Incidental Mutation 'IGL02283:Gypa'
ID289924
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gypa
Ensembl Gene ENSMUSG00000051839
Gene Nameglycophorin A
SynonymsCD235a, GPA
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02283
Quality Score
Status
Chromosome8
Chromosomal Location80493781-80510542 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) G to A at 80494092 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000070836 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063359]
Predicted Effect probably benign
Transcript: ENSMUST00000063359
SMART Domains Protein: ENSMUSP00000070836
Gene: ENSMUSG00000051839

DomainStartEndE-ValueType
Pfam:Glycophorin_A 43 162 2.5e-53 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null mutation are viable and fertile; however, mutant erythrocytes had a reduced percentage of O-linked glycoproteins in the membranes, and were sensitive to hypoosmotic stress. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1l2 T C 10: 83,495,895 Y682C probably benign Het
Ank1 G A 8: 23,119,434 probably null Het
Arhgap1 A G 2: 91,670,776 N399S probably damaging Het
Atp8a2 A T 14: 60,016,799 I511N possibly damaging Het
Birc6 T A 17: 74,599,940 C1428S probably benign Het
Col18a1 T C 10: 77,113,109 T190A possibly damaging Het
Cpd A T 11: 76,840,425 D318E probably benign Het
Dync2h1 A T 9: 7,125,912 V1898E probably damaging Het
Gon4l T C 3: 88,895,364 M1095T probably damaging Het
Irf9 G A 14: 55,607,739 R352H probably damaging Het
Macf1 T C 4: 123,471,375 T1633A probably benign Het
Mars2 T C 1: 55,238,774 V512A probably damaging Het
Myo9a A G 9: 59,871,673 N1571D probably benign Het
Myrfl T C 10: 116,777,360 D846G probably benign Het
Olfr10 A G 11: 49,318,335 D263G probably benign Het
Olfr1423 A G 19: 12,035,855 S296P possibly damaging Het
Olfr319 A T 11: 58,702,276 T192S probably damaging Het
Olfr57 T C 10: 79,035,545 S250P probably damaging Het
Rprd2 A T 3: 95,765,503 S863T probably damaging Het
Sdf4 T A 4: 156,008,836 N208K probably benign Het
Sftpd A T 14: 41,172,466 V332D probably benign Het
Sh2b3 T C 5: 121,818,655 D321G probably benign Het
Slc45a2 T A 15: 11,001,182 N122K probably damaging Het
Slk T A 19: 47,641,993 F1170Y probably damaging Het
Spata7 A C 12: 98,658,258 T140P probably damaging Het
Vmn2r117 A G 17: 23,475,382 L497S probably damaging Het
Other mutations in Gypa
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00232:Gypa APN 8 80504779 splice site probably benign
R0067:Gypa UTSW 8 80503081 missense possibly damaging 0.71
R0094:Gypa UTSW 8 80500931 missense unknown
R0563:Gypa UTSW 8 80509460 missense probably benign 0.04
R0685:Gypa UTSW 8 80496702 splice site probably benign
R0729:Gypa UTSW 8 80496792 missense unknown
R0850:Gypa UTSW 8 80496345 missense unknown
R1299:Gypa UTSW 8 80496753 missense unknown
R2435:Gypa UTSW 8 80506768 splice site probably null
R4998:Gypa UTSW 8 80496335 missense unknown
R5121:Gypa UTSW 8 80496348 missense unknown
R6295:Gypa UTSW 8 80496340 missense unknown
R6827:Gypa UTSW 8 80504788 missense probably benign 0.00
Posted On2015-04-16