0.15
R5391:Ctdspl2 UTSW 2 122004148 critical splice donor site probably null
R5914:Ctdspl2 UTSW 2 121978933 missense probably damaging 1.00
R6009:Ctdspl2 UTSW 2 121988838 missense probably benign 0.01
R6196:Ctdspl2 UTSW 2 121978892 splice site probably null
R6676:Ctdspl2 UTSW 2 122006964 missense probably damaging 1.00
X0064:Ctdspl2 UTSW 2 122003947 missense probably damaging 1.00
Posted On2015-04-16